FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904862960> ?p ?o ?g. }

• W2904862960 endingPage "920" @default.
• W2904862960 startingPage "903" @default.
• W2904862960 abstract "NMDA receptors (NMDARs) are required for long-term depression (LTD) at parallel fibre-Purkinje cell synapses, but their cellular localization and physiological functions in vivo are unclear. NMDARs in molecular-layer interneurons (MLIs), but not granule cells or Purkinje cells, are required for LTD, but not long-term potentiation induced by low-frequency stimulation of parallel fibres. Nitric oxide produced by NMDAR activation in MLIs probably mediates LTD induction. NMDARs in granule cells or Purkinje cells are dispensable for motor learning during adaptation of horizontal optokinetic responses.Long-term potentiation (LTP) and depression (LTD), which serve as cellular synaptic plasticity models for learning and memory, are crucially regulated by N-methyl-d-aspartate receptors (NMDARs) in various brain regions. In the cerebellum, LTP and LTD at parallel fibre (PF)-Purkinje cell (PC) synapses are thought to mediate certain forms of motor learning. However, while NMDARs are essential for LTD in vitro, their cellular localization remains controversial. In addition, whether and how NMDARs mediate motor learning in vivo remains unclear. Here, we examined the contribution of NMDARs expressed in granule cells (GCs), PCs and molecular-layer interneurons (MLIs) to LTD/LTP and motor learning by generating GC-, PC- and MLI/PC-specific knockouts of Grin1, a gene encoding an obligatory GluN1 subunit of NMDARs. While robust LTD and LTP were induced at PF-PC synapses in GC- and PC-specific Grin1 (GC-Grin1 and PC-Grin1, respectively) conditional knockout (cKO) mice, only LTD was impaired in MLI/PC-specific Grin1 (MLI/PC-Grin1) cKO mice. Application of diethylamine nitric oxide (NO) sodium, a potent NO donor, to the cerebellar slices restored LTD in MLI/PC-Grin1 cKO mice, suggesting that NO is probably downstream to NMDARs. Furthermore, the adaptation of horizontal optokinetic responses (hOKR), a cerebellar motor learning task, was normally observed in GC-Grin1 cKO and PC-Grin1 cKO mice, but not in MLI/PC-Grin1 cKO mice. These results indicate that it is the NMDARs expressed in MLIs, but not in PCs or GCs, that play important roles in LTD in vitro and motor learning in vivo." @default.
• W2904862960 created "2018-12-22" @default.
• W2904862960 creator A5015389182 @default.
• W2904862960 creator A5017102129 @default.
• W2904862960 creator A5069509461 @default.
• W2904862960 creator A5077366980 @default.
• W2904862960 date "2018-11-24" @default.
• W2904862960 modified "2023-10-14" @default.
• W2904862960 title "Interneuronal NMDA receptors regulate long‐term depression and motor learning in the cerebellum" @default.
• W2904862960 cites W1545709084 @default.
• W2904862960 cites W1553334375 @default.
• W2904862960 cites W1863375292 @default.
• W2904862960 cites W1926351161 @default.
• W2904862960 cites W1943801961 @default.
• W2904862960 cites W1966322594 @default.
• W2904862960 cites W1968072827 @default.
• W2904862960 cites W1972727610 @default.
• W2904862960 cites W1981032249 @default.
• W2904862960 cites W1992780981 @default.
• W2904862960 cites W1995892478 @default.
• W2904862960 cites W1996445996 @default.
• W2904862960 cites W1999531329 @default.
• W2904862960 cites W2000502075 @default.
• W2904862960 cites W2003761697 @default.
• W2904862960 cites W2010778459 @default.
• W2904862960 cites W2018879423 @default.
• W2904862960 cites W2019297438 @default.
• W2904862960 cites W2023465483 @default.
• W2904862960 cites W2024312922 @default.
• W2904862960 cites W2024380057 @default.
• W2904862960 cites W2024862570 @default.
• W2904862960 cites W2027196516 @default.
• W2904862960 cites W2029565790 @default.
• W2904862960 cites W2039092258 @default.
• W2904862960 cites W2040367183 @default.
• W2904862960 cites W2051909860 @default.
• W2904862960 cites W2052729994 @default.
• W2904862960 cites W2057461097 @default.
• W2904862960 cites W2058296570 @default.
• W2904862960 cites W2067484466 @default.
• W2904862960 cites W2069979321 @default.
• W2904862960 cites W2073596111 @default.
• W2904862960 cites W2074766640 @default.
• W2904862960 cites W2076236349 @default.
• W2904862960 cites W2081322688 @default.
• W2904862960 cites W2081549844 @default.
• W2904862960 cites W2084606607 @default.
• W2904862960 cites W2100633666 @default.
• W2904862960 cites W2101477554 @default.
• W2904862960 cites W2110146301 @default.
• W2904862960 cites W2117006280 @default.
• W2904862960 cites W2121242757 @default.
• W2904862960 cites W2132915433 @default.
• W2904862960 cites W2135164856 @default.
• W2904862960 cites W2140439285 @default.
• W2904862960 cites W2157702984 @default.
• W2904862960 cites W2157867129 @default.
• W2904862960 cites W2166491434 @default.
• W2904862960 cites W2166991426 @default.
• W2904862960 cites W2167279371 @default.
• W2904862960 cites W2218016673 @default.
• W2904862960 cites W2273328215 @default.
• W2904862960 cites W2307304937 @default.
• W2904862960 cites W2320983896 @default.
• W2904862960 cites W2341498450 @default.
• W2904862960 cites W2516656566 @default.
• W2904862960 cites W2578571546 @default.
• W2904862960 cites W2731873846 @default.
• W2904862960 doi "https://doi.org/10.1113/jp276794" @default.
• W2904862960 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6355717" @default.
• W2904862960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30382582" @default.
• W2904862960 hasPublicationYear "2018" @default.
• W2904862960 type Work @default.
• W2904862960 sameAs 2904862960 @default.
• W2904862960 citedByCount "26" @default.
• W2904862960 countsByYear W29048629602018 @default.
• W2904862960 countsByYear W29048629602019 @default.
• W2904862960 countsByYear W29048629602020 @default.
• W2904862960 countsByYear W29048629602021 @default.
• W2904862960 countsByYear W29048629602022 @default.
• W2904862960 countsByYear W29048629602023 @default.
• W2904862960 crossrefType "journal-article" @default.
• W2904862960 hasAuthorship W2904862960A5015389182 @default.
• W2904862960 hasAuthorship W2904862960A5017102129 @default.
• W2904862960 hasAuthorship W2904862960A5069509461 @default.
• W2904862960 hasAuthorship W2904862960A5077366980 @default.
• W2904862960 hasBestOaLocation W29048629601 @default.
• W2904862960 hasConcept C107690735 @default.
• W2904862960 hasConcept C160268369 @default.
• W2904862960 hasConcept C169760540 @default.
• W2904862960 hasConcept C170493617 @default.
• W2904862960 hasConcept C185592680 @default.
• W2904862960 hasConcept C25274449 @default.
• W2904862960 hasConcept C2776464000 @default.
• W2904862960 hasConcept C2778888523 @default.
• W2904862960 hasConcept C2779652256 @default.
• W2904862960 hasConcept C2781161787 @default.
• W2904862960 hasConcept C55493867 @default.

• next