FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905055461> ?p ?o ?g. }

• W2905055461 abstract "Obesity and high fat diet consumption contribute to the development of metabolic disorders, insulin resistance, neuroinflammation, and cognitive impairments. CNS administration of insulin into the brain can attenuate these cognitive impairments. The present study investigated whether hippocampal-dependent spatial memory impairments in a dietary induced mouse model of obesity could be improved by the direct administration of insulin into the hippocampus and whether this was associated with markers of hippocampal inflammation. C57Bl/6J mice consumed a low fat or high fat diet for 16 weeks and continuous intrahippocampal saline or insulin infusion for the final 4 weeks, during a period of behavioural testing, before gene expression analysis was performed. The high fat diet group demonstrated poorer spatial memory performance in the Morris water maze and Y-maze, supporting the hypothesis that high fat diet leads to hippocampal dependent cognitive impairment. Insulin infusion into the hippocampus reversed the deficit of high fat diet consumption on both of the tasks. Increased expression of inflammatory markers was detected in the hippocampus in the high fat diet group and expression of these markers was ameliorated in insulin infused mice. This demonstrates that CNS insulin can improve hippocampal-dependent memory and that hippocampal inflammation may be a factor in the development of cognitive deficits associated with diet-induced obesity. Furthermore, these data suggest that insulin may act to attenuate high fat diet induced cognitive deficits by reducing neuroinflammation." @default.
• W2905055461 created "2018-12-22" @default.
• W2905055461 creator A5012033497 @default.
• W2905055461 creator A5028862826 @default.
• W2905055461 creator A5053336404 @default.
• W2905055461 creator A5071347365 @default.
• W2905055461 creator A5077656621 @default.
• W2905055461 date "2018-12-11" @default.
• W2905055461 modified "2023-09-26" @default.
• W2905055461 title "The Effect of Intrahippocampal Insulin Infusion on Spatial Cognitive Function and Markers of Neuroinflammation in Diet-induced Obesity" @default.
• W2905055461 cites W1518051697 @default.
• W2905055461 cites W1786517400 @default.
• W2905055461 cites W1827489356 @default.
• W2905055461 cites W1971911315 @default.
• W2905055461 cites W1974025074 @default.
• W2905055461 cites W1976048196 @default.
• W2905055461 cites W1987478242 @default.
• W2905055461 cites W1991856249 @default.
• W2905055461 cites W1992431456 @default.
• W2905055461 cites W1993304062 @default.
• W2905055461 cites W1994580609 @default.
• W2905055461 cites W1995248718 @default.
• W2905055461 cites W2000209446 @default.
• W2905055461 cites W2004346418 @default.
• W2905055461 cites W2007371413 @default.
• W2905055461 cites W2015016479 @default.
• W2905055461 cites W2020191402 @default.
• W2905055461 cites W2020809584 @default.
• W2905055461 cites W2030426953 @default.
• W2905055461 cites W2035230006 @default.
• W2905055461 cites W2037427415 @default.
• W2905055461 cites W2037825383 @default.
• W2905055461 cites W2046140771 @default.
• W2905055461 cites W2049616256 @default.
• W2905055461 cites W2049871798 @default.
• W2905055461 cites W2056448740 @default.
• W2905055461 cites W2064836594 @default.
• W2905055461 cites W2065520135 @default.
• W2905055461 cites W2067902437 @default.
• W2905055461 cites W2069550725 @default.
• W2905055461 cites W2070381267 @default.
• W2905055461 cites W2076760455 @default.
• W2905055461 cites W2083677329 @default.
• W2905055461 cites W2087443596 @default.
• W2905055461 cites W2087931458 @default.
• W2905055461 cites W2090409064 @default.
• W2905055461 cites W2090868261 @default.
• W2905055461 cites W2094448862 @default.
• W2905055461 cites W2095717717 @default.
• W2905055461 cites W2101048381 @default.
• W2905055461 cites W2114346250 @default.
• W2905055461 cites W2119795049 @default.
• W2905055461 cites W2120667767 @default.
• W2905055461 cites W2123541107 @default.
• W2905055461 cites W2124244382 @default.
• W2905055461 cites W2135456335 @default.
• W2905055461 cites W2135591161 @default.
• W2905055461 cites W2145107163 @default.
• W2905055461 cites W2146978742 @default.
• W2905055461 cites W2149400891 @default.
• W2905055461 cites W2151845878 @default.
• W2905055461 cites W2152930178 @default.
• W2905055461 cites W2154982924 @default.
• W2905055461 cites W2163710303 @default.
• W2905055461 cites W2163772343 @default.
• W2905055461 cites W2177541242 @default.
• W2905055461 cites W2205233891 @default.
• W2905055461 cites W2271925893 @default.
• W2905055461 cites W2296915958 @default.
• W2905055461 cites W2332819904 @default.
• W2905055461 cites W2341244791 @default.
• W2905055461 cites W2550589597 @default.
• W2905055461 cites W2611673484 @default.
• W2905055461 cites W4248694092 @default.
• W2905055461 cites W619798833 @default.
• W2905055461 doi "https://doi.org/10.3389/fendo.2018.00752" @default.
• W2905055461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6297211" @default.
• W2905055461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30619085" @default.
• W2905055461 hasPublicationYear "2018" @default.
• W2905055461 type Work @default.
• W2905055461 sameAs 2905055461 @default.
• W2905055461 citedByCount "24" @default.
• W2905055461 countsByYear W29050554612019 @default.
• W2905055461 countsByYear W29050554612020 @default.
• W2905055461 countsByYear W29050554612021 @default.
• W2905055461 countsByYear W29050554612022 @default.
• W2905055461 countsByYear W29050554612023 @default.
• W2905055461 crossrefType "journal-article" @default.
• W2905055461 hasAuthorship W2905055461A5012033497 @default.
• W2905055461 hasAuthorship W2905055461A5028862826 @default.
• W2905055461 hasAuthorship W2905055461A5053336404 @default.
• W2905055461 hasAuthorship W2905055461A5071347365 @default.
• W2905055461 hasAuthorship W2905055461A5077656621 @default.
• W2905055461 hasBestOaLocation W29050554611 @default.
• W2905055461 hasConcept C126322002 @default.
• W2905055461 hasConcept C134018914 @default.
• W2905055461 hasConcept C148762608 @default.
• W2905055461 hasConcept C15744967 @default.
• W2905055461 hasConcept C2776914184 @default.
• W2905055461 hasConcept C2777391703 @default.

• next