FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904871680> ?p ?o ?g. }

• W2904871680 abstract "Abstract Focal cortical dysplasia (FCD) is one of the most common pathologies associated with drug-resistant epilepsy (DRE). The pharmacological targets remain obscured, as the molecular mechanisms underlying FCD are unclear. Implications of epigenetically modulated aberrant gene expression in disease progression are reported in various DRE pathologies except FCD. Here we performed genome-wide CpG-DNA methylation profiling by methylated DNA immunoprecipitation (MeDIP) microarray and RNA sequencing (RNAseq) on cortical tissues resected from FCD type II patients. A total of 19088 sites showed altered DNA methylation in all the CpG islands. Of these, 5725 sites were present in the promoter regions, of which 176 genes showed an inverse correlation between methylation and gene expression. Many of these 176 genes were found to belong to a cohesive network of physically interacting proteins linked to several cellular functions. Pathway analysis revealed significant enrichment of receptor tyrosine kinases (RTK), EGFR, PDGFRA, NTRK3, and mTOR signalling pathways. This is the first study that investigates the epigenetic signature associated with FCD type II pathology. The candidate genes and pathways identified in this study may play a crucial role in the regulation of the pathogenic mechanisms of epileptogenesis associated with FCD type II pathologies." @default.
• W2904871680 created "2018-12-22" @default.
• W2904871680 creator A5000188264 @default.
• W2904871680 creator A5009302642 @default.
• W2904871680 creator A5010471658 @default.
• W2904871680 creator A5015474583 @default.
• W2904871680 creator A5015782192 @default.
• W2904871680 creator A5017617516 @default.
• W2904871680 creator A5042654463 @default.
• W2904871680 creator A5062196625 @default.
• W2904871680 creator A5064979397 @default.
• W2904871680 creator A5075215605 @default.
• W2904871680 date "2018-12-19" @default.
• W2904871680 modified "2023-10-11" @default.
• W2904871680 title "Genome-wide DNA Methylation and RNAseq Analyses Identify Aberrant Signalling Pathways in Focal Cortical Dysplasia (FCD) Type II" @default.
• W2904871680 cites W1483653355 @default.
• W2904871680 cites W1519097303 @default.
• W2904871680 cites W1918171614 @default.
• W2904871680 cites W1929006084 @default.
• W2904871680 cites W1934102085 @default.
• W2904871680 cites W1939528805 @default.
• W2904871680 cites W1968458420 @default.
• W2904871680 cites W1972225310 @default.
• W2904871680 cites W1977011113 @default.
• W2904871680 cites W1986584159 @default.
• W2904871680 cites W1987182404 @default.
• W2904871680 cites W1999380027 @default.
• W2904871680 cites W2002161107 @default.
• W2904871680 cites W2008522189 @default.
• W2904871680 cites W2024009242 @default.
• W2904871680 cites W2032610656 @default.
• W2904871680 cites W2046165377 @default.
• W2904871680 cites W2049940943 @default.
• W2904871680 cites W2050224211 @default.
• W2904871680 cites W2055986128 @default.
• W2904871680 cites W2056512892 @default.
• W2904871680 cites W2057068414 @default.
• W2904871680 cites W2059642035 @default.
• W2904871680 cites W2061507445 @default.
• W2904871680 cites W2063332374 @default.
• W2904871680 cites W2073869597 @default.
• W2904871680 cites W2075063616 @default.
• W2904871680 cites W2079356305 @default.
• W2904871680 cites W2079701909 @default.
• W2904871680 cites W2081678861 @default.
• W2904871680 cites W2088399756 @default.
• W2904871680 cites W2089201761 @default.
• W2904871680 cites W2094180636 @default.
• W2904871680 cites W2094539571 @default.
• W2904871680 cites W2110106465 @default.
• W2904871680 cites W2110865347 @default.
• W2904871680 cites W2114570899 @default.
• W2904871680 cites W2133465414 @default.
• W2904871680 cites W2137384928 @default.
• W2904871680 cites W2144628304 @default.
• W2904871680 cites W2147967285 @default.
• W2904871680 cites W2153295642 @default.
• W2904871680 cites W2160692839 @default.
• W2904871680 cites W2166408148 @default.
• W2904871680 cites W2169448800 @default.
• W2904871680 cites W2191319580 @default.
• W2904871680 cites W2215436807 @default.
• W2904871680 cites W2338569631 @default.
• W2904871680 cites W2341328588 @default.
• W2904871680 cites W2517780455 @default.
• W2904871680 cites W2542664757 @default.
• W2904871680 cites W2588172177 @default.
• W2904871680 cites W2595323758 @default.
• W2904871680 cites W40893751 @default.
• W2904871680 doi "https://doi.org/10.1038/s41598-018-35892-5" @default.
• W2904871680 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6299275" @default.
• W2904871680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30568293" @default.
• W2904871680 hasPublicationYear "2018" @default.
• W2904871680 type Work @default.
• W2904871680 sameAs 2904871680 @default.
• W2904871680 citedByCount "22" @default.
• W2904871680 countsByYear W29048716802020 @default.
• W2904871680 countsByYear W29048716802021 @default.
• W2904871680 countsByYear W29048716802022 @default.
• W2904871680 countsByYear W29048716802023 @default.
• W2904871680 crossrefType "journal-article" @default.
• W2904871680 hasAuthorship W2904871680A5000188264 @default.
• W2904871680 hasAuthorship W2904871680A5009302642 @default.
• W2904871680 hasAuthorship W2904871680A5010471658 @default.
• W2904871680 hasAuthorship W2904871680A5015474583 @default.
• W2904871680 hasAuthorship W2904871680A5015782192 @default.
• W2904871680 hasAuthorship W2904871680A5017617516 @default.
• W2904871680 hasAuthorship W2904871680A5042654463 @default.
• W2904871680 hasAuthorship W2904871680A5062196625 @default.
• W2904871680 hasAuthorship W2904871680A5064979397 @default.
• W2904871680 hasAuthorship W2904871680A5075215605 @default.
• W2904871680 hasBestOaLocation W29048716801 @default.
• W2904871680 hasConcept C104317684 @default.
• W2904871680 hasConcept C116114238 @default.
• W2904871680 hasConcept C121912465 @default.
• W2904871680 hasConcept C140173407 @default.
• W2904871680 hasConcept C150194340 @default.
• W2904871680 hasConcept C154253233 @default.
• W2904871680 hasConcept C169760540 @default.
• W2904871680 hasConcept C18431079 @default.

• next