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- W2905079855 abstract "The first genome-wide association study of fulminant type 1 diabetes was performed in Japanese individuals. As previously reported using a candidate gene approach, a strong association was observed with multiple single nucleotide polymorphisms (SNPs) in the HLA region, and the strongest association was observed with rs9268853 in the class II DR region (P = 1.56 × 10−23, odds ratio [OR] 3.18). In addition, rs11170445 in CSAD/lnc-ITGB7-1 on chromosome 12q13.13 showed an association at a genome-wide significance level (P = 7.58 × 10−9, OR 1.96). Fine mapping of the region revealed that rs3782151 in CSAD/lnc-ITGB7-1 showed the lowest P value (P = 4.60 × 10−9, OR 1.97 [95% CI 1.57–2.48]). The risk allele of rs3782151 is a cis expression quantitative trait locus for ITGB7 that significantly increases the expression of this gene. CSAD/lnc-ITGB7-1 was found to be strongly associated with susceptibility to fulminant, but not classical, autoimmune type 1 diabetes, implicating this locus in the distinct phenotype of fulminant type 1 diabetes." @default.
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- W2905079855 date "2018-12-14" @default.
- W2905079855 modified "2023-10-15" @default.
- W2905079855 title "Genome-Wide Association Study Confirming a Strong Effect of HLA and Identifying Variants in <i>CSAD/lnc-ITGB7-1</i> on Chromosome 12q13.13 Associated With Susceptibility to Fulminant Type 1 Diabetes" @default.
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- W2905079855 doi "https://doi.org/10.2337/db18-0314" @default.
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