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• W2905291282 endingPage "H445" @default.
• W2905291282 startingPage "H435" @default.
• W2905291282 abstract "Among the different cardiovascular disease complications, atherosclerosis-induced myocardial infarction (MI) is the major contributor of heart failure (HF) and loss of life. This review presents short- and long-term features of post-MI in human hearts and animal models. It is known that the heart does not regenerate, and thus loss of cardiac cells after an MI event is permanent. In survivors of a heart attack, multiple neurohumoral adjustments as well as simultaneous remodeling in both infarcted and noninfarcted regions of the heart help sustain pump function post-MI. In the early phase, migration of inflammatory cells to the infarcted area helps repair and remove the cell debris, while apoptosis results in the elimination of damaged cardiomyocytes, and there is an increase in the antioxidant response to protect the survived myocardium against oxidative stress (OS) injury. However, in the late phase, it appears that there is a relative increase in OS and activation of the innate inflammatory response in cardiomyocytes without any obvious inflammatory cells. In this late stage in survivors of MI, a progressive slow activation of these processes leads to apoptosis, fibrosis, cardiac dysfunction, and HF. Thus, this second phase of an increase in OS, innate inflammatory response, and apoptosis results in wall thinning, dilatation, and consequently HF. It is important to note that this inflammatory response appears to be innate to cardiomyocytes. Blunting of this innate immune cardiomyocyte response may offer new hope for the management of HF." @default.
• W2905291282 created "2018-12-22" @default.
• W2905291282 creator A5010073861 @default.
• W2905291282 creator A5023193135 @default.
• W2905291282 creator A5039811091 @default.
• W2905291282 creator A5048278410 @default.
• W2905291282 creator A5084669174 @default.
• W2905291282 date "2019-03-01" @default.
• W2905291282 modified "2023-10-09" @default.
• W2905291282 title "Innate immune response in the pathogenesis of heart failure in survivors of myocardial infarction" @default.
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