FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904853275> ?p ?o ?g. }

• W2904853275 endingPage "2012" @default.
• W2904853275 startingPage "2005" @default.
• W2904853275 abstract "Monoclonal antibodies have emerged as an important class of therapeutics in oncological and autoimmune diseases due to their several attractive properties, such as high binding affinity and specificity. However, it has recently become clear that antibodies recovered from serum show a significantly decreased potency owing to various reasons, including deamidation, oxidation, fragment antigen binding (Fab) exchange, and disulfide shuffling. Fab exchange and disulfide shuffling result because of the instability of disulfides in serum. Herein, we reported a 'one-pot' stapling strategy using isobutylene motifs to stabilise the interchain disulfides of antibodies. This general method was applied to a Fab fragment of the anti-HER2 antibody. The stapled Fab was completely stable in the presence of biological thiols. The approach was further applied to two different full-length IgGs, trastuzumab and rituximab, under mild and biocompatible conditions. The binding affinity of the antibody was enhanced, relative to its native form, after being stapled. The stapled structure maintained its effector functions and behaved similarly to its native form in vivo. This work provides a straightforward and scalable method for the stabilisation of antibodies in various formats." @default.
• W2904853275 created "2018-12-22" @default.
• W2904853275 creator A5036452943 @default.
• W2904853275 creator A5042517924 @default.
• W2904853275 creator A5043826156 @default.
• W2904853275 creator A5050238909 @default.
• W2904853275 creator A5055783265 @default.
• W2904853275 creator A5064048730 @default.
• W2904853275 creator A5074420777 @default.
• W2904853275 creator A5084372114 @default.
• W2904853275 date "2019-01-01" @default.
• W2904853275 modified "2023-10-18" @default.
• W2904853275 title "One-pot stapling of interchain disulfides of antibodies using an isobutylene motif" @default.
• W2904853275 cites W1487052430 @default.
• W2904853275 cites W1555361166 @default.
• W2904853275 cites W1907580482 @default.
• W2904853275 cites W1967693680 @default.
• W2904853275 cites W1979780600 @default.
• W2904853275 cites W1980594873 @default.
• W2904853275 cites W1998210183 @default.
• W2904853275 cites W2000106654 @default.
• W2904853275 cites W2004290717 @default.
• W2904853275 cites W2038319340 @default.
• W2904853275 cites W2042712910 @default.
• W2904853275 cites W2050754173 @default.
• W2904853275 cites W2051995022 @default.
• W2904853275 cites W2062013025 @default.
• W2904853275 cites W2087638630 @default.
• W2904853275 cites W2110969535 @default.
• W2904853275 cites W2117131474 @default.
• W2904853275 cites W2120920314 @default.
• W2904853275 cites W2167569919 @default.
• W2904853275 cites W2169656611 @default.
• W2904853275 cites W2272264121 @default.
• W2904853275 cites W2326306194 @default.
• W2904853275 cites W2537629632 @default.
• W2904853275 cites W2753415165 @default.
• W2904853275 cites W2762743006 @default.
• W2904853275 cites W2766458409 @default.
• W2904853275 cites W2766664946 @default.
• W2904853275 cites W2805822355 @default.
• W2904853275 doi "https://doi.org/10.1039/c8ob02877j" @default.
• W2904853275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30539956" @default.
• W2904853275 hasPublicationYear "2019" @default.
• W2904853275 type Work @default.
• W2904853275 sameAs 2904853275 @default.
• W2904853275 citedByCount "15" @default.
• W2904853275 countsByYear W29048532752019 @default.
• W2904853275 countsByYear W29048532752020 @default.
• W2904853275 countsByYear W29048532752021 @default.
• W2904853275 countsByYear W29048532752022 @default.
• W2904853275 countsByYear W29048532752023 @default.
• W2904853275 crossrefType "journal-article" @default.
• W2904853275 hasAuthorship W2904853275A5036452943 @default.
• W2904853275 hasAuthorship W2904853275A5042517924 @default.
• W2904853275 hasAuthorship W2904853275A5043826156 @default.
• W2904853275 hasAuthorship W2904853275A5050238909 @default.
• W2904853275 hasAuthorship W2904853275A5055783265 @default.
• W2904853275 hasAuthorship W2904853275A5064048730 @default.
• W2904853275 hasAuthorship W2904853275A5074420777 @default.
• W2904853275 hasAuthorship W2904853275A5084372114 @default.
• W2904853275 hasBestOaLocation W29048532752 @default.
• W2904853275 hasConcept C104317684 @default.
• W2904853275 hasConcept C111919701 @default.
• W2904853275 hasConcept C159654299 @default.
• W2904853275 hasConcept C167625842 @default.
• W2904853275 hasConcept C181199279 @default.
• W2904853275 hasConcept C185592680 @default.
• W2904853275 hasConcept C203014093 @default.
• W2904853275 hasConcept C21951064 @default.
• W2904853275 hasConcept C27256138 @default.
• W2904853275 hasConcept C2780557392 @default.
• W2904853275 hasConcept C2780784506 @default.
• W2904853275 hasConcept C2909223937 @default.
• W2904853275 hasConcept C41008148 @default.
• W2904853275 hasConcept C542903549 @default.
• W2904853275 hasConcept C55493867 @default.
• W2904853275 hasConcept C71240020 @default.
• W2904853275 hasConcept C85630698 @default.
• W2904853275 hasConcept C86803240 @default.
• W2904853275 hasConceptScore W2904853275C104317684 @default.
• W2904853275 hasConceptScore W2904853275C111919701 @default.
• W2904853275 hasConceptScore W2904853275C159654299 @default.
• W2904853275 hasConceptScore W2904853275C167625842 @default.
• W2904853275 hasConceptScore W2904853275C181199279 @default.
• W2904853275 hasConceptScore W2904853275C185592680 @default.
• W2904853275 hasConceptScore W2904853275C203014093 @default.
• W2904853275 hasConceptScore W2904853275C21951064 @default.
• W2904853275 hasConceptScore W2904853275C27256138 @default.
• W2904853275 hasConceptScore W2904853275C2780557392 @default.
• W2904853275 hasConceptScore W2904853275C2780784506 @default.
• W2904853275 hasConceptScore W2904853275C2909223937 @default.
• W2904853275 hasConceptScore W2904853275C41008148 @default.
• W2904853275 hasConceptScore W2904853275C542903549 @default.
• W2904853275 hasConceptScore W2904853275C55493867 @default.
• W2904853275 hasConceptScore W2904853275C71240020 @default.
• W2904853275 hasConceptScore W2904853275C85630698 @default.
• W2904853275 hasConceptScore W2904853275C86803240 @default.

• next