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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905018573> ?p ?o ?g. }

• W2905018573 abstract "RSV is an important cause of LRTI in infants and young children for which there are no suitable antiviral drugs offered. We evaluated the efficacy of KPT-335 as an anti-RSV drug and show that KPT-335 inhibits XPO1-mediated nuclear export, leading to nuclear accumulation of RSV M protein and reduction in RSV levels. KPT-335 treatment also resulted in inhibition of proinflammatory pathways, which has important implications for its effectiveness in vivo ." @default.
• W2905018573 created "2018-12-22" @default.
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• W2905018573 date "2019-02-15" @default.
• W2905018573 modified "2023-10-14" @default.
• W2905018573 title "Verdinexor (KPT-335), a Selective Inhibitor of Nuclear Export, Reduces Respiratory Syncytial Virus Replication <i>In Vitro</i>" @default.
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• W2905018573 doi "https://doi.org/10.1128/jvi.01684-18" @default.
• W2905018573 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6364025" @default.
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• W2905018573 hasPublicationYear "2019" @default.
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