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- W2904902401 abstract "This chapter describes the impact of genomic data on diagnosis, prognosis, and therapy of individual Myelodysplastic syndromes (MDS) patients. (MDS) are a family of clonal hematopoietic stem cell malignancies characterized by ineffective hematopoiesis, peripheral cytopenias, frequent karyotypic abnormalities, and risk of transformation to acute myeloid leukemia (AML). The morphological evaluation of peripheral blood films and bone marrow slides remains the essential method of MDS diagnosis, and it needs a considerable amount of expertise and training. The clinical management of patients with low platelet counts remains challenging and approved chemotherapeutic agents, such as lenalidomide and azacytidine, can also lead to a transient worsening of thrombocytopenia. Thrombocytopenia is an independent factor for decreased survival and has been incorporated in newer prognostic scoring systems. Although limitations exist in the application of precision medicine in MDS, mutation profiling analyses will further improve the classification of MDS and discover new therapeutic biomarkers." @default.
- W2904902401 created "2018-12-22" @default.
- W2904902401 creator A5025476114 @default.
- W2904902401 date "2018-09-03" @default.
- W2904902401 modified "2023-10-18" @default.
- W2904902401 title "Precision medicine in myelodysplastic syndromes" @default.
- W2904902401 cites W4211040570 @default.
- W2904902401 doi "https://doi.org/10.1201/9781315154749-9" @default.
- W2904902401 hasPublicationYear "2018" @default.
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