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- W2905217756 startingPage "227" @default.
- W2905217756 abstract "Cell-based technologies are used as a therapeutic strategy in spinal cord injury (SCI). Mesenchymal stem cells (MSCs), which secrete various neurotrophic factors and cytokines, have immunomodulatory, anti-apoptotic and anti-inflammatory effects, modulate reactivity/phenotype of astrocytes and the microglia, thereby promoting neuroregeneration seem to be the most promising. The therapeutic effect of MSCs is due to a paracrine mechanism of their action, therefore the survival of MSCs and their secretory phenotype is of particular importance. Nevertheless, these data are not always reported in efficacy studies of MSC therapy in SCI. Here, we provide a review with summaries of preclinical trials data evaluating the efficacy of MSCs in animal models of SCI. Based on the data collected, we have tried (1) to establish the behavior of MSCs after transplantation in SCI with an evaluation of cell survival, migration potential, distribution in the area of injured and intact tissue and possible differentiation; (2) to determine the effects MSCs on neuronal microenvironment and correlate them with the efficacy of functional recovery in SCI; (3) to ascertain the conditions under which MSCs demonstrate their best survival and greatest efficacy." @default.
- W2905217756 created "2018-12-22" @default.
- W2905217756 creator A5010896657 @default.
- W2905217756 creator A5044743031 @default.
- W2905217756 creator A5050393626 @default.
- W2905217756 creator A5066414193 @default.
- W2905217756 creator A5075568571 @default.
- W2905217756 date "2019-01-01" @default.
- W2905217756 modified "2023-10-18" @default.
- W2905217756 title "Mesenchymal stem cells and the neuronal microenvironment in the area of spinal cord injury" @default.
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