FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905343669> ?p ?o ?g. }

• W2905343669 endingPage "121" @default.
• W2905343669 startingPage "100" @default.
• W2905343669 abstract "The interpretation and significance of DNA adduct data, their causal relationship to mutations, and their role in risk assessment have been debated for many years. An extended effort to identify key questions and collect relevant data to address them was focused on the ubiquitous low MW N7-alkyl/hydroxyalkylguanine adducts. Several academic, governmental, and industrial laboratories collaborated to gather new data aimed at better understanding the role and potential impact of these adducts in quantifiable genotoxic events (gene mutations/micronucleus). This review summarizes and evaluates the status of dose-response data for DNA adducts and mutations from recent experimental work with standard mutagenic agents and ethylene oxide and propylene oxide, and the importance for risk assessment. This body of evidence demonstrates that small N7-alkyl/hydroxyalkylguanine adducts are not pro-mutagenic and, therefore, adduct formation alone is not adequate evidence to support a mutagenic mode of action. Quantitative methods for dose-response analysis and derivation of thresholds, benchmark dose (BMD), or other points-of-departure (POD) for genotoxic events are now available. Integration of such analyses of genetox data is necessary to properly assess any role for DNA adducts in risk assessment. Regulatory acceptance and application of these insights remain key challenges that only the regulatory community can address by applying the many learnings from recent research. The necessary tools, such as BMDs and PODs, and the example datasets, are now available and sufficiently mature for use by the regulatory community. Environ. Mol. Mutagen. 60: 100-121, 2019. © 2018 The Authors. Environmental and Molecular Mutagenesis published by Wiley Periodicals, Inc. on behalf of Environmental Mutagen Society." @default.
• W2905343669 created "2018-12-22" @default.
• W2905343669 creator A5020495575 @default.
• W2905343669 creator A5026876414 @default.
• W2905343669 creator A5050152542 @default.
• W2905343669 creator A5051491025 @default.
• W2905343669 creator A5058052872 @default.
• W2905343669 creator A5063314670 @default.
• W2905343669 creator A5073569847 @default.
• W2905343669 date "2018-12-10" @default.
• W2905343669 modified "2023-10-17" @default.
• W2905343669 title "Understanding the importance of low‐molecular weight (ethylene oxide‐ and propylene oxide‐induced) DNA adducts and mutations in risk assessment: Insights from 15 years of research and collaborative discussions" @default.
• W2905343669 cites W1480907902 @default.
• W2905343669 cites W1565715668 @default.
• W2905343669 cites W1602417853 @default.
• W2905343669 cites W1940884554 @default.
• W2905343669 cites W1960101167 @default.
• W2905343669 cites W1963682115 @default.
• W2905343669 cites W1965169790 @default.
• W2905343669 cites W1965222994 @default.
• W2905343669 cites W1966729950 @default.
• W2905343669 cites W1969463358 @default.
• W2905343669 cites W1970502777 @default.
• W2905343669 cites W1971344938 @default.
• W2905343669 cites W1972118534 @default.
• W2905343669 cites W1975221427 @default.
• W2905343669 cites W1975485903 @default.
• W2905343669 cites W1975723497 @default.
• W2905343669 cites W1977868806 @default.
• W2905343669 cites W1980296560 @default.
• W2905343669 cites W1981127780 @default.
• W2905343669 cites W1986513448 @default.
• W2905343669 cites W1987021965 @default.
• W2905343669 cites W1987580232 @default.
• W2905343669 cites W1988236914 @default.
• W2905343669 cites W1989469887 @default.
• W2905343669 cites W1993743046 @default.
• W2905343669 cites W1994669907 @default.
• W2905343669 cites W1996369211 @default.
• W2905343669 cites W1997532736 @default.
• W2905343669 cites W1999992375 @default.
• W2905343669 cites W2002736029 @default.
• W2905343669 cites W2002773540 @default.
• W2905343669 cites W2003097148 @default.
• W2905343669 cites W2003559528 @default.
• W2905343669 cites W2003718947 @default.
• W2905343669 cites W2003759956 @default.
• W2905343669 cites W2003929137 @default.
• W2905343669 cites W2006615329 @default.
• W2905343669 cites W2007896777 @default.
• W2905343669 cites W2009978274 @default.
• W2905343669 cites W2012911939 @default.
• W2905343669 cites W2014750558 @default.
• W2905343669 cites W2016589388 @default.
• W2905343669 cites W2016657306 @default.
• W2905343669 cites W2018655433 @default.
• W2905343669 cites W2021322566 @default.
• W2905343669 cites W2021521537 @default.
• W2905343669 cites W2022736748 @default.
• W2905343669 cites W2022770260 @default.
• W2905343669 cites W2028438444 @default.
• W2905343669 cites W2029229226 @default.
• W2905343669 cites W2030132169 @default.
• W2905343669 cites W2032345984 @default.
• W2905343669 cites W2033278279 @default.
• W2905343669 cites W2035382750 @default.
• W2905343669 cites W2045651871 @default.
• W2905343669 cites W2047724233 @default.
• W2905343669 cites W2048739075 @default.
• W2905343669 cites W2050490901 @default.
• W2905343669 cites W2053778111 @default.
• W2905343669 cites W2054848935 @default.
• W2905343669 cites W2057182879 @default.
• W2905343669 cites W2057749204 @default.
• W2905343669 cites W2058436298 @default.
• W2905343669 cites W2058714590 @default.
• W2905343669 cites W2058767968 @default.
• W2905343669 cites W2058877157 @default.
• W2905343669 cites W2059852484 @default.
• W2905343669 cites W2062742701 @default.
• W2905343669 cites W2062971878 @default.
• W2905343669 cites W2063070387 @default.
• W2905343669 cites W2063222926 @default.
• W2905343669 cites W2065285722 @default.
• W2905343669 cites W2066199073 @default.
• W2905343669 cites W2067561557 @default.
• W2905343669 cites W2074498032 @default.
• W2905343669 cites W2074554305 @default.
• W2905343669 cites W2075365683 @default.
• W2905343669 cites W2075499212 @default.
• W2905343669 cites W2077407509 @default.
• W2905343669 cites W2079047184 @default.
• W2905343669 cites W2087295465 @default.
• W2905343669 cites W2092515517 @default.
• W2905343669 cites W2095590111 @default.
• W2905343669 cites W2097997319 @default.
• W2905343669 cites W2102357766 @default.
• W2905343669 cites W2103622212 @default.

• next