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- W2905204865 abstract "MicroRNAs (miRNAs) are short non-coding RNAs that are involved in the post-transcriptional regulation of protein-coding genes. miRNAs modulate lifespan and the aging process in a variety of organisms. In this study, we identified a role of miR-83 in regulating lifespan of Caenorhabditis elegans. mir-83 mutants exhibited extended lifespan, and the overexpression of miR-83 was sufficient to decrease the prolonged lifespan of the mutants. We observed upregulation of the expression levels of a set of miR-83 target genes in young mir-83 mutant adults; while different sets of genes were upregulated in older mir-83 mutant adults. In vivo assays showed that miR-83 regulated expression of target genes including din-1, spp-9 and col-178, and we demonstrated that daf-16 and din-1 were required for the extension of lifespan in the mir-83 mutants. The regulation of din-1 by miR-83 during aging resulted in the differential expression of din-1 targets such as gst-4 and gst-10. In daf-2 mutants, the expression level of miR-83 was significantly reduced compared to wild-type animals. We identified a role for miR-83 in modulating lifespan in C. elegans and provided molecular insights into its functional mechanism." @default.
- W2905204865 created "2018-12-22" @default.
- W2905204865 creator A5003092267 @default.
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- W2905204865 date "2018-12-01" @default.
- W2905204865 modified "2023-10-09" @default.
- W2905204865 title "Loss of miR-83 extends lifespan and affects target gene expression in an age-dependent manner in Caenorhabditis elegans" @default.
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- W2905204865 cites W1970254099 @default.
- W2905204865 cites W1971578941 @default.
- W2905204865 cites W1979369962 @default.
- W2905204865 cites W1985964755 @default.
- W2905204865 cites W1987824810 @default.
- W2905204865 cites W1989313716 @default.
- W2905204865 cites W2003952411 @default.
- W2905204865 cites W2005185175 @default.
- W2905204865 cites W2007198184 @default.
- W2905204865 cites W2010461414 @default.
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- W2905204865 cites W2102840368 @default.
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- W2905204865 cites W2171398108 @default.
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- W2905204865 cites W2210476349 @default.
- W2905204865 cites W2254058053 @default.
- W2905204865 cites W2278032270 @default.
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- W2905204865 doi "https://doi.org/10.1016/j.jgg.2018.11.003" @default.
- W2905204865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30595472" @default.
- W2905204865 hasPublicationYear "2018" @default.
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