FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905173610> ?p ?o ?g. }

• W2905173610 abstract "Background: Acetaminophen (APAP) poisoning is the most common drug intoxication, which often leads to acute liver failure and necrosis of liver tissue following the use of its excessive amounts. Objectives: In this study, the effects of toxic and therapeutic doses of acetaminophen were assessed on miR-122 and miR-192 compared to aminotransferase (AST and ALT) and liver pathological lesions in rats at the first and third hours of injection. Methods: In this study, 32 male Sprague-Dawley rats were randomly selected and divided into eight groups (four groups for the first-hour and four groups for the third-hour injection). In the case groups, three groups after one hour and three groups after three hours of injecting with APAP doses (75, 150, and 300 mg/kg bw) intraperitoneally were sampled and killed. Changes in necropsy and macroscopic features of the rat liver were recorded after staining. The plasma levels of miR-122 and miR-192 were evaluated using the real-time PCR method and plasma levels of liver enzymes such as AST and ALT were measured by using an automated analyzer. Results: The histopathological examination at the dose of 150 mg/kg revealed mild hyperemia and edema in the portal areas, as well as mild infiltration of inflammatory cells. Centrilobular necrosis was mild at 300 mg/kg. ALT and AST activities were not significantly different between the case and control groups at the first hour, but they were significant between the groups receiving APAP for three hours. Moreover, the results of miRNA were significant at different times and doses (P < 0.05). Conclusions: Due to the ability to induce a protective system against acetaminophen toxicity, the plasma level of miR-122 and miR-192 activity at the early hours will be more helpful than measuring ALT and AST levels (P < 0.05)." @default.
• W2905173610 created "2018-12-22" @default.
• W2905173610 creator A5001317393 @default.
• W2905173610 creator A5011208061 @default.
• W2905173610 creator A5065312590 @default.
• W2905173610 creator A5076584021 @default.
• W2905173610 creator A5087383031 @default.
• W2905173610 date "2018-12-16" @default.
• W2905173610 modified "2023-09-26" @default.
• W2905173610 title "Circulating miR-122 and miR-192 as Specific and Sensitive Biomarkers for Drug-Induced Liver Injury with Acetaminophen in Rats" @default.
• W2905173610 cites W1463602523 @default.
• W2905173610 cites W1968156832 @default.
• W2905173610 cites W2000816385 @default.
• W2905173610 cites W2006499219 @default.
• W2905173610 cites W2007834955 @default.
• W2905173610 cites W2015383619 @default.
• W2905173610 cites W2026531690 @default.
• W2905173610 cites W2032923154 @default.
• W2905173610 cites W2047102263 @default.
• W2905173610 cites W2047718984 @default.
• W2905173610 cites W2065559768 @default.
• W2905173610 cites W2092332477 @default.
• W2905173610 cites W2093982770 @default.
• W2905173610 cites W2107277218 @default.
• W2905173610 cites W2111848990 @default.
• W2905173610 cites W2115093090 @default.
• W2905173610 cites W2119056808 @default.
• W2905173610 cites W2133279956 @default.
• W2905173610 cites W2134810594 @default.
• W2905173610 cites W2137638861 @default.
• W2905173610 cites W2143053936 @default.
• W2905173610 cites W2158294232 @default.
• W2905173610 cites W2162449257 @default.
• W2905173610 cites W2163169629 @default.
• W2905173610 cites W2352573083 @default.
• W2905173610 cites W2499449074 @default.
• W2905173610 cites W2566494025 @default.
• W2905173610 cites W2568906085 @default.
• W2905173610 doi "https://doi.org/10.5812/jjnpp.65678" @default.
• W2905173610 hasPublicationYear "2018" @default.
• W2905173610 type Work @default.
• W2905173610 sameAs 2905173610 @default.
• W2905173610 citedByCount "2" @default.
• W2905173610 countsByYear W29051736102022 @default.
• W2905173610 countsByYear W29051736102023 @default.
• W2905173610 crossrefType "journal-article" @default.
• W2905173610 hasAuthorship W2905173610A5001317393 @default.
• W2905173610 hasAuthorship W2905173610A5011208061 @default.
• W2905173610 hasAuthorship W2905173610A5065312590 @default.
• W2905173610 hasAuthorship W2905173610A5076584021 @default.
• W2905173610 hasAuthorship W2905173610A5087383031 @default.
• W2905173610 hasBestOaLocation W29051736101 @default.
• W2905173610 hasConcept C125473707 @default.
• W2905173610 hasConcept C126322002 @default.
• W2905173610 hasConcept C204232928 @default.
• W2905173610 hasConcept C207886595 @default.
• W2905173610 hasConcept C2776637226 @default.
• W2905173610 hasConcept C2778722691 @default.
• W2905173610 hasConcept C2779864607 @default.
• W2905173610 hasConcept C2779965577 @default.
• W2905173610 hasConcept C2780035454 @default.
• W2905173610 hasConcept C2780886150 @default.
• W2905173610 hasConcept C2992176824 @default.
• W2905173610 hasConcept C503630168 @default.
• W2905173610 hasConcept C71924100 @default.
• W2905173610 hasConcept C90924648 @default.
• W2905173610 hasConcept C98274493 @default.
• W2905173610 hasConceptScore W2905173610C125473707 @default.
• W2905173610 hasConceptScore W2905173610C126322002 @default.
• W2905173610 hasConceptScore W2905173610C204232928 @default.
• W2905173610 hasConceptScore W2905173610C207886595 @default.
• W2905173610 hasConceptScore W2905173610C2776637226 @default.
• W2905173610 hasConceptScore W2905173610C2778722691 @default.
• W2905173610 hasConceptScore W2905173610C2779864607 @default.
• W2905173610 hasConceptScore W2905173610C2779965577 @default.
• W2905173610 hasConceptScore W2905173610C2780035454 @default.
• W2905173610 hasConceptScore W2905173610C2780886150 @default.
• W2905173610 hasConceptScore W2905173610C2992176824 @default.
• W2905173610 hasConceptScore W2905173610C503630168 @default.
• W2905173610 hasConceptScore W2905173610C71924100 @default.
• W2905173610 hasConceptScore W2905173610C90924648 @default.
• W2905173610 hasConceptScore W2905173610C98274493 @default.
• W2905173610 hasIssue "In Press" @default.
• W2905173610 hasLocation W29051736101 @default.
• W2905173610 hasOpenAccess W2905173610 @default.
• W2905173610 hasPrimaryLocation W29051736101 @default.
• W2905173610 hasRelatedWork W1516271342 @default.
• W2905173610 hasRelatedWork W2417895049 @default.
• W2905173610 hasRelatedWork W2466001514 @default.
• W2905173610 hasRelatedWork W2905173610 @default.
• W2905173610 hasRelatedWork W2977813901 @default.
• W2905173610 hasRelatedWork W2985131883 @default.
• W2905173610 hasRelatedWork W3104081815 @default.
• W2905173610 hasRelatedWork W1878952209 @default.
• W2905173610 hasRelatedWork W2044231188 @default.
• W2905173610 hasRelatedWork W2992152811 @default.
• W2905173610 hasVolume "In Press" @default.
• W2905173610 isParatext "false" @default.
• W2905173610 isRetracted "false" @default.
• W2905173610 magId "2905173610" @default.

• next