Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905297923> ?p ?o ?g. }
- W2905297923 abstract "Pancreatic cancer is a malignancy with an extremely poor prognosis. Chronic pancreatitis is a well-known risk factor for pancreatic cancer. Inflammation is thought to influence carcinogenesis through DNA damage and activation of intracellular signaling pathways. Many transcription factors and signaling pathways co-operate to determine and maintain cell identity at each phase of pancreatic organogenesis and cell differentiation. Recent studies have shown that carcinogenesis is promoted through the suppression of transcription factors related to differentiation. Pancreatitis also demonstrates transcriptional changes, suggesting that multifactorial epigenetic changes lead to impaired differentiation. Taken together, these factors may constitute an important framework for pancreatic carcinogenesis. In this review, we discuss the role of inflammation and de-differentiation in the development of pancreatic cancer, as well as the future of novel therapeutic applications." @default.
- W2905297923 created "2018-12-22" @default.
- W2905297923 creator A5008385611 @default.
- W2905297923 creator A5028047142 @default.
- W2905297923 creator A5046522736 @default.
- W2905297923 creator A5059311581 @default.
- W2905297923 creator A5081648528 @default.
- W2905297923 creator A5084040015 @default.
- W2905297923 creator A5087946326 @default.
- W2905297923 creator A5088533861 @default.
- W2905297923 creator A5088794158 @default.
- W2905297923 date "2018-12-06" @default.
- W2905297923 modified "2023-10-01" @default.
- W2905297923 title "Inflammation and de-differentiation in pancreatic carcinogenesis" @default.
- W2905297923 cites W1480887469 @default.
- W2905297923 cites W1638654994 @default.
- W2905297923 cites W1782967980 @default.
- W2905297923 cites W1964989598 @default.
- W2905297923 cites W1965887568 @default.
- W2905297923 cites W1973725287 @default.
- W2905297923 cites W1977379410 @default.
- W2905297923 cites W1980447806 @default.
- W2905297923 cites W1983959103 @default.
- W2905297923 cites W1990826732 @default.
- W2905297923 cites W1990893332 @default.
- W2905297923 cites W1997718215 @default.
- W2905297923 cites W1999071717 @default.
- W2905297923 cites W1999182967 @default.
- W2905297923 cites W2010171965 @default.
- W2905297923 cites W2011710385 @default.
- W2905297923 cites W2019384565 @default.
- W2905297923 cites W2019517037 @default.
- W2905297923 cites W2021766591 @default.
- W2905297923 cites W2025015384 @default.
- W2905297923 cites W2039916144 @default.
- W2905297923 cites W2044045006 @default.
- W2905297923 cites W2051279880 @default.
- W2905297923 cites W2054064942 @default.
- W2905297923 cites W2056646351 @default.
- W2905297923 cites W2059221926 @default.
- W2905297923 cites W2063382154 @default.
- W2905297923 cites W2066135299 @default.
- W2905297923 cites W2078012552 @default.
- W2905297923 cites W2081681778 @default.
- W2905297923 cites W2084239507 @default.
- W2905297923 cites W2084277057 @default.
- W2905297923 cites W2088693506 @default.
- W2905297923 cites W2089688272 @default.
- W2905297923 cites W2096942972 @default.
- W2905297923 cites W2105322112 @default.
- W2905297923 cites W2107890914 @default.
- W2905297923 cites W2108100098 @default.
- W2905297923 cites W2113939834 @default.
- W2905297923 cites W2116100337 @default.
- W2905297923 cites W2116554142 @default.
- W2905297923 cites W2121139915 @default.
- W2905297923 cites W2123852594 @default.
- W2905297923 cites W2124088238 @default.
- W2905297923 cites W2126268972 @default.
- W2905297923 cites W2127689078 @default.
- W2905297923 cites W2129740176 @default.
- W2905297923 cites W2132387165 @default.
- W2905297923 cites W2137987484 @default.
- W2905297923 cites W2143192323 @default.
- W2905297923 cites W2152181022 @default.
- W2905297923 cites W2153042210 @default.
- W2905297923 cites W2155869778 @default.
- W2905297923 cites W2156950220 @default.
- W2905297923 cites W2157733612 @default.
- W2905297923 cites W2160348277 @default.
- W2905297923 cites W2166994863 @default.
- W2905297923 cites W2169837598 @default.
- W2905297923 cites W2171023809 @default.
- W2905297923 cites W2285093314 @default.
- W2905297923 cites W2316005448 @default.
- W2905297923 cites W2463141307 @default.
- W2905297923 cites W2467828327 @default.
- W2905297923 cites W2512572928 @default.
- W2905297923 cites W2554987853 @default.
- W2905297923 cites W2593410994 @default.
- W2905297923 cites W2608757343 @default.
- W2905297923 cites W2614218457 @default.
- W2905297923 cites W2750333573 @default.
- W2905297923 cites W2772764150 @default.
- W2905297923 cites W2773026993 @default.
- W2905297923 cites W2785829537 @default.
- W2905297923 cites W2800062702 @default.
- W2905297923 cites W2803200695 @default.
- W2905297923 cites W2884996434 @default.
- W2905297923 cites W2887805383 @default.
- W2905297923 cites W2888610169 @default.
- W2905297923 cites W2917837889 @default.
- W2905297923 cites W4229719081 @default.
- W2905297923 cites W4290727473 @default.
- W2905297923 doi "https://doi.org/10.12998/wjcc.v6.i15.882" @default.
- W2905297923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6288496" @default.
- W2905297923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30568942" @default.
- W2905297923 hasPublicationYear "2018" @default.
- W2905297923 type Work @default.
- W2905297923 sameAs 2905297923 @default.