Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904793312> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2904793312 endingPage "162" @default.
- W2904793312 startingPage "153" @default.
- W2904793312 abstract "Classical signaling lymphocyte activating molecule (SLAM) family receptors are abundant within many types of immune cells, whereas the nonclassical SLAM family receptors SLAMF8 and SLAMF9, which uniquely lack cytoplasmic signaling motifs, are highly expressed by myeloid cells. Due to the potential redundancy, whether these two receptors regulate macrophage function remains largely unknown. Here, we show that SLAMF8 and SLAMF9 co-regulate macrophage-mediated liver inflammation. To overcome the redundancy, we generated mice that simultaneously lacked SLAMF8 and SLAMF9 using CRISPR-Cas9 technology. Although macrophage differentiation was not altered by the combined deficiency of SLAMF8 and SLAMF9, the loss of these two receptors significantly protected against lipopolysaccharide (LPS)-induced liver injury. SLAMF8 and SLAMF9 double-deficient mice had a prolonged survival rate and less infiltration of inflammatory cells. The depletion of macrophages using clodronate liposomes abolished the effects of SLAMF8 and SLAMF9 deficiencies on LPS-induced liver injury, which demonstrates that these receptors are required for macrophage activation following LPS challenge. Moreover, the deficiency of SLAMF8 and SLAMF9 suppressed the secretion of inflammatory cytokines by downregulating the expression of Toll-like receptor-4 (TLR4), a receptor that specifically binds LPS, which led to decreased mitogen-activated protein kinases (MAPK) signaling activation. Notably, combined injections of truncated extracellular SLAMF8 and SLAMF9 proteins significantly alleviated LPS-induced liver injury. Thus, our findings provide insights into the role of SLAMF8 and SLAMF9 in endotoxin-induced liver injury and suggest that SLAMF8 and SLAMF9 are potential therapeutic targets for acute hepatic injury." @default.
- W2904793312 created "2018-12-22" @default.
- W2904793312 creator A5015238969 @default.
- W2904793312 creator A5018342130 @default.
- W2904793312 creator A5034299294 @default.
- W2904793312 creator A5042178595 @default.
- W2904793312 creator A5046254335 @default.
- W2904793312 creator A5063927658 @default.
- W2904793312 creator A5069096075 @default.
- W2904793312 creator A5069304173 @default.
- W2904793312 creator A5070404677 @default.
- W2904793312 date "2018-12-14" @default.
- W2904793312 modified "2023-10-17" @default.
- W2904793312 title "Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages" @default.
- W2904793312 cites W1519600901 @default.
- W2904793312 cites W1535240987 @default.
- W2904793312 cites W1670964306 @default.
- W2904793312 cites W1918486464 @default.
- W2904793312 cites W1964951991 @default.
- W2904793312 cites W1989349686 @default.
- W2904793312 cites W2007265067 @default.
- W2904793312 cites W2017605206 @default.
- W2904793312 cites W2051820437 @default.
- W2904793312 cites W2071752467 @default.
- W2904793312 cites W2074834020 @default.
- W2904793312 cites W2079400568 @default.
- W2904793312 cites W2085128107 @default.
- W2904793312 cites W2092289140 @default.
- W2904793312 cites W2094981791 @default.
- W2904793312 cites W2106637648 @default.
- W2904793312 cites W2116621215 @default.
- W2904793312 cites W2122510983 @default.
- W2904793312 cites W2126811287 @default.
- W2904793312 cites W2146685446 @default.
- W2904793312 cites W2165089770 @default.
- W2904793312 cites W2279890691 @default.
- W2904793312 cites W2516293336 @default.
- W2904793312 cites W2566414030 @default.
- W2904793312 cites W2592709671 @default.
- W2904793312 cites W4211193493 @default.
- W2904793312 doi "https://doi.org/10.1038/s41423-018-0191-z" @default.
- W2904793312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7000402" @default.
- W2904793312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30552382" @default.
- W2904793312 hasPublicationYear "2018" @default.
- W2904793312 type Work @default.
- W2904793312 sameAs 2904793312 @default.
- W2904793312 citedByCount "31" @default.
- W2904793312 countsByYear W29047933122019 @default.
- W2904793312 countsByYear W29047933122020 @default.
- W2904793312 countsByYear W29047933122021 @default.
- W2904793312 countsByYear W29047933122022 @default.
- W2904793312 countsByYear W29047933122023 @default.
- W2904793312 crossrefType "journal-article" @default.
- W2904793312 hasAuthorship W2904793312A5015238969 @default.
- W2904793312 hasAuthorship W2904793312A5018342130 @default.
- W2904793312 hasAuthorship W2904793312A5034299294 @default.
- W2904793312 hasAuthorship W2904793312A5042178595 @default.
- W2904793312 hasAuthorship W2904793312A5046254335 @default.
- W2904793312 hasAuthorship W2904793312A5063927658 @default.
- W2904793312 hasAuthorship W2904793312A5069096075 @default.
- W2904793312 hasAuthorship W2904793312A5069304173 @default.
- W2904793312 hasAuthorship W2904793312A5070404677 @default.
- W2904793312 hasBestOaLocation W29047933121 @default.
- W2904793312 hasConcept C203014093 @default.
- W2904793312 hasConcept C2776070231 @default.
- W2904793312 hasConcept C2776914184 @default.
- W2904793312 hasConcept C71924100 @default.
- W2904793312 hasConceptScore W2904793312C203014093 @default.
- W2904793312 hasConceptScore W2904793312C2776070231 @default.
- W2904793312 hasConceptScore W2904793312C2776914184 @default.
- W2904793312 hasConceptScore W2904793312C71924100 @default.
- W2904793312 hasIssue "2" @default.
- W2904793312 hasLocation W29047933121 @default.
- W2904793312 hasLocation W29047933122 @default.
- W2904793312 hasLocation W29047933123 @default.
- W2904793312 hasOpenAccess W2904793312 @default.
- W2904793312 hasPrimaryLocation W29047933121 @default.
- W2904793312 hasRelatedWork W2127335531 @default.
- W2904793312 hasRelatedWork W2403031333 @default.
- W2904793312 hasRelatedWork W252748025 @default.
- W2904793312 hasRelatedWork W2735536323 @default.
- W2904793312 hasRelatedWork W2793969066 @default.
- W2904793312 hasRelatedWork W2799794258 @default.
- W2904793312 hasRelatedWork W2902744437 @default.
- W2904793312 hasRelatedWork W2972468021 @default.
- W2904793312 hasRelatedWork W3030583622 @default.
- W2904793312 hasRelatedWork W4285393563 @default.
- W2904793312 hasVolume "17" @default.
- W2904793312 isParatext "false" @default.
- W2904793312 isRetracted "false" @default.
- W2904793312 magId "2904793312" @default.
- W2904793312 workType "article" @default.