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• W2904808235 abstract "Abstract Persistent organic pollutants are a group of chemicals that include polychlorinated biphenyls (PCBs). PCBs exposure during adult life increases incidence and severity of cardiomyopathies, whereas in utero exposure determines congenital heart defects. Being fat-soluble, PCBs are passed to newborns through maternal milk, impairing heart functionality in the adult. It is still unknown how PCBs impair cardiac contraction at cellular/molecular levels. Here, we study the molecular mechanisms by which PCBs cause the observed heart contraction defects, analysing the alterations of Ca 2+ toolkit components that regulate contraction. We investigated the effect that Aroclor 1254 (Aroclor), a mixture of PCBs, has on perinatal-like cardiomyocytes derived from mouse embryonic stem cells. Cardiomyocytes, exposed to 1 or 2 µg/ml Aroclor for 24 h, were analyzed for their kinematics contractile properties and intracellular Ca 2+ dynamics. We observed that Aroclor impairs cardiomyocytes contractile properties by inhibiting spontaneous Ca 2+ oscillations. It disrupts intracellular Ca 2+ homeostasis by reducing the sarcoplasmic reticulum Ca 2+ content and by inhibiting voltage-gated Ca 2+ entry. These findings contribute to the understanding of the molecular underpinnings of PCBs-induced cardiovascular alterations, which are emerging as an additional life-threatening hurdle associated to PCBs pollution. Therefore, PCBs-dependent alteration of intracellular Ca 2+ dynamics is the most likely trigger of developmental cardiac functional alteration." @default.
• W2904808235 created "2018-12-22" @default.
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• W2904808235 date "2018-12-17" @default.
• W2904808235 modified "2023-10-16" @default.
• W2904808235 title "Polychlorinated biphenyls reduce the kinematics contractile properties of embryonic stem cells-derived cardiomyocytes by disrupting their intracellular Ca2+ dynamics" @default.
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• W2904808235 doi "https://doi.org/10.1038/s41598-018-36333-z" @default.
• W2904808235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6297156" @default.
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• W2904808235 hasPublicationYear "2018" @default.
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