Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905243092> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2905243092 endingPage "142" @default.
- W2905243092 startingPage "139" @default.
- W2905243092 abstract "The ever-increasing occurrence of antibiotic resistance presents a major threat to public health. Specifically, resistance conferred by β-lactamases places the efficacy of currently available antibiotics at risk. Klebsiella pneumoniae carbapenemase-2 (KPC-2) is a β-lactamase that enables carbapenem resistance and represents a clear and present danger to global public health. In order to combat bacterial infections harboring KPC-2 expression, inhibitors with improved potency need to be developed. Although the structure of KPC-2 has been solved by X-ray crystallography, NMR provides the unique opportunity to study the structure and dynamics of flexible loop regions in solution. Here we report the 1H, 13C, and 15N backbone chemical shift assignments for KPC-2 in the apo state as the first step towards the study of KPC-2 dynamics in the presence and absence of ligands to enable the rational design of optimized inhibitors." @default.
- W2905243092 created "2018-12-22" @default.
- W2905243092 creator A5000611736 @default.
- W2905243092 creator A5013027842 @default.
- W2905243092 creator A5027428071 @default.
- W2905243092 creator A5073785555 @default.
- W2905243092 creator A5080155482 @default.
- W2905243092 date "2018-12-14" @default.
- W2905243092 modified "2023-10-17" @default.
- W2905243092 title "1H, 13C, and 15N backbone resonance assignments for KPC-2, a class A serine-β-lactamase" @default.
- W2905243092 cites W1518311090 @default.
- W2905243092 cites W1601568241 @default.
- W2905243092 cites W1768032859 @default.
- W2905243092 cites W1990241868 @default.
- W2905243092 cites W2045211463 @default.
- W2905243092 cites W2056076326 @default.
- W2905243092 cites W2079342481 @default.
- W2905243092 cites W2081183202 @default.
- W2905243092 cites W2091219913 @default.
- W2905243092 cites W2103171109 @default.
- W2905243092 cites W2107599341 @default.
- W2905243092 cites W2112418305 @default.
- W2905243092 cites W2136332525 @default.
- W2905243092 cites W2145111808 @default.
- W2905243092 cites W2168322413 @default.
- W2905243092 cites W2169821755 @default.
- W2905243092 cites W2763322245 @default.
- W2905243092 cites W2766376787 @default.
- W2905243092 doi "https://doi.org/10.1007/s12104-018-9866-8" @default.
- W2905243092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6440833" @default.
- W2905243092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30552637" @default.
- W2905243092 hasPublicationYear "2018" @default.
- W2905243092 type Work @default.
- W2905243092 sameAs 2905243092 @default.
- W2905243092 citedByCount "2" @default.
- W2905243092 countsByYear W29052430922022 @default.
- W2905243092 crossrefType "journal-article" @default.
- W2905243092 hasAuthorship W2905243092A5000611736 @default.
- W2905243092 hasAuthorship W2905243092A5013027842 @default.
- W2905243092 hasAuthorship W2905243092A5027428071 @default.
- W2905243092 hasAuthorship W2905243092A5073785555 @default.
- W2905243092 hasAuthorship W2905243092A5080155482 @default.
- W2905243092 hasBestOaLocation W29052430922 @default.
- W2905243092 hasConcept C109214941 @default.
- W2905243092 hasConcept C111472728 @default.
- W2905243092 hasConcept C121332964 @default.
- W2905243092 hasConcept C138885662 @default.
- W2905243092 hasConcept C139210041 @default.
- W2905243092 hasConcept C181199279 @default.
- W2905243092 hasConcept C185592680 @default.
- W2905243092 hasConcept C2776414213 @default.
- W2905243092 hasConcept C2777212361 @default.
- W2905243092 hasConcept C46141821 @default.
- W2905243092 hasConcept C55493867 @default.
- W2905243092 hasConcept C71240020 @default.
- W2905243092 hasConcept C86803240 @default.
- W2905243092 hasConceptScore W2905243092C109214941 @default.
- W2905243092 hasConceptScore W2905243092C111472728 @default.
- W2905243092 hasConceptScore W2905243092C121332964 @default.
- W2905243092 hasConceptScore W2905243092C138885662 @default.
- W2905243092 hasConceptScore W2905243092C139210041 @default.
- W2905243092 hasConceptScore W2905243092C181199279 @default.
- W2905243092 hasConceptScore W2905243092C185592680 @default.
- W2905243092 hasConceptScore W2905243092C2776414213 @default.
- W2905243092 hasConceptScore W2905243092C2777212361 @default.
- W2905243092 hasConceptScore W2905243092C46141821 @default.
- W2905243092 hasConceptScore W2905243092C55493867 @default.
- W2905243092 hasConceptScore W2905243092C71240020 @default.
- W2905243092 hasConceptScore W2905243092C86803240 @default.
- W2905243092 hasFunder F4320337354 @default.
- W2905243092 hasFunder F4320337355 @default.
- W2905243092 hasIssue "1" @default.
- W2905243092 hasLocation W29052430921 @default.
- W2905243092 hasLocation W29052430922 @default.
- W2905243092 hasLocation W29052430923 @default.
- W2905243092 hasOpenAccess W2905243092 @default.
- W2905243092 hasPrimaryLocation W29052430921 @default.
- W2905243092 hasRelatedWork W1523357361 @default.
- W2905243092 hasRelatedWork W1559155672 @default.
- W2905243092 hasRelatedWork W175432153 @default.
- W2905243092 hasRelatedWork W1763075096 @default.
- W2905243092 hasRelatedWork W1971404345 @default.
- W2905243092 hasRelatedWork W1996140555 @default.
- W2905243092 hasRelatedWork W2078685491 @default.
- W2905243092 hasRelatedWork W2085061074 @default.
- W2905243092 hasRelatedWork W2317133300 @default.
- W2905243092 hasRelatedWork W2950917999 @default.
- W2905243092 hasVolume "13" @default.
- W2905243092 isParatext "false" @default.
- W2905243092 isRetracted "false" @default.
- W2905243092 magId "2905243092" @default.
- W2905243092 workType "article" @default.