FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904862932> ?p ?o ?g. }

• W2904862932 abstract "Cellular senescence is a state of irreversible cell growth arrest and senescence cells permanently lose proliferation potential. Induction of cellular senescence might be a novel therapy for cancer cells. TRIB2 has been reported to participate in regulating proliferation and drug resistance of various cancer cells. However, the role of TRIB2 in cellular senescence of colorectal cancer (CRC) and its molecular mechanism remains unclear.The expression of TRIB2 in colorectal cancer tissues and adjacent tissues was detected by immunohistochemistry and RT-PCR. The growth, cell cycle distribution and cellular senescence of colorectal cancer cells were evaluated by Cell Counting Kit-8 (CCK8) assay, flow cytometry detection and senescence-associated β-galactosidase staining, respectively. Western blot, RT-PCR and luciferase assay were performed to determine how TRIB2 regulates p21. Immunoprecipitation (IP) and chromatin-immunoprecipitation (ChIP) were used to investigate the molecular mechanisms.We found that TRIB2 expression was elevated in CRC tissues compared to normal adjacent tissues and high TRIB2 expression indicated poor prognosis of CRC patients. Functionally, depletion of TRIB2 inhibited cancer cells proliferation, induced cell cycle arrest and promoted cellular senescence, whereas overexpression of TRIB2 accelerated cell growth, cell cycle progression and blocked cellular senescence. Further studies showed that TRIB2 physically interacted with AP4 and inhibited p21 expression through enhancing transcription activities of AP4. The rescue experiments indicated that silencing of AP4 abrogated the inhibition of cellular senescence induced by TRIB2 overexpression.These data demonstrate that TRIB2 suppresses cellular senescence through interaction with AP4 to down-regulate p21 expression. Therefore, TRIB2 could be a potential target for CRC treatment." @default.
• W2904862932 created "2018-12-22" @default.
• W2904862932 creator A5003113410 @default.
• W2904862932 creator A5020497057 @default.
• W2904862932 creator A5039925585 @default.
• W2904862932 creator A5040789255 @default.
• W2904862932 creator A5058315960 @default.
• W2904862932 creator A5066908261 @default.
• W2904862932 creator A5070170359 @default.
• W2904862932 creator A5074907566 @default.
• W2904862932 creator A5075068220 @default.
• W2904862932 date "2018-12-01" @default.
• W2904862932 modified "2023-10-15" @default.
• W2904862932 title "TRIB2 functions as novel oncogene in colorectal cancer by blocking cellular senescence through AP4/p21 signaling" @default.
• W2904862932 cites W1974351849 @default.
• W2904862932 cites W1980878904 @default.
• W2904862932 cites W1987480626 @default.
• W2904862932 cites W1991402389 @default.
• W2904862932 cites W1991642946 @default.
• W2904862932 cites W1997032085 @default.
• W2904862932 cites W2000179223 @default.
• W2904862932 cites W2007857578 @default.
• W2904862932 cites W2034488184 @default.
• W2904862932 cites W2054519549 @default.
• W2904862932 cites W2054666013 @default.
• W2904862932 cites W2057654378 @default.
• W2904862932 cites W2058390366 @default.
• W2904862932 cites W2061917886 @default.
• W2904862932 cites W2075152619 @default.
• W2904862932 cites W2079449199 @default.
• W2904862932 cites W2087913996 @default.
• W2904862932 cites W2088990880 @default.
• W2904862932 cites W2090067193 @default.
• W2904862932 cites W2090928161 @default.
• W2904862932 cites W2092664001 @default.
• W2904862932 cites W2094920355 @default.
• W2904862932 cites W2107800068 @default.
• W2904862932 cites W2111450457 @default.
• W2904862932 cites W2115614036 @default.
• W2904862932 cites W2116437342 @default.
• W2904862932 cites W2134847924 @default.
• W2904862932 cites W2136729555 @default.
• W2904862932 cites W2143747809 @default.
• W2904862932 cites W2144566858 @default.
• W2904862932 cites W2147242002 @default.
• W2904862932 cites W2150748567 @default.
• W2904862932 cites W2162262059 @default.
• W2904862932 cites W2180320091 @default.
• W2904862932 cites W2270670667 @default.
• W2904862932 cites W2333101883 @default.
• W2904862932 cites W2346269401 @default.
• W2904862932 cites W2518841168 @default.
• W2904862932 cites W2559634823 @default.
• W2904862932 cites W2594883857 @default.
• W2904862932 cites W2612676865 @default.
• W2904862932 cites W2724654878 @default.
• W2904862932 cites W2769025282 @default.
• W2904862932 cites W2802615563 @default.
• W2904862932 cites W4210433744 @default.
• W2904862932 doi "https://doi.org/10.1186/s12943-018-0922-x" @default.
• W2904862932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6291992" @default.
• W2904862932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30541550" @default.
• W2904862932 hasPublicationYear "2018" @default.
• W2904862932 type Work @default.
• W2904862932 sameAs 2904862932 @default.
• W2904862932 citedByCount "55" @default.
• W2904862932 countsByYear W29048629322019 @default.
• W2904862932 countsByYear W29048629322020 @default.
• W2904862932 countsByYear W29048629322021 @default.
• W2904862932 countsByYear W29048629322022 @default.
• W2904862932 countsByYear W29048629322023 @default.
• W2904862932 crossrefType "journal-article" @default.
• W2904862932 hasAuthorship W2904862932A5003113410 @default.
• W2904862932 hasAuthorship W2904862932A5020497057 @default.
• W2904862932 hasAuthorship W2904862932A5039925585 @default.
• W2904862932 hasAuthorship W2904862932A5040789255 @default.
• W2904862932 hasAuthorship W2904862932A5058315960 @default.
• W2904862932 hasAuthorship W2904862932A5066908261 @default.
• W2904862932 hasAuthorship W2904862932A5070170359 @default.
• W2904862932 hasAuthorship W2904862932A5074907566 @default.
• W2904862932 hasAuthorship W2904862932A5075068220 @default.
• W2904862932 hasBestOaLocation W29048629321 @default.
• W2904862932 hasConcept C101762097 @default.
• W2904862932 hasConcept C104317684 @default.
• W2904862932 hasConcept C119056186 @default.
• W2904862932 hasConcept C134320426 @default.
• W2904862932 hasConcept C1491633281 @default.
• W2904862932 hasConcept C150194340 @default.
• W2904862932 hasConcept C153911025 @default.
• W2904862932 hasConcept C29537977 @default.
• W2904862932 hasConcept C502942594 @default.
• W2904862932 hasConcept C522857546 @default.
• W2904862932 hasConcept C54355233 @default.
• W2904862932 hasConcept C553184892 @default.
• W2904862932 hasConcept C62112901 @default.
• W2904862932 hasConcept C81885089 @default.
• W2904862932 hasConcept C86803240 @default.
• W2904862932 hasConcept C95444343 @default.
• W2904862932 hasConceptScore W2904862932C101762097 @default.
• W2904862932 hasConceptScore W2904862932C104317684 @default.

• next