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• W2905230118 endingPage "e12459" @default.
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• W2905230118 abstract "Bariatric surgery, especially Roux-en-Y gastric bypass (RYGB), is the best treatment for severe obesity and its complications including type 2 diabetes mellitus (T2DM). Understanding the mechanisms responsible for the beneficial metabolic effects will help to engineer ways to improve the procedure or produce these effects without surgery.The aim is to present data on recruitment and feasibility of a translational study designed to collect intestinal samples before and after bariatric surgery. The goal of biobanking is to allow future studies to test the hypothesis that the mechanism of action of RYGB involves specific changes in the postsurgical short- and long-term metabolism and morphology of the jejunum (Roux limb). Specifically, to test whether the intestine enhances its metabolism and activity after RYGB and increases its fuel utilization, we designed a prospective, longitudinal study, which involved the recruitment of candidates for RYGB with and without T2DM. We describe the tissue bank that we have generated, and our experience, hoping to further facilitate the performance of longitudinal mechanistic studies in human patients undergoing bariatric surgery and especially those involving post-RYGB intestinal biology.We conducted a trial to characterize the effects of RYGB on intestinal metabolism. Intestinal tissue samples were collected from the jejunum at surgery, 1, 6, and 12 months postoperatively for the analysis of intestinal gene expression and metabolomic and morphologic changes. The target number of patients who completed at least the 6-month follow-up was 26, and we included a 20% attrition rate, increasing the total number to 32.To enroll 26 patients, we had to approach 79 potential participants. A total of 37 agreed to participate and started the study; 33, 30, and 26 active participants completed their 1-month, 6-month, and 12-month studies, respectively. Three participants withdrew, and 30 participants are still active. Altruism and interest in research were the most common reasons for participation. Important factors for feasibility and successful retention included (1) large volume case flow, (2) inclusion and exclusion criteria broad enough to capture a large segment of the patient population but narrow enough to ensure the completion of study aims and protection of safety concerns, (3) accurate assessment of willingness and motivation to participate in a study, (4) seamless integration of the recruitment process into normal clinical flow, (5) financial reimbursement and nonfinancial rewards and gestures of appreciation, and (6) nonburdensome follow-up visits and measures and reasonable time allotted.Human translational studies of the intestinal mechanisms of metabolic and weight changes after bariatric surgery are important and feasible. A tissue bank with unique samples has been established that could be used by investigators in many research fields, further enabling mechanistic studies on the effects of bariatric surgery.ClinicalTrials.gov NCT02710370; https://clinicaltrials.gov/ct2/show/NCT02710370 (Archived by WebCite at http://www.webcitation.org/75HrQT8Dl)." @default.
• W2905230118 created "2018-12-22" @default.
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• W2905230118 creator A5071083314 @default.
• W2905230118 date "2019-01-24" @default.
• W2905230118 modified "2023-10-14" @default.
• W2905230118 title "The Feasibility of Examining the Effects of Gastric Bypass Surgery on Intestinal Metabolism: Prospective, Longitudinal Mechanistic Clinical Trial" @default.
• W2905230118 cites W1031271816 @default.
• W2905230118 cites W1460247339 @default.
• W2905230118 cites W1558000543 @default.
• W2905230118 cites W1586811921 @default.
• W2905230118 cites W1596515083 @default.
• W2905230118 cites W1853555570 @default.
• W2905230118 cites W1904245801 @default.
• W2905230118 cites W1967206613 @default.
• W2905230118 cites W1970933249 @default.
• W2905230118 cites W1975801154 @default.
• W2905230118 cites W1977446402 @default.
• W2905230118 cites W1978153736 @default.
• W2905230118 cites W1978501365 @default.
• W2905230118 cites W1981663046 @default.
• W2905230118 cites W1982680385 @default.
• W2905230118 cites W1990351625 @default.
• W2905230118 cites W1990514678 @default.
• W2905230118 cites W1994227607 @default.
• W2905230118 cites W2011207494 @default.
• W2905230118 cites W2016648958 @default.
• W2905230118 cites W2028490901 @default.
• W2905230118 cites W2028913390 @default.
• W2905230118 cites W2029903631 @default.
• W2905230118 cites W2035310184 @default.
• W2905230118 cites W2043001041 @default.
• W2905230118 cites W2049104465 @default.
• W2905230118 cites W2054356692 @default.
• W2905230118 cites W2057900926 @default.
• W2905230118 cites W2067021370 @default.
• W2905230118 cites W2079146981 @default.
• W2905230118 cites W2079801652 @default.
• W2905230118 cites W2085908632 @default.
• W2905230118 cites W2099215299 @default.
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• W2905230118 cites W2111140583 @default.
• W2905230118 cites W2119015994 @default.
• W2905230118 cites W2122631753 @default.
• W2905230118 cites W2122783437 @default.
• W2905230118 cites W2124482977 @default.
• W2905230118 cites W2137554096 @default.
• W2905230118 cites W2145729618 @default.
• W2905230118 cites W2149011023 @default.
• W2905230118 cites W2150028354 @default.
• W2905230118 cites W2151538189 @default.
• W2905230118 cites W2155185912 @default.
• W2905230118 cites W2155186909 @default.
• W2905230118 cites W2159736110 @default.
• W2905230118 cites W2159741108 @default.
• W2905230118 cites W2181611453 @default.
• W2905230118 cites W2297046696 @default.
• W2905230118 cites W2314013953 @default.
• W2905230118 cites W2391113567 @default.
• W2905230118 cites W2397499320 @default.
• W2905230118 cites W2551650271 @default.
• W2905230118 cites W2588239899 @default.
• W2905230118 cites W2612355004 @default.
• W2905230118 cites W2612630529 @default.
• W2905230118 cites W2619504127 @default.
• W2905230118 cites W2733091225 @default.
• W2905230118 cites W2752972866 @default.
• W2905230118 cites W2755857027 @default.
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• W2905230118 doi "https://doi.org/10.2196/12459" @default.
• W2905230118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6483060" @default.
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• W2905230118 hasPublicationYear "2019" @default.
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