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- W2904992454 abstract "Vitamin B6 comprises six compounds based on a 2-methyl-3-hydroxypyridine structure with differing subunits at positions C4 and C5 that are interconvertible. These are pyridoxine, pyridoxamine, and pyridoxal and their phosphorylated derivatives pyridoxine-5-phosphate, pyridoxamine-5-phosphate, and pyridoxal-5-phosphate (PLP). PLP is a cofactor in > 150 different enzyme reactions including transamination and decarboxylation enzyme systems. The symptoms of vitamin B6 deficiency include peripheral neuropathy, pellagra-like syndrome with seborrheic dermatitis and glossitis. Prolonged deficiency can lead to depression, confusion, and in severe cases causes abnormalities in EEG signals and seizures. The assessment of vitamin B6 status can be undertaken through direct measurement of vitamin B6 compounds or using indirect markers that reflect the effect of deficiency on the various pathways involving PLP-dependent enzymes, e.g., kynurenines, transaminases, and various amino acids." @default.
- W2904992454 created "2018-12-22" @default.
- W2904992454 creator A5082595747 @default.
- W2904992454 date "2019-01-01" @default.
- W2904992454 modified "2023-10-18" @default.
- W2904992454 title "Methods for assessment of Vitamin B6" @default.
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- W2904992454 doi "https://doi.org/10.1016/b978-0-12-813050-6.00009-7" @default.
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