Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905256920> ?p ?o ?g. }
- W2905256920 endingPage "176" @default.
- W2905256920 startingPage "158" @default.
- W2905256920 abstract "Passive administration of broadly neutralizing anti-human immunodeficiency virus type 1 (HIV-1) antibodies (bNAbs) has been recently suggested as a promising alternative therapeutic approach for HIV-1 infection. Although the success behind the studies that used this approach has been attributed to the potency and neutralization breadth of anti-HIV-1 antibodies, several lines of evidence support the idea that specific antibody-dependent effector functions, particularly antibody-dependent cellular cytotoxicity (ADCC), play a critical role in controlling HIV-1 infection. In this review, we showed that there is a direct association between the activation of ADCC and better clinical outcomes. This, in turn, suggests that ADCC could be harnessed to control HIV-1 infection. To this end, we addressed the passive administration of bNAbs capable of selectively activating ADCC responses to HIV-1 patients. Finally, we summarized the potential barriers that may impede the optimal activation of ADCC during HIV-1 infection and provided strategic solutions to overcome these barriers." @default.
- W2905256920 created "2018-12-22" @default.
- W2905256920 creator A5028416206 @default.
- W2905256920 creator A5051404911 @default.
- W2905256920 creator A5073070891 @default.
- W2905256920 date "2018-12-07" @default.
- W2905256920 modified "2023-10-16" @default.
- W2905256920 title "Harnessing Antibody-Dependent Cellular Cytotoxicity To Control HIV-1 Infection" @default.
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