FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905144511> ?p ?o ?g. }

• W2905144511 endingPage "e0007021" @default.
• W2905144511 startingPage "e0007021" @default.
• W2905144511 abstract "Nematode parasites cause substantial morbidity to billions of people and considerable losses in livestock and food crops. The repertoire of effective anthelmintic compounds for treating these parasitoses is very limited, as drug development has been delayed for decades. Moreover, resistance has become a global concern in livestock parasites and is an emerging issue for human helminthiasis. Therefore, anthelmintics with novel mechanisms of action are urgently needed. Taking advantage of Caenorhabditis elegans as an established model system, we here screened the nematicidal potential of novel imidazolium and imidazole derivatives. One of these derivatives, diisopropylphenyl-imidazole (DII), is lethal to C. elegans at both mature and immature stages. This lethal effect appears to be specific because DII concentrations which prove to be toxic to C. elegans do not induce significant lethality on bacteria, Drosophila melanogaster, and HEK-293 cells. Our analysis of DII action on C. elegans mutant strains determined that, in the adult stage, null mutants of unc-29 are resistant to the drug. Muscle expression of this gene completely restores DII sensitivity. UNC-29 has been largely reported as an essential constituent of the levamisole-sensitive muscle nicotinic receptor (L-AChR). Nevertheless, null mutants in unc-63 and lev-8 (essential and non-essential subunits of L-AChRs, respectively) are as sensitive to DII as the wild-type strain. Therefore, our results suggest that DII effects on adult nematodes rely on a previously unidentified UNC-29-containing muscle AChR, different from the classical L-AChR. Interestingly, DII targets appear to be different between larvae and adults, as unc-29 null mutant larvae are sensitive to the drug. The existence of more than one target could delay resistance development. Its lethality on C. elegans, its harmlessness in non-nematode species and its novel and dual mechanism of action make DII a promising candidate compound for anthelmintic therapy." @default.
• W2905144511 created "2018-12-22" @default.
• W2905144511 creator A5015494200 @default.
• W2905144511 creator A5025095704 @default.
• W2905144511 creator A5027195663 @default.
• W2905144511 creator A5030908095 @default.
• W2905144511 creator A5033684659 @default.
• W2905144511 creator A5039583790 @default.
• W2905144511 creator A5044492317 @default.
• W2905144511 date "2018-12-17" @default.
• W2905144511 modified "2023-10-09" @default.
• W2905144511 title "Diisopropylphenyl-imidazole (DII): A new compound that exerts anthelmintic activity through novel molecular mechanisms" @default.
• W2905144511 cites W1156765303 @default.
• W2905144511 cites W1571756799 @default.
• W2905144511 cites W1605667399 @default.
• W2905144511 cites W1790499166 @default.
• W2905144511 cites W1950248588 @default.
• W2905144511 cites W1954391111 @default.
• W2905144511 cites W1971083012 @default.
• W2905144511 cites W1971446667 @default.
• W2905144511 cites W1973869415 @default.
• W2905144511 cites W1973973036 @default.
• W2905144511 cites W1978433149 @default.
• W2905144511 cites W1983091058 @default.
• W2905144511 cites W1983766546 @default.
• W2905144511 cites W1988717791 @default.
• W2905144511 cites W1988751855 @default.
• W2905144511 cites W1990372039 @default.
• W2905144511 cites W1990907625 @default.
• W2905144511 cites W1991634478 @default.
• W2905144511 cites W1996736459 @default.
• W2905144511 cites W1997700668 @default.
• W2905144511 cites W2002673480 @default.
• W2905144511 cites W2019294804 @default.
• W2905144511 cites W2020300669 @default.
• W2905144511 cites W2021704559 @default.
• W2905144511 cites W2024473147 @default.
• W2905144511 cites W2026272710 @default.
• W2905144511 cites W2037645437 @default.
• W2905144511 cites W2037855135 @default.
• W2905144511 cites W2038638853 @default.
• W2905144511 cites W2047557706 @default.
• W2905144511 cites W2051941446 @default.
• W2905144511 cites W2055547557 @default.
• W2905144511 cites W2056059358 @default.
• W2905144511 cites W2063740108 @default.
• W2905144511 cites W2067517788 @default.
• W2905144511 cites W2068652493 @default.
• W2905144511 cites W2070788690 @default.
• W2905144511 cites W2089330719 @default.
• W2905144511 cites W2090560190 @default.
• W2905144511 cites W2090690189 @default.
• W2905144511 cites W2092489329 @default.
• W2905144511 cites W2094160044 @default.
• W2905144511 cites W2095784896 @default.
• W2905144511 cites W2100365580 @default.
• W2905144511 cites W2101058219 @default.
• W2905144511 cites W2111915171 @default.
• W2905144511 cites W2113130542 @default.
• W2905144511 cites W2115726385 @default.
• W2905144511 cites W2116394768 @default.
• W2905144511 cites W2119156856 @default.
• W2905144511 cites W2122288804 @default.
• W2905144511 cites W2123316581 @default.
• W2905144511 cites W2130233455 @default.
• W2905144511 cites W2131521454 @default.
• W2905144511 cites W2132930846 @default.
• W2905144511 cites W2144629860 @default.
• W2905144511 cites W2146263980 @default.
• W2905144511 cites W2148044601 @default.
• W2905144511 cites W2156687482 @default.
• W2905144511 cites W2157169202 @default.
• W2905144511 cites W2170595558 @default.
• W2905144511 cites W2210064796 @default.
• W2905144511 cites W2234292754 @default.
• W2905144511 cites W2262047600 @default.
• W2905144511 cites W2263236687 @default.
• W2905144511 cites W2312352689 @default.
• W2905144511 cites W2410767878 @default.
• W2905144511 cites W2536793719 @default.
• W2905144511 cites W2612453616 @default.
• W2905144511 cites W2767328427 @default.
• W2905144511 cites W2802093561 @default.
• W2905144511 cites W4234444023 @default.
• W2905144511 cites W4240005272 @default.
• W2905144511 doi "https://doi.org/10.1371/journal.pntd.0007021" @default.
• W2905144511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6312359" @default.
• W2905144511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30557347" @default.
• W2905144511 hasPublicationYear "2018" @default.
• W2905144511 type Work @default.
• W2905144511 sameAs 2905144511 @default.
• W2905144511 citedByCount "11" @default.
• W2905144511 countsByYear W29051445112019 @default.
• W2905144511 countsByYear W29051445112020 @default.
• W2905144511 countsByYear W29051445112021 @default.
• W2905144511 countsByYear W29051445112022 @default.
• W2905144511 countsByYear W29051445112023 @default.
• W2905144511 crossrefType "journal-article" @default.

• next