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- W2905171557 abstract "HFs strongly interact with adipocytes within dWAT, suggesting a strong physiological dependence on the content of immature and mature adipocytes in this layer. This content is regulated by the proliferation and differentiation of adipose precursors and preadipocytes, as well as by dedifferentiation of mature existing adipocytes leading to the production of adipocyte-derived preadipocytes. Long-range spatial interactions between HFs and dermal adipocytes involve the exchange of extracellular vesicles which are differentially released by precursors, preadipocytes, and mature adipocytes, and are likely to carry various proteomic fingerprints during different phases of the HF cycle, effectively modulating the transcriptome profile of the recipient HFs. Different exogenous factors, including light irradiation and some chemical agents, can affect immature and immature adipocytes, and are likely to modify the release of adipocyte-derived exosomes in dWAT, which can lead to aberrations of the HF cycle. Dermal adipocytes should be considered as a potential target both for the modulation of hair growth and for the removal of unwanted hair. Hair follicles (HFs) strongly interact with adipocytes within the dermal white adipose tissue (dWAT), suggesting a strong physiological dependence on the content of immature and mature adipocytes in this layer. This content is regulated by the proliferation and differentiation of adipocyte precursors, as well as by dedifferentiation of mature existing adipocytes. Spatially, long-range interactions between HFs and dWAT involve the exchange of extracellular vesicles which are differentially released by precursors, preadipocytes, and mature adipocytes. Different exogenous factors, including light irradiation, are likely to modify the release of adipocyte-derived exosomes in dWAT, which can lead to aberrations of the HF cycle. Consequently, dWAT should be considered as a potential target for the modulation of hair growth. Hair follicles (HFs) strongly interact with adipocytes within the dermal white adipose tissue (dWAT), suggesting a strong physiological dependence on the content of immature and mature adipocytes in this layer. This content is regulated by the proliferation and differentiation of adipocyte precursors, as well as by dedifferentiation of mature existing adipocytes. Spatially, long-range interactions between HFs and dWAT involve the exchange of extracellular vesicles which are differentially released by precursors, preadipocytes, and mature adipocytes. Different exogenous factors, including light irradiation, are likely to modify the release of adipocyte-derived exosomes in dWAT, which can lead to aberrations of the HF cycle. Consequently, dWAT should be considered as a potential target for the modulation of hair growth." @default.
- W2905171557 created "2018-12-22" @default.
- W2905171557 creator A5011654690 @default.
- W2905171557 creator A5014680330 @default.
- W2905171557 creator A5077747436 @default.
- W2905171557 date "2019-02-01" @default.
- W2905171557 modified "2023-10-16" @default.
- W2905171557 title "The Role of Immature and Mature Adipocytes in Hair Cycling" @default.
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- W2905171557 doi "https://doi.org/10.1016/j.tem.2018.11.004" @default.
- W2905171557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6348020" @default.
- W2905171557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30558832" @default.
- W2905171557 hasPublicationYear "2019" @default.
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