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- W2904914098 abstract "Castration-resistant prostate cancer is characterized by loss of the androgen inactivation enzyme HSD17B2, emphasizing the importance of intratumoral androgens in tumor progression. Inactive isoforms generated by alternative splicing destabilize the wild-type enzyme, adding steroidogenesis to other prostate cancer drivers that undergo oncogenic splicing, highlighting aberrant splicing as a therapeutic target.See related article by Gao et al., p. 1291." @default.
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- W2904914098 date "2018-12-10" @default.
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- W2904914098 title "Alternative Acts: Oncogenic Splicing of Steroidogenic Enzymes in Prostate Cancer" @default.
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- W2904914098 doi "https://doi.org/10.1158/1078-0432.ccr-18-3410" @default.
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