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- W2904990852 endingPage "930" @default.
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- W2904990852 abstract "Tablets, compression coated with certain polysaccharides and intended for colon delivery, retain the integrity of the coat for an initial period of about 6 h (lag period) beyond which (post-lag period) the coat is degraded by colonic enzymes to induce drug release. This work was undertaken to investigate the factors which influence the integrity of the coat during the lag period. Core tablets containing two model drugs were compression coated with various amounts of carboxymethyl locust bean gum (CMLBG). In-vitro release of drugs, erosion of coat, and steady shear viscosity of CMLBG solutions having different concentrations and solution pH were determined. The viscosity of CMLBG that depended primarily on CMLBG concentration and partly on solution pH was responsible for erosion and integrity of the coat in the lag period. Evaluation of polymer viscosity could describe the integrity of coat of a polysaccharide coated tablet in the lag period." @default.
- W2904990852 created "2018-12-22" @default.
- W2904990852 creator A5040792770 @default.
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- W2904990852 date "2019-03-01" @default.
- W2904990852 modified "2023-10-13" @default.
- W2904990852 title "Effect of polymer concentration and solution pH on viscosity affecting integrity of a polysaccharide coat of compression coated tablets" @default.
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- W2904990852 doi "https://doi.org/10.1016/j.ijbiomac.2018.12.101" @default.
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