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- W2904994271 abstract "Abstract Pyrroloquinoline quinone (PQQ) acts as a powerful modulator of PGC‐1α activation and therefore regulates multiple pathways involved in cellular energy homeostasis. In the present study, we assessed the effects of L6 myotubes incubation with 0.5, 1, and 3 μM PQQ solution for 2 and 24 hr with respect to the cells' lipid metabolism. We demonstrated that PQQ significantly elevates PGC‐1α content in a dose‐ and time‐dependent manner with the highest efficiency for 0.5 and 1 µM. The level of free fatty acids was diminished (24 hr: −66%), while an increase in triacylglycerol (TAG) amount was most pronounced after 0.5 μM (2 hr: +93%, 24 hr: +139%) treatment. Ceramide (CER) content was elevated after 2 hr incubation with 0.5 µM and after prolonged exposure to all PQQ concentrations. The cells treated with PQQ for 2 hr exhibited decreased sphinganine (SFA) and sphinganine‐1‐phosphate (SFA1P) level, while 24 hr incubation resulted in an elevated sphingosine (SFO) amount. In summary, PGC‐1α activation promotes TAG and CER synthesis." @default.
- W2904994271 created "2018-12-22" @default.
- W2904994271 creator A5011061108 @default.
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- W2904994271 date "2018-12-06" @default.
- W2904994271 modified "2023-10-16" @default.
- W2904994271 title "Dose‐ and time‐dependent alterations in lipid metabolism after pharmacological PGC‐1α activation in L6 myotubes" @default.
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- W2904994271 doi "https://doi.org/10.1002/jcp.27872" @default.
- W2904994271 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6587770" @default.
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- W2904994271 hasPublicationYear "2018" @default.
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