FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904991971> ?p ?o ?g. }

• W2904991971 abstract "Germinal matrix-intraventricular haemorrhage (GMH-IVH) remains a substantial issue in neonatal intensive care units worldwide. Current therapies to prevent or treat GMH-IVH are limited. Stem cell-based therapies offer a potential therapeutic approach to repair, restore, and/or regenerate injured brain tissue. These preclinical findings have now culminated in ongoing human neonatal studies.To determine the benefits and harms of stem cell-based interventions for prevention or treatment of germinal matrix-intraventricular haemorrhage (GM-IVH) in preterm infants.We used the standard search strategy of Cochrane Neonatal to search the Cochrane Central Register of Controlled Trials (CENTRAL; 2019, Issue 1), in the Cochrane Library; MEDLINE via PubMed (1966 to 7 January 2019); Embase (1980 to 7 January 2019); and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) (1982 to 7 January 2019). We also searched clinical trials databases, conference proceedings, and reference lists of retrieved articles for randomised controlled trials and quasi-randomised trials.We attempted to identify randomised controlled trials, quasi-randomised controlled trials, and cluster trials comparing (1) stem cell-based interventions versus control; (2) mesenchymal stromal cells (MSCs) of type or source versus MSCs of other type or source; (3) stem cell-based interventions other than MSCs of type or source versus stem cell-based interventions other than MSCs of other type or source; or (4) MSCs versus stem cell-based interventions other than MSCs. For prevention studies, we included extremely preterm infants (less than 28 weeks' gestation), 24 hours of age or less, without ultrasound diagnosis of GM-IVH; for treatment studies, we included preterm infants (less than 37 weeks' gestation), of any postnatal age, with ultrasound diagnosis of GM-IVH.For each of the included trials, two review authors independently planned to extract data (e.g. number of participants, birth weight, gestational age, type and source of MSCs, other stem cell-based interventions) and assess the risk of bias (e.g. adequacy of randomisation, blinding, completeness of follow-up). Primary outcomes considered in this review are all-cause neonatal mortality, major neurodevelopmental disability, GM-IVH, and extension of pre-existing non-severe GM-IVH. We planned to use the GRADE approach to assess the quality of evidence.Our search strategy yielded 769 references. We did not find any completed studies for inclusion. One randomised controlled trial is currently registered and ongoing. Five phase 1 trials are described in the excluded studies.Currently no evidence is available to show the benefits or harms of stem cell-based interventions for treatment or prevention of GM-IVH in preterm infants." @default.
• W2904991971 created "2018-12-22" @default.
• W2904991971 creator A5004740584 @default.
• W2904991971 creator A5038712369 @default.
• W2904991971 creator A5049802907 @default.
• W2904991971 creator A5051439307 @default.
• W2904991971 creator A5051658775 @default.
• W2904991971 date "2019-09-24" @default.
• W2904991971 modified "2023-09-30" @default.
• W2904991971 title "Stem cell-based interventions for the prevention and treatment of germinal matrix-intraventricular haemorrhage in preterm infants" @default.
• W2904991971 cites W1075879239 @default.
• W2904991971 cites W1522787362 @default.
• W2904991971 cites W1547740703 @default.
• W2904991971 cites W1548585019 @default.
• W2904991971 cites W1600024584 @default.
• W2904991971 cites W1669794305 @default.
• W2904991971 cites W1830337612 @default.
• W2904991971 cites W1846517983 @default.
• W2904991971 cites W1859539904 @default.
• W2904991971 cites W1896545635 @default.
• W2904991971 cites W1914128451 @default.
• W2904991971 cites W1962292479 @default.
• W2904991971 cites W1967824323 @default.
• W2904991971 cites W1968509137 @default.
• W2904991971 cites W1974659683 @default.
• W2904991971 cites W1975434115 @default.
• W2904991971 cites W1980229529 @default.
• W2904991971 cites W1990453411 @default.
• W2904991971 cites W1993251930 @default.
• W2904991971 cites W1998463679 @default.
• W2904991971 cites W2001546302 @default.
• W2904991971 cites W2002007761 @default.
• W2904991971 cites W2004275927 @default.
• W2904991971 cites W2004294547 @default.
• W2904991971 cites W2005943573 @default.
• W2904991971 cites W2005962589 @default.
• W2904991971 cites W2007644749 @default.
• W2904991971 cites W2012311363 @default.
• W2904991971 cites W2016174014 @default.
• W2904991971 cites W2017584345 @default.
• W2904991971 cites W2019549525 @default.
• W2904991971 cites W2020122595 @default.
• W2904991971 cites W2021027411 @default.
• W2904991971 cites W2025371271 @default.
• W2904991971 cites W2027540026 @default.
• W2904991971 cites W2027994633 @default.
• W2904991971 cites W2030218561 @default.
• W2904991971 cites W2031790029 @default.
• W2904991971 cites W2033868268 @default.
• W2904991971 cites W2037177143 @default.
• W2904991971 cites W2038811316 @default.
• W2904991971 cites W2040091260 @default.
• W2904991971 cites W2041204445 @default.
• W2904991971 cites W2041425138 @default.
• W2904991971 cites W2045757887 @default.
• W2904991971 cites W2046224474 @default.
• W2904991971 cites W2046224781 @default.
• W2904991971 cites W2046237540 @default.
• W2904991971 cites W2048995627 @default.
• W2904991971 cites W2049446122 @default.
• W2904991971 cites W2051879624 @default.
• W2904991971 cites W2053177057 @default.
• W2904991971 cites W2056040676 @default.
• W2904991971 cites W2057382222 @default.
• W2904991971 cites W2068318662 @default.
• W2904991971 cites W2069945130 @default.
• W2904991971 cites W2071221548 @default.
• W2904991971 cites W2074084795 @default.
• W2904991971 cites W2080594447 @default.
• W2904991971 cites W2083540409 @default.
• W2904991971 cites W2084652685 @default.
• W2904991971 cites W2085326091 @default.
• W2904991971 cites W2086215394 @default.
• W2904991971 cites W2087145590 @default.
• W2904991971 cites W2090641592 @default.
• W2904991971 cites W2091423694 @default.
• W2904991971 cites W2091923948 @default.
• W2904991971 cites W2092325185 @default.
• W2904991971 cites W2094102897 @default.
• W2904991971 cites W2094273520 @default.
• W2904991971 cites W2101674239 @default.
• W2904991971 cites W2109624311 @default.
• W2904991971 cites W2111447973 @default.
• W2904991971 cites W2112140599 @default.
• W2904991971 cites W2115299328 @default.
• W2904991971 cites W2122952930 @default.
• W2904991971 cites W2125435699 @default.
• W2904991971 cites W2134125531 @default.
• W2904991971 cites W2135776201 @default.
• W2904991971 cites W2137788719 @default.
• W2904991971 cites W2142594288 @default.
• W2904991971 cites W2143627246 @default.
• W2904991971 cites W2144837687 @default.
• W2904991971 cites W2156098321 @default.
• W2904991971 cites W2156897439 @default.
• W2904991971 cites W2157823046 @default.
• W2904991971 cites W2164320832 @default.
• W2904991971 cites W2164964624 @default.
• W2904991971 cites W2165695867 @default.
• W2904991971 cites W2170524561 @default.

• next