FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904817619> ?p ?o ?g. }

• W2904817619 endingPage "295" @default.
• W2904817619 startingPage "290" @default.
• W2904817619 abstract "Background Dopaminergic activity within the dorsolateral prefrontal cortex (dlPFC) has been implicated in the control of cognitive flexibility. Much of the evidence for a causative relationship between cognitive flexibility and dopamine has come from animal studies, whilst human data have largely been correlational. Objective/Hypothesis:The current study examines whether changes in dopamine levels through tyrosine administration and suppression of dlPFC activity via cathodal tDCS could be causally related to cognitive flexibility as measured by task switching and reversal learning. Methods Using a crossover, double-blind, sham controlled, counterbalanced, randomized trial, we tested the effects of combining cathodal tDCS with tyrosine, a catecholaminergic precursor, with appropriate drug and tDCS placebo controls, on two measures of cognitive flexibility: probabilistic reversal learning, and task switching. Results While none of the manipulations had an effect on task switching, there was a significant main effect of cathodal tDCS and tyrosine on reversal learning. Reversal learning performance was significantly worsened by cathodal tDCS compared with sham tDCS, whilst tyrosine significantly improved performance compared with placebo. However, there was no significant tDCS × drugs interaction. Interestingly, and as predicted by our model, the combined administration of tyrosine with cathodal tDCS resulted in performance that was equivalent to the control condition (i.e. tDCS sham + placebo). Conclusions Our results suggest a causative role for dopamine signalling and dorsolateral prefrontal cortex activity in regulating indices of cognitive flexibility in humans." @default.
• W2904817619 created "2018-12-22" @default.
• W2904817619 creator A5017286649 @default.
• W2904817619 creator A5021877663 @default.
• W2904817619 creator A5044570092 @default.
• W2904817619 creator A5052071602 @default.
• W2904817619 creator A5057507525 @default.
• W2904817619 date "2019-03-01" @default.
• W2904817619 modified "2023-09-30" @default.
• W2904817619 title "Catecholaminergic modulation of indices of cognitive flexibility: A pharmaco-tDCS study" @default.
• W2904817619 cites W1783354124 @default.
• W2904817619 cites W1984430066 @default.
• W2904817619 cites W1987641088 @default.
• W2904817619 cites W1994267206 @default.
• W2904817619 cites W2010358276 @default.
• W2904817619 cites W2013952470 @default.
• W2904817619 cites W2034488360 @default.
• W2904817619 cites W2040234929 @default.
• W2904817619 cites W2048250663 @default.
• W2904817619 cites W2057538015 @default.
• W2904817619 cites W2059744198 @default.
• W2904817619 cites W2060636544 @default.
• W2904817619 cites W2064986030 @default.
• W2904817619 cites W2066692833 @default.
• W2904817619 cites W2068261202 @default.
• W2904817619 cites W2077726842 @default.
• W2904817619 cites W2079890482 @default.
• W2904817619 cites W2080398576 @default.
• W2904817619 cites W2086144447 @default.
• W2904817619 cites W2094076816 @default.
• W2904817619 cites W2097273459 @default.
• W2904817619 cites W2105007852 @default.
• W2904817619 cites W2109764946 @default.
• W2904817619 cites W2114022439 @default.
• W2904817619 cites W2114329358 @default.
• W2904817619 cites W2134551595 @default.
• W2904817619 cites W2138150447 @default.
• W2904817619 cites W2138608577 @default.
• W2904817619 cites W2148583163 @default.
• W2904817619 cites W2149681593 @default.
• W2904817619 cites W2154074499 @default.
• W2904817619 cites W2154517553 @default.
• W2904817619 cites W2161316082 @default.
• W2904817619 cites W2165364760 @default.
• W2904817619 cites W2170170290 @default.
• W2904817619 cites W2185428045 @default.
• W2904817619 cites W2274535154 @default.
• W2904817619 cites W2294342312 @default.
• W2904817619 cites W2304376073 @default.
• W2904817619 cites W2322488486 @default.
• W2904817619 cites W2339018270 @default.
• W2904817619 cites W2368808589 @default.
• W2904817619 cites W2396134680 @default.
• W2904817619 cites W2473634812 @default.
• W2904817619 cites W2555932794 @default.
• W2904817619 cites W2557431955 @default.
• W2904817619 cites W2584048471 @default.
• W2904817619 cites W2590828580 @default.
• W2904817619 cites W2591615181 @default.
• W2904817619 cites W2613241826 @default.
• W2904817619 cites W2762014648 @default.
• W2904817619 cites W2764218690 @default.
• W2904817619 cites W2769021531 @default.
• W2904817619 cites W2952324088 @default.
• W2904817619 doi "https://doi.org/10.1016/j.brs.2018.12.001" @default.
• W2904817619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7116420" @default.
• W2904817619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30552060" @default.
• W2904817619 hasPublicationYear "2019" @default.
• W2904817619 type Work @default.
• W2904817619 sameAs 2904817619 @default.
• W2904817619 citedByCount "14" @default.
• W2904817619 countsByYear W29048176192019 @default.
• W2904817619 countsByYear W29048176192020 @default.
• W2904817619 countsByYear W29048176192021 @default.
• W2904817619 countsByYear W29048176192022 @default.
• W2904817619 countsByYear W29048176192023 @default.
• W2904817619 crossrefType "journal-article" @default.
• W2904817619 hasAuthorship W2904817619A5017286649 @default.
• W2904817619 hasAuthorship W2904817619A5021877663 @default.
• W2904817619 hasAuthorship W2904817619A5044570092 @default.
• W2904817619 hasAuthorship W2904817619A5052071602 @default.
• W2904817619 hasAuthorship W2904817619A5057507525 @default.
• W2904817619 hasBestOaLocation W29048176192 @default.
• W2904817619 hasConcept C137183658 @default.
• W2904817619 hasConcept C15744967 @default.
• W2904817619 hasConcept C169760540 @default.
• W2904817619 hasConcept C169900460 @default.
• W2904817619 hasConcept C185711340 @default.
• W2904817619 hasConcept C24998067 @default.
• W2904817619 hasConcept C2776824294 @default.
• W2904817619 hasConcept C2777803708 @default.
• W2904817619 hasConcept C2780508717 @default.
• W2904817619 hasConcept C2781195155 @default.
• W2904817619 hasConcept C513476851 @default.
• W2904817619 hasConcept C66102695 @default.
• W2904817619 hasConceptScore W2904817619C137183658 @default.
• W2904817619 hasConceptScore W2904817619C15744967 @default.
• W2904817619 hasConceptScore W2904817619C169760540 @default.

• next