Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904863982> ?p ?o ?g. }
- W2904863982 abstract "Diabetic kidney disease (DKD) is a heritable but poorly understood complication of diabetes. To identify genetic variants predisposing to DKD, we performed genome-wide association analyses in 19,406 individuals with type 1 diabetes (T1D) using a spectrum of DKD definitions basedon albuminuria and renal function. We identified 16 genome-wide significant loci. The variant with the strongest association (rs55703767) is a common missense mutation in the collagen type IV alpha 3 chain (COL4A3) gene, which encodes a major structural component of the glomerular basement membrane (GBM) implicated in heritable nephropathies. The rs55703767 minor allele (Asp326Tyr) is protective against several definitions of DKD, including albuminuria and end-stage renal disease. Three other loci are in or near genes with known or suggestive involvement in DKD (BMP7) or renal biology ( COLEC11 and DDR1 ). The 16 DKD-associated loci provide novel insights into the pathogenesis of DKD, identifying potential biological targets for prevention and treatment." @default.
- W2904863982 created "2018-12-22" @default.
- W2904863982 creator A5000783448 @default.
- W2904863982 creator A5001552586 @default.
- W2904863982 creator A5001657809 @default.
- W2904863982 creator A5005414020 @default.
- W2904863982 creator A5007221570 @default.
- W2904863982 creator A5009751579 @default.
- W2904863982 creator A5009996821 @default.
- W2904863982 creator A5012676820 @default.
- W2904863982 creator A5014495474 @default.
- W2904863982 creator A5016205185 @default.
- W2904863982 creator A5018962385 @default.
- W2904863982 creator A5019753994 @default.
- W2904863982 creator A5020281503 @default.
- W2904863982 creator A5020957849 @default.
- W2904863982 creator A5022907613 @default.
- W2904863982 creator A5023546213 @default.
- W2904863982 creator A5024539691 @default.
- W2904863982 creator A5025058942 @default.
- W2904863982 creator A5025610737 @default.
- W2904863982 creator A5026764667 @default.
- W2904863982 creator A5027108736 @default.
- W2904863982 creator A5028871333 @default.
- W2904863982 creator A5029308681 @default.
- W2904863982 creator A5030746476 @default.
- W2904863982 creator A5031995680 @default.
- W2904863982 creator A5032771884 @default.
- W2904863982 creator A5032870005 @default.
- W2904863982 creator A5033725683 @default.
- W2904863982 creator A5036151193 @default.
- W2904863982 creator A5036440403 @default.
- W2904863982 creator A5036821582 @default.
- W2904863982 creator A5037199781 @default.
- W2904863982 creator A5037219182 @default.
- W2904863982 creator A5038318320 @default.
- W2904863982 creator A5038456538 @default.
- W2904863982 creator A5038567891 @default.
- W2904863982 creator A5039339457 @default.
- W2904863982 creator A5039750697 @default.
- W2904863982 creator A5044484087 @default.
- W2904863982 creator A5045772838 @default.
- W2904863982 creator A5047478353 @default.
- W2904863982 creator A5052936935 @default.
- W2904863982 creator A5053364246 @default.
- W2904863982 creator A5053959156 @default.
- W2904863982 creator A5054146938 @default.
- W2904863982 creator A5054663921 @default.
- W2904863982 creator A5054730127 @default.
- W2904863982 creator A5054848879 @default.
- W2904863982 creator A5055801734 @default.
- W2904863982 creator A5057297665 @default.
- W2904863982 creator A5058474990 @default.
- W2904863982 creator A5059070322 @default.
- W2904863982 creator A5061001113 @default.
- W2904863982 creator A5061155960 @default.
- W2904863982 creator A5061631272 @default.
- W2904863982 creator A5061952775 @default.
- W2904863982 creator A5062347941 @default.
- W2904863982 creator A5063091317 @default.
- W2904863982 creator A5063093429 @default.
- W2904863982 creator A5064948585 @default.
- W2904863982 creator A5065966856 @default.
- W2904863982 creator A5066073550 @default.
- W2904863982 creator A5067092840 @default.
- W2904863982 creator A5069071162 @default.
- W2904863982 creator A5070735232 @default.
- W2904863982 creator A5070950600 @default.
- W2904863982 creator A5072484853 @default.
- W2904863982 creator A5073141203 @default.
- W2904863982 creator A5074266062 @default.
- W2904863982 creator A5074771810 @default.
- W2904863982 creator A5075863437 @default.
- W2904863982 creator A5076618443 @default.
- W2904863982 creator A5077228809 @default.
- W2904863982 creator A5077291181 @default.
- W2904863982 creator A5078291934 @default.
- W2904863982 creator A5078425221 @default.
- W2904863982 creator A5078691217 @default.
- W2904863982 creator A5078759816 @default.
- W2904863982 creator A5082643599 @default.
- W2904863982 creator A5086527990 @default.
- W2904863982 creator A5086996253 @default.
- W2904863982 creator A5088350286 @default.
- W2904863982 creator A5088500025 @default.
- W2904863982 creator A5088560891 @default.
- W2904863982 creator A5089786480 @default.
- W2904863982 creator A5090249258 @default.
- W2904863982 creator A5090729869 @default.
- W2904863982 creator A5091075100 @default.
- W2904863982 date "2018-12-19" @default.
- W2904863982 modified "2023-09-29" @default.
- W2904863982 title "Genome-wide association study of diabetic kidney disease highlights biology involved in renal basement membrane collagen" @default.
- W2904863982 cites W1492754188 @default.
- W2904863982 cites W1552051186 @default.
- W2904863982 cites W1568637272 @default.
- W2904863982 cites W1605145036 @default.
- W2904863982 cites W1866000643 @default.
- W2904863982 cites W1973646620 @default.
- W2904863982 cites W1980453073 @default.