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- W2904994372 abstract "Photodynamic therapy (PDT) is a non-invasive, selective, and cost-effective cancer therapy. The development of readily accessible templates that allow rapid structural modification for further improvement of PDT remains important. We previously reported thiophene-based organic D-π-A sensitizers consisted of an electron-donating (D) moiety, a π-conjugated bridge (π) moiety, and an electron-accepting (A) moiety as valuable templates for a photosensitizer that can be used in PDT. Our preliminary structure-activity relationship study revealed that the structure of the A moiety significantly influences its phototoxicity. In this study, we evaluated the photoabsorptive, cellular uptake, and photo-oxidizing abilities of D-π-A sensitizers that contained different A moieties. The level of phototoxicity of the D-π-A sensitizers was rationalized by considering those three abilities. In addition, we observed the ability of amphiphilic sensitizers containing either a carboxylic acid or an amide in an A moiety to form aggregates that penetrate cells mainly via endocytosis." @default.
- W2904994372 created "2018-12-22" @default.
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- W2904994372 date "2019-01-01" @default.
- W2904994372 modified "2023-09-26" @default.
- W2904994372 title "Elucidating the mode of action for thiophene-based organic D-π-A sensitizers for use in photodynamic therapy" @default.
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- W2904994372 doi "https://doi.org/10.1016/j.bmc.2018.12.006" @default.
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