Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905179255> ?p ?o ?g. }
- W2905179255 endingPage "33" @default.
- W2905179255 startingPage "22" @default.
- W2905179255 abstract "Neutrophils are the most abundant immune cell of the innate immune system and participate in essential immune functions. Heterogeneity within neutrophils has been documented, but it is difficult to distinguish if these are altered activation states of a single population or separate subpopulations of neutrophils determined at the time of differentiation. Several groups have identified a subset of human neutrophils that express olfactomedin 4 (OLFM4) and increased OLFM4+ neutrophils during sepsis is correlated with worse outcome, suggesting these neutrophils or the OLFM4 they secrete may be pathogenic. We tested if mice could be used as a model to study OLFM4+ neutrophils. We found the OLFM4 expressing subset of neutrophils is conserved in mice. Depending on the strain, 7–35% of murine neutrophils express OLFM4 and expression is determined early in neutrophil differentiation. OLFM4+ neutrophils phagocytose and transmigrate with similar efficiency as OLFM4− neutrophils. Here we show that within neutrophil extracellular traps (NETs) OLFM4+ and OLFM4− neutrophils undergo NETosis and OLFM4 colocalizes. Finally, we generated an OLFM4 null mouse and show that these mice are protected from death when challenged with sepsis, providing further evidence that the OLFM4 expressing subpopulation of neutrophils, or the OLFM4 they secrete, may be pathogenic during overwhelming infection." @default.
- W2905179255 created "2018-12-22" @default.
- W2905179255 creator A5007396226 @default.
- W2905179255 creator A5020609229 @default.
- W2905179255 creator A5033756432 @default.
- W2905179255 creator A5072019431 @default.
- W2905179255 creator A5080427926 @default.
- W2905179255 creator A5082112042 @default.
- W2905179255 date "2018-12-11" @default.
- W2905179255 modified "2023-10-17" @default.
- W2905179255 title "Olfactomedin 4 marks a subset of neutrophils in mice" @default.
- W2905179255 cites W1670524885 @default.
- W2905179255 cites W1858198717 @default.
- W2905179255 cites W1967680980 @default.
- W2905179255 cites W1968833346 @default.
- W2905179255 cites W1975202537 @default.
- W2905179255 cites W1978232052 @default.
- W2905179255 cites W2003224865 @default.
- W2905179255 cites W2004638361 @default.
- W2905179255 cites W2005819448 @default.
- W2905179255 cites W2007767114 @default.
- W2905179255 cites W2018623897 @default.
- W2905179255 cites W2032227357 @default.
- W2905179255 cites W2037245332 @default.
- W2905179255 cites W2048418583 @default.
- W2905179255 cites W2054469201 @default.
- W2905179255 cites W2067525322 @default.
- W2905179255 cites W2071117491 @default.
- W2905179255 cites W2073274892 @default.
- W2905179255 cites W2089385363 @default.
- W2905179255 cites W2091648834 @default.
- W2905179255 cites W2103385495 @default.
- W2905179255 cites W2104779801 @default.
- W2905179255 cites W2110299641 @default.
- W2905179255 cites W2112671019 @default.
- W2905179255 cites W2128002321 @default.
- W2905179255 cites W2133875700 @default.
- W2905179255 cites W2136108844 @default.
- W2905179255 cites W2153357533 @default.
- W2905179255 cites W2170039745 @default.
- W2905179255 cites W2298930097 @default.
- W2905179255 cites W2396609580 @default.
- W2905179255 cites W2396645088 @default.
- W2905179255 cites W2520671596 @default.
- W2905179255 cites W2767911632 @default.
- W2905179255 cites W2810708767 @default.
- W2905179255 doi "https://doi.org/10.1177/1753425918817611" @default.
- W2905179255 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6661892" @default.
- W2905179255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30537894" @default.
- W2905179255 hasPublicationYear "2018" @default.
- W2905179255 type Work @default.
- W2905179255 sameAs 2905179255 @default.
- W2905179255 citedByCount "27" @default.
- W2905179255 countsByYear W29051792552019 @default.
- W2905179255 countsByYear W29051792552020 @default.
- W2905179255 countsByYear W29051792552021 @default.
- W2905179255 countsByYear W29051792552022 @default.
- W2905179255 countsByYear W29051792552023 @default.
- W2905179255 crossrefType "journal-article" @default.
- W2905179255 hasAuthorship W2905179255A5007396226 @default.
- W2905179255 hasAuthorship W2905179255A5020609229 @default.
- W2905179255 hasAuthorship W2905179255A5033756432 @default.
- W2905179255 hasAuthorship W2905179255A5072019431 @default.
- W2905179255 hasAuthorship W2905179255A5080427926 @default.
- W2905179255 hasAuthorship W2905179255A5082112042 @default.
- W2905179255 hasBestOaLocation W29051792551 @default.
- W2905179255 hasConcept C104317684 @default.
- W2905179255 hasConcept C127716648 @default.
- W2905179255 hasConcept C134018914 @default.
- W2905179255 hasConcept C134897094 @default.
- W2905179255 hasConcept C136449434 @default.
- W2905179255 hasConcept C203014093 @default.
- W2905179255 hasConcept C2776914184 @default.
- W2905179255 hasConcept C2779282312 @default.
- W2905179255 hasConcept C2908647359 @default.
- W2905179255 hasConcept C49039625 @default.
- W2905179255 hasConcept C54355233 @default.
- W2905179255 hasConcept C71924100 @default.
- W2905179255 hasConcept C86803240 @default.
- W2905179255 hasConcept C8891405 @default.
- W2905179255 hasConcept C89423630 @default.
- W2905179255 hasConcept C95444343 @default.
- W2905179255 hasConcept C99454951 @default.
- W2905179255 hasConceptScore W2905179255C104317684 @default.
- W2905179255 hasConceptScore W2905179255C127716648 @default.
- W2905179255 hasConceptScore W2905179255C134018914 @default.
- W2905179255 hasConceptScore W2905179255C134897094 @default.
- W2905179255 hasConceptScore W2905179255C136449434 @default.
- W2905179255 hasConceptScore W2905179255C203014093 @default.
- W2905179255 hasConceptScore W2905179255C2776914184 @default.
- W2905179255 hasConceptScore W2905179255C2779282312 @default.
- W2905179255 hasConceptScore W2905179255C2908647359 @default.
- W2905179255 hasConceptScore W2905179255C49039625 @default.
- W2905179255 hasConceptScore W2905179255C54355233 @default.
- W2905179255 hasConceptScore W2905179255C71924100 @default.
- W2905179255 hasConceptScore W2905179255C86803240 @default.
- W2905179255 hasConceptScore W2905179255C8891405 @default.
- W2905179255 hasConceptScore W2905179255C89423630 @default.