FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904968560> ?p ?o ?g. }

• W2904968560 abstract "Lyme arthritis (LA), a late disease manifestation of Borrelia burgdorferi infection, usually resolves with antibiotic therapy. However, some patients develop proliferative synovitis lasting months to several years after spirochetal killing, called postinfectious LA. In this study, we phenotyped haematopoietic and stromal cell populations in the synovial lesion ex vivo and used these findings to generate an in vitro model of LA using patient-derived fibroblast-like synoviocytes (FLS). Ex vivo analysis of synovial tissue revealed high abundance of IFNγ-producing T cells and NK cells. Similar to marked IFNγ responses in tissue, postinfectious LA synovial fluid also had high levels of IFNγ. HLA-DR-positive FLS were present throughout the synovial lesion, particularly in areas of inflammation. FLS stimulated in vitro with B. burgdorferi, which were similar to conditions during infection, expressed 68 genes associated primarily with innate immune activation and neutrophil recruitment. In contrast, FLS stimulated with IFNγ, which were similar to conditions in the postinfectious phase, expressed >2,000 genes associated with pathogen sensing, inflammation, and MHC Class II antigen presentation, similar to the expression profile in postinfectious synovial tissue. Furthermore, costimulation of FLS with B. burgdorferi and IFNγ induced greater expression of IL-6 and other innate immune response proteins and genes than with IFNγ stimulation alone. These results suggest that B. burgdorferi infection, in combination with IFNγ, initiates the differentiation of FLS into a highly inflammatory phenotype. We hypothesise that overexpression of IFNγ by lymphocytes within synovia perpetuates these responses in the postinfectious period, causing proliferative synovitis and stalling appropriate repair of damaged tissue." @default.
• W2904968560 created "2018-12-22" @default.
• W2904968560 creator A5001175561 @default.
• W2904968560 creator A5014184589 @default.
• W2904968560 creator A5017448244 @default.
• W2904968560 creator A5021899696 @default.
• W2904968560 creator A5035630435 @default.
• W2904968560 creator A5044109373 @default.
• W2904968560 creator A5071151203 @default.
• W2904968560 creator A5072895172 @default.
• W2904968560 creator A5081954285 @default.
• W2904968560 date "2019-01-04" @default.
• W2904968560 modified "2023-10-18" @default.
• W2904968560 title "Interferon‐gamma production in Lyme arthritis synovial tissue promotes differentiation of fibroblast‐like synoviocytes into immune effector cells" @default.
• W2904968560 cites W1566617354 @default.
• W2904968560 cites W1600792033 @default.
• W2904968560 cites W1732905722 @default.
• W2904968560 cites W1922109339 @default.
• W2904968560 cites W1975608178 @default.
• W2904968560 cites W1976177645 @default.
• W2904968560 cites W1988356259 @default.
• W2904968560 cites W2000468514 @default.
• W2904968560 cites W2001449987 @default.
• W2904968560 cites W2016216159 @default.
• W2904968560 cites W2019431037 @default.
• W2904968560 cites W2025290253 @default.
• W2904968560 cites W2025609755 @default.
• W2904968560 cites W2038444567 @default.
• W2904968560 cites W2050804496 @default.
• W2904968560 cites W2076357723 @default.
• W2904968560 cites W2078836325 @default.
• W2904968560 cites W2079274075 @default.
• W2904968560 cites W2122187426 @default.
• W2904968560 cites W2128952811 @default.
• W2904968560 cites W2132349575 @default.
• W2904968560 cites W2133866452 @default.
• W2904968560 cites W2136553001 @default.
• W2904968560 cites W2138685988 @default.
• W2904968560 cites W2141188002 @default.
• W2904968560 cites W2145981344 @default.
• W2904968560 cites W2153064758 @default.
• W2904968560 cites W2155702314 @default.
• W2904968560 cites W2158217645 @default.
• W2904968560 cites W2159482845 @default.
• W2904968560 cites W2286099853 @default.
• W2904968560 cites W2528261430 @default.
• W2904968560 cites W2530948814 @default.
• W2904968560 cites W2576807615 @default.
• W2904968560 cites W2577901620 @default.
• W2904968560 cites W2607154592 @default.
• W2904968560 cites W2760839237 @default.
• W2904968560 cites W2780173227 @default.
• W2904968560 cites W2783615160 @default.
• W2904968560 cites W2804499079 @default.
• W2904968560 cites W2804716665 @default.
• W2904968560 cites W2890199122 @default.
• W2904968560 cites W4246497484 @default.
• W2904968560 cites W4249574740 @default.
• W2904968560 cites W4294216483 @default.
• W2904968560 cites W886852655 @default.
• W2904968560 doi "https://doi.org/10.1111/cmi.12992" @default.
• W2904968560 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6336510" @default.
• W2904968560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30550623" @default.
• W2904968560 hasPublicationYear "2019" @default.
• W2904968560 type Work @default.
• W2904968560 sameAs 2904968560 @default.
• W2904968560 citedByCount "22" @default.
• W2904968560 countsByYear W29049685602019 @default.
• W2904968560 countsByYear W29049685602020 @default.
• W2904968560 countsByYear W29049685602021 @default.
• W2904968560 countsByYear W29049685602022 @default.
• W2904968560 countsByYear W29049685602023 @default.
• W2904968560 crossrefType "journal-article" @default.
• W2904968560 hasAuthorship W2904968560A5001175561 @default.
• W2904968560 hasAuthorship W2904968560A5014184589 @default.
• W2904968560 hasAuthorship W2904968560A5017448244 @default.
• W2904968560 hasAuthorship W2904968560A5021899696 @default.
• W2904968560 hasAuthorship W2904968560A5035630435 @default.
• W2904968560 hasAuthorship W2904968560A5044109373 @default.
• W2904968560 hasAuthorship W2904968560A5071151203 @default.
• W2904968560 hasAuthorship W2904968560A5072895172 @default.
• W2904968560 hasAuthorship W2904968560A5081954285 @default.
• W2904968560 hasBestOaLocation W29049685601 @default.
• W2904968560 hasConcept C136449434 @default.
• W2904968560 hasConcept C150903083 @default.
• W2904968560 hasConcept C159654299 @default.
• W2904968560 hasConcept C203014093 @default.
• W2904968560 hasConcept C207001950 @default.
• W2904968560 hasConcept C26291073 @default.
• W2904968560 hasConcept C2776914184 @default.
• W2904968560 hasConcept C2777077863 @default.
• W2904968560 hasConcept C2777652487 @default.
• W2904968560 hasConcept C2779159148 @default.
• W2904968560 hasConcept C2779244835 @default.
• W2904968560 hasConcept C2908660692 @default.
• W2904968560 hasConcept C86803240 @default.
• W2904968560 hasConcept C8891405 @default.
• W2904968560 hasConceptScore W2904968560C136449434 @default.
• W2904968560 hasConceptScore W2904968560C150903083 @default.
• W2904968560 hasConceptScore W2904968560C159654299 @default.

• next