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• W2905061486 abstract "Potent estrogen receptor ligands typically contain a phenolic hydrogen-bond donor. The indazole of the selective estrogen receptor degrader (SERD) ARN-810 is believed to mimic this. Disclosed herein is the discovery of ARN-810 analogs which lack this hydrogen-bond donor. These SERDs induced tumor regression in a tamoxifen-resistant breast cancer xenograft, demonstrating that the indazole NH is not necessary for robust ER-modulation and anti-tumor activity." @default.
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• W2905061486 date "2019-02-01" @default.
• W2905061486 modified "2023-09-26" @default.
• W2905061486 title "Selective estrogen receptor degraders with novel structural motifs induce regression in a tamoxifen-resistant breast cancer xenograft" @default.
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• W2905061486 doi "https://doi.org/10.1016/j.bmcl.2018.12.042" @default.
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