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- W2905137394 abstract "Abstract Advances in the treatment of melanoma, especially the development of immunomodulating monoclonal antibodies and small-molecule targeted therapies, have significantly improved the prognosis for patients. Monotherapy with many of these agents has been shown to significantly improve progression-free survival and overall survival beyond what was previously achieved with chemotherapy. However, even greater improvements have been gained through the use of various combination approaches. Combining immunotherapies that target distinct immune pathways has the potential to overcome the barriers that tumor cells use to evade the immune system and can provide a clinical benefit in more patients than achieved with single-agent treatment. In addition, combining immune-based approaches with other treatment modalities, such as chemotherapy, radiotherapy, or targeted agents, may offer a complementary effect. Doublet and even triplet combinations involving these new agents appear likely to become new gold standards of care, although questions regarding the most effective combination strategies remain." @default.
- W2905137394 created "2018-12-22" @default.
- W2905137394 creator A5029398339 @default.
- W2905137394 date "2019-01-01" @default.
- W2905137394 modified "2023-10-16" @default.
- W2905137394 title "Immunotherapies and Novel Combinations" @default.
- W2905137394 doi "https://doi.org/10.1016/b978-0-12-811785-9.00045-4" @default.
- W2905137394 hasPublicationYear "2019" @default.
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