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- W2904802009 abstract "Metal-organic frameworks (MOFs) show promising application in biomedicine and pharmaceutics owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs are prepared from non-renewable or toxic materials, which limit their real-world applications. Cyclodextrins (CDs) are a typical natural and biodegradable cyclic oligosaccharide and are primarily used to enhance the aqueous solubility, safety, and bioavailability of drugs by virtue of its low toxicity and highly flexible structure, offering a peculiar ability to form CD/drug inclusions. A sophisticated strategy where CD is deployed as a ligand to form an assembly of cyclodextrin-based MOFs (CD-MOFs) may overcome real-world application drawbacks of MOFs. CD-MOFs incorporate the porous features of MOFs and the encapsulation capability of CD for drug molecules, leading to outstanding properties when compared with traditional hybrid materials. This review focuses on the inclusion technology and drug delivery properties associated with CD-MOFs. In addition, synthetic strategies and currently developed uses of CD-MOFs are highlighted as well. Also, perspectives and future challenges in this rapidly developing research area are discussed." @default.
- W2904802009 created "2018-12-22" @default.
- W2904802009 creator A5023728405 @default.
- W2904802009 creator A5028921036 @default.
- W2904802009 creator A5033796717 @default.
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- W2904802009 creator A5070780273 @default.
- W2904802009 creator A5080394702 @default.
- W2904802009 creator A5081022329 @default.
- W2904802009 date "2018-12-12" @default.
- W2904802009 modified "2023-10-05" @default.
- W2904802009 title "Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine" @default.
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