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- W2904928870 abstract "<br><b>OBJECTIVES:</b> <i>Ichnocarpus frutescens</i> is a common plant used by tribal people and in Ayurveda for its high medicinal value. The purpose of the study was to investigate whether <i>I. frutescens</i> has any persuasive medicinal property to manage diabetes mellitus.<br><b>MATERIALS AND METHODS:</b> Initially, male albino Wistar rats were given intraperitoneal injection of streptozotocin-nicotinamide to induce diabetes, followed with the administration of active fraction obtained from the methanolic extract of <i>I. frutescens</i> for the next 28 consecutive days. Glibenclamide (25 mg/kg) was used as positive control.<br><b>RESULTS:</b> According to the results obtained, active fraction at a dose of 50 mg/kg body weight exhibited significant antihyperglycemic activity, which was evident with reduced blood glucose level up to 58.84%. The active fraction also showed improvement in serum lipid profile as well as regeneration of pancreatic β-cells in diabetic rats. Concurrent histopathological studies reinforce the effect of active fraction in healing pancreas, thus justifying the possible mechanism of its antidiabetic activity.<br><b>CONCLUSION:</b> The results of the present investigation lead credence to the use of <i>I. frutescens</i> in ameliorating the diabetic condition.<br>" @default.
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- W2904928870 date "2018-01-01" @default.
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- W2904928870 title "Antidiabetic potential of active fraction obtained from methanolic extract of Ichnocarpus frutescens: A possible herbal remedy" @default.
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- W2904928870 doi "https://doi.org/10.4103/ijp.ijp_24_18" @default.
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