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• W2905312073 abstract "Abstract Background Ulcerative colitis (UC) is a kind of complex immune disease, the pathogenesis of which remains elusive. Destruction of the intestinal barrier, extreme inflammation, oxidative stress, and apoptosis might play key roles in the development of UC. In previous studies, we observed that Qingchang Wenzhong granule (QCWZG) had the exact effect on the remission of UC in the clinic; however, the underlying mechanism has not been identified. This study aimed to reveal the effects of QCWZG on the intestinal physical barrier and the interactive network of inflammation, oxidative stress, and apoptosis in rats with dextran sulfate sodium (DSS)–induced colitis. Methods Sixty rats were randomly divided into six groups: blank group, model group, high/mild/low‐dose QCWZG groups, and mesalazine group. The rats in the experimental group drank 4% DSS for 7 days and 1% DSS for the subsequent 7 days. Different medications or distilled water was supplied by intragastric administration for 7 days. The levels of colitis and indices related to inflammation, oxidative stress, and apoptosis were assessed. Results Compared with the model group, the QCWZG group ( P < 0.05) demonstrated attenuated disease activity index, colonic mucosa disease index, histological lesions, and colonic weights; lower levels of inflammatory substances, such as interleukin (IL)‐1α, IL‐6, tumor necrosis factor‐α, and myeloperoxidase; lower levels of malondialdehyde; and increased levels of superoxide dismutase and glutathione peroxidase. The QCWZG group also demonstrated elevated expression of Bcl‐2 and occluding but downregulated db expression of Bax and caspase 3 in the colon. Conclusion QCWZG could relieve rats with DSS‐induced colitis from UC symptoms by improving the intestinal physical barrier, which resists the interactive network of inflammation, oxidative stress, apoptosis, and their overactivated interactions." @default.
• W2905312073 created "2018-12-22" @default.
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• W2905312073 date "2018-12-11" @default.
• W2905312073 modified "2023-10-16" @default.
• W2905312073 title "The inhibitory effects of Qingchang Wenzhong granule on the interactive network of inflammation, oxidative stress, and apoptosis in rats with dextran sulfate sodium‐induced colitis" @default.
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• W2905312073 doi "https://doi.org/10.1002/jcb.28280" @default.
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