Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904953313> ?p ?o ?g. }
- W2904953313 endingPage "229" @default.
- W2904953313 startingPage "211" @default.
- W2904953313 abstract "Merkel cell carcinoma (MCC) is a highly aggressive, primary neuroendocrine cancer of the skin. The majority of MCC cases are associated with the recently discovered Merkel cell polyomavirus (MCPyV), while the remaining are caused by ultraviolet (UV) light-induced mutations from excessive sunlight exposure. The risk of developing MCC is much higher in the white population relative to all other races. Approximately 10% of all patients with MCC have some form of immunosuppression including HIV-1/AIDS, chronic inflammatory conditions, solid organ transplantation, or hematological malignancies. The age of onset of MCC is lower and the mortality is higher in immunosuppressed individuals than in immune-competent patients. It is plausible that HIV-1/AIDS predisposes to virus-positive MCC, but it should be noted that HIV-1/AIDS increases the risk for developing of UV-induced skin cancers such as cutaneous squamous cell carcinoma and basal cell carcinoma and therefore may also increase the risk for virus-negative MCC. Surgical management is considered standard of care for localized Merkel cell carcinoma with current recommendations advising a wide local excision of the lesion. Most international guidelines support the use of local adjuvant radiotherapy coupled with tumor staging to improve the frequency of cure. For advanced, metastatic, and recurrent MCC, checkpoint blockade inhibitors targeting PD-1 and PD-L1 have shown remarkable activity including durable long-term. MCC in patients living with HIV-1/AIDS are treated with similar modalities as HIV-1 uninfected individuals with MCC." @default.
- W2904953313 created "2018-12-22" @default.
- W2904953313 creator A5028061559 @default.
- W2904953313 creator A5081560191 @default.
- W2904953313 date "2018-12-07" @default.
- W2904953313 modified "2023-10-17" @default.
- W2904953313 title "Merkel Cell Carcinoma in the HIV-1/AIDS Patient" @default.
- W2904953313 cites W1768939513 @default.
- W2904953313 cites W1892676932 @default.
- W2904953313 cites W1909163072 @default.
- W2904953313 cites W1914106955 @default.
- W2904953313 cites W1968043542 @default.
- W2904953313 cites W1969355897 @default.
- W2904953313 cites W1974203939 @default.
- W2904953313 cites W1976051908 @default.
- W2904953313 cites W1979803486 @default.
- W2904953313 cites W1983317823 @default.
- W2904953313 cites W1984763510 @default.
- W2904953313 cites W1985029955 @default.
- W2904953313 cites W1989209244 @default.
- W2904953313 cites W1989333307 @default.
- W2904953313 cites W1990999464 @default.
- W2904953313 cites W1993301262 @default.
- W2904953313 cites W1993923591 @default.
- W2904953313 cites W1996583727 @default.
- W2904953313 cites W1997242660 @default.
- W2904953313 cites W1999858293 @default.
- W2904953313 cites W2001537500 @default.
- W2904953313 cites W2002541361 @default.
- W2904953313 cites W2007807755 @default.
- W2904953313 cites W2020547644 @default.
- W2904953313 cites W2022093753 @default.
- W2904953313 cites W2024616842 @default.
- W2904953313 cites W2032438721 @default.
- W2904953313 cites W2038413023 @default.
- W2904953313 cites W2040609814 @default.
- W2904953313 cites W2043137363 @default.
- W2904953313 cites W2047012091 @default.
- W2904953313 cites W2048087727 @default.
- W2904953313 cites W2050646399 @default.
- W2904953313 cites W2051186378 @default.
- W2904953313 cites W2055102857 @default.
- W2904953313 cites W2056249547 @default.
- W2904953313 cites W2067486972 @default.
- W2904953313 cites W2068299817 @default.
- W2904953313 cites W2076376431 @default.
- W2904953313 cites W2076963635 @default.
- W2904953313 cites W2079163635 @default.
- W2904953313 cites W2080881269 @default.
- W2904953313 cites W2081386020 @default.
- W2904953313 cites W2085180957 @default.
- W2904953313 cites W2085487956 @default.
- W2904953313 cites W2088547163 @default.
- W2904953313 cites W2089322638 @default.
- W2904953313 cites W2089942634 @default.
- W2904953313 cites W2094306378 @default.
- W2904953313 cites W2096989639 @default.
- W2904953313 cites W2101778284 @default.
- W2904953313 cites W2108496520 @default.
- W2904953313 cites W2111566951 @default.
- W2904953313 cites W2111821144 @default.
- W2904953313 cites W2112718248 @default.
- W2904953313 cites W2118528405 @default.
- W2904953313 cites W2123397339 @default.
- W2904953313 cites W2131352351 @default.
- W2904953313 cites W2132305598 @default.
- W2904953313 cites W2139634296 @default.
- W2904953313 cites W2140463009 @default.
- W2904953313 cites W2140604236 @default.
- W2904953313 cites W2141402931 @default.
- W2904953313 cites W2141924645 @default.
- W2904953313 cites W2143099114 @default.
- W2904953313 cites W2146657218 @default.
- W2904953313 cites W2147145007 @default.
- W2904953313 cites W2154156430 @default.
- W2904953313 cites W2154235714 @default.
- W2904953313 cites W2159249636 @default.
- W2904953313 cites W2160994473 @default.
- W2904953313 cites W2164217903 @default.
- W2904953313 cites W2178996895 @default.
- W2904953313 cites W2184261862 @default.
- W2904953313 cites W2255285412 @default.
- W2904953313 cites W2267572255 @default.
- W2904953313 cites W2270891484 @default.
- W2904953313 cites W2271582895 @default.
- W2904953313 cites W2283046649 @default.
- W2904953313 cites W2313797941 @default.
- W2904953313 cites W2322018349 @default.
- W2904953313 cites W2323470913 @default.
- W2904953313 cites W2333302177 @default.
- W2904953313 cites W2339890238 @default.
- W2904953313 cites W2407801378 @default.
- W2904953313 cites W2415731947 @default.
- W2904953313 cites W2507428959 @default.
- W2904953313 cites W2510686645 @default.
- W2904953313 cites W2516340913 @default.
- W2904953313 cites W2546273436 @default.
- W2904953313 cites W2547701444 @default.