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- W2904830650 abstract "A key aim of using a metabolomics approach is to obtain (ultimately) an answer to a well-defined biological question. To this end, state-of-the-art analytical separation techniques are currently used for the reliable profiling of (endogenous) metabolites in a wide range of biological samples. Within metabolomics, capillary electrophoresis–mass spectrometry (CE-MS) has become a very strong analytical tool for the selective profiling of polar and charged metabolites. In CE, compounds are separated according to their charge-to-size ratio and, therefore, the separation mechanism of this approach is fundamentally different from chromatographic-based separation techniques. As such, CE-MS provides complementary information on the metabolic composition of biological samples. In this chapter, the utility of CE and CE-MS for the analysis of (highly) polar and charged metabolites is described from a historical perspective. Attention is devoted to some research works from a few decades ago in which the value of CE for the selective analysis of a few (endogenous) metabolites in human body fluids was demonstrated. Then, seminal research works on the development of CE-MS methods for targeted and non-targeted metabolomics studies are discussed. Finally, the current situation of CE-MS in metabolomics is considered and a view on where this approach may head to is provided." @default.
- W2904830650 created "2018-12-22" @default.
- W2904830650 creator A5026406611 @default.
- W2904830650 date "2018-07-13" @default.
- W2904830650 modified "2023-09-24" @default.
- W2904830650 title "Capillary Electrophoresis–Mass Spectrometry for Metabolomics – From Metabolite Analysis to Metabolic Profiling" @default.
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- W2904830650 doi "https://doi.org/10.1039/9781788012737-00001" @default.
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