FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905249489> ?p ?o ?g. }

• W2905249489 abstract "NFATc4, a member from the Nuclear Factor of Activated T cells (NFATs) transcription factor family, plays a pivotal role in the development of cardiac hypertrophy. NFATc4 is dephosphorylated by calcineurin and translocated from the cytoplasm to the nucleus to regulate the expression of hypertrophic genes, like brain natriuretic polypeptide (BNP). The present study identified SIRT6, an important subtype of NAD+ dependent class Ⅲ histone deacetylase, to be a negative regulator of NFATc4 in cardiomyocyte hypertrophy. In phenylephrine (PE)-induced hypertrophic cardiomyocyte model, overexpression of SIRT6 by adenovirus infection or by plasmid transfection repressed the protein and mRNA expressions of NFATc4, elevated its phosphorylation level, prevented its nuclear accumulation, subsequently suppressed its transcriptional activity and downregulated its target gene BNP. By contrast, mutant of SIRT6 without deacetylase activity (H133Y) did not demonstrate these effects, suggesting that the inhibitory effect of SIRT6 on NFATc4 was dependent on its deacetylase activity. Moreover, the effect of SIRT6 overexpression on repressing BNP expression was reversed by NFATc4 replenishment, whereas the effect of SIRT6 deficiency on upregulating BNP was recovered by NFATc4 silencing. Mechanistically, interactions between SIRT6 and NFATc4 might possibly facilitate the deacetylation of NFATc4 by SIRT6, thereby preventing the activation of NFATc4. In conclusion, the present study reveals that SIRT6 suppresses the expression and activation of NFATc4. These findings provide more evidences of the anti-hypertrophic effect of SIRT6, and suggest SIRT6 as a potential therapeutic target for cardiac hypertrophy." @default.
• W2905249489 created "2018-12-22" @default.
• W2905249489 creator A5009067006 @default.
• W2905249489 creator A5024396177 @default.
• W2905249489 creator A5026035950 @default.
• W2905249489 creator A5038096051 @default.
• W2905249489 creator A5072198685 @default.
• W2905249489 creator A5081635779 @default.
• W2905249489 creator A5082213642 @default.
• W2905249489 date "2019-01-08" @default.
• W2905249489 modified "2023-10-18" @default.
• W2905249489 title "SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy" @default.
• W2905249489 cites W1160695953 @default.
• W2905249489 cites W1579391006 @default.
• W2905249489 cites W1965861063 @default.
• W2905249489 cites W1967222563 @default.
• W2905249489 cites W2011008275 @default.
• W2905249489 cites W2026355845 @default.
• W2905249489 cites W2036145275 @default.
• W2905249489 cites W2036272929 @default.
• W2905249489 cites W2041043528 @default.
• W2905249489 cites W2052102610 @default.
• W2905249489 cites W2053010478 @default.
• W2905249489 cites W2082502466 @default.
• W2905249489 cites W2090536285 @default.
• W2905249489 cites W2091592969 @default.
• W2905249489 cites W2115574360 @default.
• W2905249489 cites W2127177109 @default.
• W2905249489 cites W2152702315 @default.
• W2905249489 cites W2156433522 @default.
• W2905249489 cites W2160634299 @default.
• W2905249489 cites W2167711201 @default.
• W2905249489 cites W2232392866 @default.
• W2905249489 cites W2258710488 @default.
• W2905249489 cites W2294575394 @default.
• W2905249489 cites W2296363345 @default.
• W2905249489 cites W2299192455 @default.
• W2905249489 cites W2320849732 @default.
• W2905249489 cites W2322255069 @default.
• W2905249489 cites W2343024784 @default.
• W2905249489 cites W2346235897 @default.
• W2905249489 cites W2346765989 @default.
• W2905249489 cites W2374078013 @default.
• W2905249489 cites W2537397924 @default.
• W2905249489 cites W2548287959 @default.
• W2905249489 cites W2552184863 @default.
• W2905249489 cites W2562099827 @default.
• W2905249489 cites W2591922279 @default.
• W2905249489 cites W2604756658 @default.
• W2905249489 cites W2735527371 @default.
• W2905249489 cites W2748577840 @default.
• W2905249489 cites W2767757592 @default.
• W2905249489 cites W2774700072 @default.
• W2905249489 cites W2774778331 @default.
• W2905249489 cites W2774968355 @default.
• W2905249489 cites W2783574454 @default.
• W2905249489 cites W2784152123 @default.
• W2905249489 cites W2788055756 @default.
• W2905249489 cites W2794091867 @default.
• W2905249489 cites W2801050754 @default.
• W2905249489 cites W2936133655 @default.
• W2905249489 cites W601488828 @default.
• W2905249489 doi "https://doi.org/10.3389/fphar.2018.01519" @default.
• W2905249489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6331469" @default.
• W2905249489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30670969" @default.
• W2905249489 hasPublicationYear "2019" @default.
• W2905249489 type Work @default.
• W2905249489 sameAs 2905249489 @default.
• W2905249489 citedByCount "22" @default.
• W2905249489 countsByYear W29052494892020 @default.
• W2905249489 countsByYear W29052494892021 @default.
• W2905249489 countsByYear W29052494892022 @default.
• W2905249489 countsByYear W29052494892023 @default.
• W2905249489 crossrefType "journal-article" @default.
• W2905249489 hasAuthorship W2905249489A5009067006 @default.
• W2905249489 hasAuthorship W2905249489A5024396177 @default.
• W2905249489 hasAuthorship W2905249489A5026035950 @default.
• W2905249489 hasAuthorship W2905249489A5038096051 @default.
• W2905249489 hasAuthorship W2905249489A5072198685 @default.
• W2905249489 hasAuthorship W2905249489A5081635779 @default.
• W2905249489 hasAuthorship W2905249489A5082213642 @default.
• W2905249489 hasBestOaLocation W29052494891 @default.
• W2905249489 hasConcept C104317684 @default.
• W2905249489 hasConcept C119056186 @default.
• W2905249489 hasConcept C119157956 @default.
• W2905249489 hasConcept C185592680 @default.
• W2905249489 hasConcept C2777595374 @default.
• W2905249489 hasConcept C2778305200 @default.
• W2905249489 hasConcept C2780561631 @default.
• W2905249489 hasConcept C502942594 @default.
• W2905249489 hasConcept C54009773 @default.
• W2905249489 hasConcept C55493867 @default.
• W2905249489 hasConcept C64927066 @default.
• W2905249489 hasConcept C86339819 @default.
• W2905249489 hasConcept C86803240 @default.
• W2905249489 hasConcept C95444343 @default.
• W2905249489 hasConceptScore W2905249489C104317684 @default.
• W2905249489 hasConceptScore W2905249489C119056186 @default.
• W2905249489 hasConceptScore W2905249489C119157956 @default.
• W2905249489 hasConceptScore W2905249489C185592680 @default.

• next