Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905202279> ?p ?o ?g. }
- W2905202279 endingPage "245" @default.
- W2905202279 startingPage "230" @default.
- W2905202279 abstract "The compression of brain tissue by a tumour mass is believed to be a major cause of the clinical symptoms seen in patients with brain cancer. However, the biological consequences of these physical stresses on brain tissue are unknown. Here, via imaging studies in patients and by using mouse models of human brain tumours, we show that a subgroup of primary and metastatic brain tumours, classified as nodular on the basis of their growth pattern, exert solid stress on the surrounding brain tissue, causing a decrease in local vascular perfusion as well as neuronal death and impaired function. We demonstrate a causal link between solid stress and neurological dysfunction by applying and removing cerebral compression, which respectively mimic the mechanics of tumour growth and of surgical resection. We also show that, in mice, treatment with lithium reduces solid-stress-induced neuronal death and improves motor coordination. Our findings indicate that brain-tumour-generated solid stress impairs neurological function in patients, and that lithium as a therapeutic intervention could counter these effects." @default.
- W2905202279 created "2018-12-22" @default.
- W2905202279 creator A5000603446 @default.
- W2905202279 creator A5003974495 @default.
- W2905202279 creator A5004819031 @default.
- W2905202279 creator A5007779722 @default.
- W2905202279 creator A5010584176 @default.
- W2905202279 creator A5013238098 @default.
- W2905202279 creator A5015585176 @default.
- W2905202279 creator A5015735736 @default.
- W2905202279 creator A5017936529 @default.
- W2905202279 creator A5020173185 @default.
- W2905202279 creator A5021656597 @default.
- W2905202279 creator A5021812533 @default.
- W2905202279 creator A5021963513 @default.
- W2905202279 creator A5033792599 @default.
- W2905202279 creator A5044970408 @default.
- W2905202279 creator A5049174232 @default.
- W2905202279 creator A5049677254 @default.
- W2905202279 creator A5054965207 @default.
- W2905202279 creator A5059200813 @default.
- W2905202279 creator A5065827707 @default.
- W2905202279 creator A5069527451 @default.
- W2905202279 creator A5077600835 @default.
- W2905202279 creator A5082835319 @default.
- W2905202279 creator A5084140964 @default.
- W2905202279 date "2019-01-07" @default.
- W2905202279 modified "2023-10-18" @default.
- W2905202279 title "Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium" @default.
- W2905202279 cites W1559213768 @default.
- W2905202279 cites W1947046122 @default.
- W2905202279 cites W1965545860 @default.
- W2905202279 cites W1967315867 @default.
- W2905202279 cites W1971712976 @default.
- W2905202279 cites W1972135632 @default.
- W2905202279 cites W1973638200 @default.
- W2905202279 cites W1979533444 @default.
- W2905202279 cites W1982151355 @default.
- W2905202279 cites W1983293427 @default.
- W2905202279 cites W1990488312 @default.
- W2905202279 cites W1992560794 @default.
- W2905202279 cites W1994681610 @default.
- W2905202279 cites W1995217653 @default.
- W2905202279 cites W1995297365 @default.
- W2905202279 cites W1998266575 @default.
- W2905202279 cites W2002729523 @default.
- W2905202279 cites W2008368065 @default.
- W2905202279 cites W2010086378 @default.
- W2905202279 cites W2019304821 @default.
- W2905202279 cites W2020311418 @default.
- W2905202279 cites W2032187521 @default.
- W2905202279 cites W2032308987 @default.
- W2905202279 cites W2033878276 @default.
- W2905202279 cites W2036306429 @default.
- W2905202279 cites W2037279622 @default.
- W2905202279 cites W2039162483 @default.
- W2905202279 cites W2040481122 @default.
- W2905202279 cites W2043892505 @default.
- W2905202279 cites W2043967411 @default.
- W2905202279 cites W2048788553 @default.
- W2905202279 cites W2051761181 @default.
- W2905202279 cites W2053766206 @default.
- W2905202279 cites W2058528191 @default.
- W2905202279 cites W2060867475 @default.
- W2905202279 cites W2069247119 @default.
- W2905202279 cites W2069284781 @default.
- W2905202279 cites W2087764724 @default.
- W2905202279 cites W2089132813 @default.
- W2905202279 cites W2092757943 @default.
- W2905202279 cites W2096487280 @default.
- W2905202279 cites W2098249941 @default.
- W2905202279 cites W2099102582 @default.
- W2905202279 cites W2099164578 @default.
- W2905202279 cites W2108956608 @default.
- W2905202279 cites W2109604886 @default.
- W2905202279 cites W2110865978 @default.
- W2905202279 cites W2123369892 @default.
- W2905202279 cites W2126531317 @default.
- W2905202279 cites W2127830951 @default.
- W2905202279 cites W2131478115 @default.
- W2905202279 cites W2132094327 @default.
- W2905202279 cites W2137816700 @default.
- W2905202279 cites W2139158372 @default.
- W2905202279 cites W2142399962 @default.
- W2905202279 cites W2147684729 @default.
- W2905202279 cites W2158217645 @default.
- W2905202279 cites W2169456326 @default.
- W2905202279 cites W2171157655 @default.
- W2905202279 cites W2175465835 @default.
- W2905202279 cites W2326749252 @default.
- W2905202279 cites W2328171087 @default.
- W2905202279 cites W2374911498 @default.
- W2905202279 cites W2486492325 @default.
- W2905202279 cites W2513294073 @default.
- W2905202279 cites W2545856467 @default.
- W2905202279 cites W2552728987 @default.
- W2905202279 cites W2598652703 @default.
- W2905202279 cites W2612880358 @default.