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• W2904994609 abstract "The γ-lactam motif is often found in naturally occurring compounds with diverse biological activities. We prepared a 28-member library of N-substituted γ-lactams following a single-pot, three-component Ugi reaction comprising bifunctional building block, l-glutamic acid methyl ester. The reaction tolerates structurally diverse carbonyl and isocyanide components providing a robust access to functionalized γ-lactams. Antimicrobial susceptibility testing, including agar well diffusion assay, serial microdilution broth assay, and antibiofilm activity testing, identified a potent compound with antibiofilm activity against Staphylococcus aureus ATCC 6538." @default.
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• W2904994609 date "2018-12-18" @default.
• W2904994609 modified "2023-10-07" @default.
• W2904994609 title "Multicomponent Approach to a Library of <i>N</i>-Substituted γ-Lactams" @default.
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• W2904994609 doi "https://doi.org/10.1021/acscombsci.8b00147" @default.
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