FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904958424> ?p ?o ?g. }

• W2904958424 endingPage "128" @default.
• W2904958424 startingPage "122" @default.
• W2904958424 abstract "Background The chemokine receptor 4 ( CXCR 4) plays an important role in tumor progression. Overexpressed CXCR 4 is associated with a poor prognosis of patient with head and neck squamous cell carcinomas. However, the correlation between CXCR 4 and chemotherapy resistance in tongue squamous cell carcinoma ( TSCC ) remains obscure. Methods Stable cisplatin‐resistant CAL 27 CDDP and SCC 25 CDDP cells were established and identified by CCK 8 assay, and the CXCR 4 expression was detected using qRT ‐ PCR and Western blot. CXCR 4‐si RNA was transfected into TSCC CDDP cells, whose transfect efficiency was examined. Cisplatin sensitivity was further detected, as well as several proliferation and apoptosis‐related proteins. Results CAL 27 CDDP and SCC 25 CDDP cells were successfully established, which exhibited significantly higher cell viability and less apoptosis under cisplatin stimulation than that of parental cells. CXCR 4 expression was increased in TSCC CDDP cells. After transfection of CXCR 4‐si RNA , the expression of CXCR 4 was reduced by 73% and 78% in CAL 27 CDDP and SCC 25 CDDP cells, respectively. CCK 8 assay and flow cytometry assay revealed that the proliferative capacity under cisplatin stimulation significantly decreased after CXCR 4 silencing. Moreover, increased TSCC CDDP cells were arrested in the G0/G1 phase after knockdown of CXCR 4. Compared with negative control group, the expression of cyclin D1 and p‐ AKT decreased, while that of p‐caspase‐3 and Bax significantly increased. Conclusions Silencing CXCR 4 may evidently inhibit proliferation, induce apoptosis and enhance cisplatin sensitivity of TSCC CDDP cells by reduced cyclin D1 and p‐ AKT , and increased p‐caspase‐3 and Bax." @default.
• W2904958424 created "2018-12-22" @default.
• W2904958424 creator A5065326394 @default.
• W2904958424 creator A5078867858 @default.
• W2904958424 date "2018-12-30" @default.
• W2904958424 modified "2023-09-25" @default.
• W2904958424 title "CXCR 4 enhances cisplatin resistance of human tongue squamous cell carcinoma" @default.
• W2904958424 cites W1604362135 @default.
• W2904958424 cites W1913709492 @default.
• W2904958424 cites W1988043615 @default.
• W2904958424 cites W1999503941 @default.
• W2904958424 cites W2001608888 @default.
• W2904958424 cites W2008314452 @default.
• W2904958424 cites W2009627966 @default.
• W2904958424 cites W2027604384 @default.
• W2904958424 cites W2029980617 @default.
• W2904958424 cites W2031047333 @default.
• W2904958424 cites W2036178581 @default.
• W2904958424 cites W2051856733 @default.
• W2904958424 cites W2108353340 @default.
• W2904958424 cites W2121291985 @default.
• W2904958424 cites W2122527978 @default.
• W2904958424 cites W2131665195 @default.
• W2904958424 cites W2137457318 @default.
• W2904958424 cites W2155481710 @default.
• W2904958424 cites W2175142598 @default.
• W2904958424 cites W2470369062 @default.
• W2904958424 cites W2514314694 @default.
• W2904958424 cites W2516105971 @default.
• W2904958424 cites W2771379749 @default.
• W2904958424 cites W2804177971 @default.
• W2904958424 cites W944137381 @default.
• W2904958424 doi "https://doi.org/10.1111/jop.12813" @default.
• W2904958424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30554431" @default.
• W2904958424 hasPublicationYear "2018" @default.
• W2904958424 type Work @default.
• W2904958424 sameAs 2904958424 @default.
• W2904958424 citedByCount "8" @default.
• W2904958424 countsByYear W29049584242019 @default.
• W2904958424 countsByYear W29049584242020 @default.
• W2904958424 countsByYear W29049584242021 @default.
• W2904958424 countsByYear W29049584242022 @default.
• W2904958424 crossrefType "journal-article" @default.
• W2904958424 hasAuthorship W2904958424A5065326394 @default.
• W2904958424 hasAuthorship W2904958424A5078867858 @default.
• W2904958424 hasConcept C126322002 @default.
• W2904958424 hasConcept C153911025 @default.
• W2904958424 hasConcept C190283241 @default.
• W2904958424 hasConcept C199835354 @default.
• W2904958424 hasConcept C22615655 @default.
• W2904958424 hasConcept C2776694085 @default.
• W2904958424 hasConcept C2778239845 @default.
• W2904958424 hasConcept C29537977 @default.
• W2904958424 hasConcept C502942594 @default.
• W2904958424 hasConcept C54009773 @default.
• W2904958424 hasConcept C54355233 @default.
• W2904958424 hasConcept C553184892 @default.
• W2904958424 hasConcept C55493867 @default.
• W2904958424 hasConcept C62112901 @default.
• W2904958424 hasConcept C71924100 @default.
• W2904958424 hasConcept C81885089 @default.
• W2904958424 hasConcept C86803240 @default.
• W2904958424 hasConceptScore W2904958424C126322002 @default.
• W2904958424 hasConceptScore W2904958424C153911025 @default.
• W2904958424 hasConceptScore W2904958424C190283241 @default.
• W2904958424 hasConceptScore W2904958424C199835354 @default.
• W2904958424 hasConceptScore W2904958424C22615655 @default.
• W2904958424 hasConceptScore W2904958424C2776694085 @default.
• W2904958424 hasConceptScore W2904958424C2778239845 @default.
• W2904958424 hasConceptScore W2904958424C29537977 @default.
• W2904958424 hasConceptScore W2904958424C502942594 @default.
• W2904958424 hasConceptScore W2904958424C54009773 @default.
• W2904958424 hasConceptScore W2904958424C54355233 @default.
• W2904958424 hasConceptScore W2904958424C553184892 @default.
• W2904958424 hasConceptScore W2904958424C55493867 @default.
• W2904958424 hasConceptScore W2904958424C62112901 @default.
• W2904958424 hasConceptScore W2904958424C71924100 @default.
• W2904958424 hasConceptScore W2904958424C81885089 @default.
• W2904958424 hasConceptScore W2904958424C86803240 @default.
• W2904958424 hasFunder F4320321001 @default.
• W2904958424 hasIssue "2" @default.
• W2904958424 hasLocation W29049584241 @default.
• W2904958424 hasLocation W29049584242 @default.
• W2904958424 hasOpenAccess W2904958424 @default.
• W2904958424 hasPrimaryLocation W29049584241 @default.
• W2904958424 hasRelatedWork W2345180005 @default.
• W2904958424 hasRelatedWork W2348182528 @default.
• W2904958424 hasRelatedWork W2350294409 @default.
• W2904958424 hasRelatedWork W2354128257 @default.
• W2904958424 hasRelatedWork W2379033026 @default.
• W2904958424 hasRelatedWork W2386243369 @default.
• W2904958424 hasRelatedWork W2386797884 @default.
• W2904958424 hasRelatedWork W3031159451 @default.
• W2904958424 hasRelatedWork W3031579642 @default.
• W2904958424 hasRelatedWork W3032847486 @default.
• W2904958424 hasVolume "48" @default.
• W2904958424 isParatext "false" @default.
• W2904958424 isRetracted "false" @default.

• next