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- W2905067650 abstract "Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-induced myokine released on cleavage of the membrane-bound precursor protein fibronectin type III domain-containing protein 5 (FNDC5), also expressed in the hippocampus. Here we show that FNDC5/irisin levels are reduced in AD hippocampi and cerebrospinal fluid, and in experimental AD models. Knockdown of brain FNDC5/irisin impairs long-term potentiation and novel object recognition memory in mice. Conversely, boosting brain levels of FNDC5/irisin rescues synaptic plasticity and memory in AD mouse models. Peripheral overexpression of FNDC5/irisin rescues memory impairment, whereas blockade of either peripheral or brain FNDC5/irisin attenuates the neuroprotective actions of physical exercise on synaptic plasticity and memory in AD mice. By showing that FNDC5/irisin is an important mediator of the beneficial effects of exercise in AD models, our findings place FNDC5/irisin as a novel agent capable of opposing synapse failure and memory impairment in AD." @default.
- W2905067650 created "2018-12-22" @default.
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- W2905067650 date "2019-01-01" @default.
- W2905067650 modified "2023-10-10" @default.
- W2905067650 title "Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models" @default.
- W2905067650 cites W1520284233 @default.
- W2905067650 cites W1570236416 @default.
- W2905067650 cites W1574405090 @default.
- W2905067650 cites W1597116068 @default.
- W2905067650 cites W1649091845 @default.
- W2905067650 cites W1774383189 @default.
- W2905067650 cites W1970164987 @default.
- W2905067650 cites W1975141413 @default.
- W2905067650 cites W1982795519 @default.
- W2905067650 cites W1990078328 @default.
- W2905067650 cites W2001692959 @default.
- W2905067650 cites W2004632368 @default.
- W2905067650 cites W2005355670 @default.
- W2905067650 cites W2007265598 @default.
- W2905067650 cites W2015620326 @default.
- W2905067650 cites W2022529246 @default.
- W2905067650 cites W2034126231 @default.
- W2905067650 cites W2034632760 @default.
- W2905067650 cites W2034986487 @default.
- W2905067650 cites W2041183431 @default.
- W2905067650 cites W2042751066 @default.
- W2905067650 cites W2051303611 @default.
- W2905067650 cites W2053665966 @default.
- W2905067650 cites W2059119812 @default.
- W2905067650 cites W2061313710 @default.
- W2905067650 cites W2067443877 @default.
- W2905067650 cites W2069048337 @default.
- W2905067650 cites W2069381818 @default.
- W2905067650 cites W2077464099 @default.
- W2905067650 cites W2077569942 @default.
- W2905067650 cites W2078212921 @default.
- W2905067650 cites W2079838847 @default.
- W2905067650 cites W2084746466 @default.
- W2905067650 cites W2085397620 @default.
- W2905067650 cites W2094118946 @default.
- W2905067650 cites W2107277218 @default.
- W2905067650 cites W2112941027 @default.
- W2905067650 cites W2121921343 @default.
- W2905067650 cites W2123974942 @default.
- W2905067650 cites W2124852816 @default.
- W2905067650 cites W2126402425 @default.
- W2905067650 cites W2129804244 @default.
- W2905067650 cites W2131041787 @default.
- W2905067650 cites W2134630622 @default.
- W2905067650 cites W2147515151 @default.
- W2905067650 cites W2149450071 @default.
- W2905067650 cites W2150472993 @default.
- W2905067650 cites W2163644328 @default.
- W2905067650 cites W2163772343 @default.
- W2905067650 cites W2164133449 @default.
- W2905067650 cites W2166595292 @default.
- W2905067650 cites W2166949480 @default.
- W2905067650 cites W2168334242 @default.
- W2905067650 cites W2179357850 @default.
- W2905067650 cites W2181705189 @default.
- W2905067650 cites W2205233891 @default.
- W2905067650 cites W2257889532 @default.
- W2905067650 cites W2263406196 @default.
- W2905067650 cites W2411915694 @default.
- W2905067650 cites W2460778061 @default.
- W2905067650 cites W2470343227 @default.
- W2905067650 cites W2556164933 @default.
- W2905067650 cites W2559266851 @default.
- W2905067650 cites W2593993808 @default.
- W2905067650 cites W2596326857 @default.
- W2905067650 cites W2723277039 @default.
- W2905067650 cites W2775434086 @default.
- W2905067650 cites W2806009800 @default.
- W2905067650 cites W2891385830 @default.