FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905383846> ?p ?o ?g. }

• W2905383846 endingPage "755" @default.
• W2905383846 startingPage "746" @default.
• W2905383846 abstract "Neoadjuvant radiation is recommended for locally advanced rectal cancer, with proven benefit in local control but not in disease-free survival. However, the impact of long-course radiation on postoperative bowel function and quality of life (QOL) remains controversial. This study aimed to investigate the impact of long-course neoadjuvant radiation on bowel function and QOL, and to identify risk factors for severe bowel dysfunction. Patients who underwent long-course neoadjuvant chemoradiotherapy (nCRT) or chemotherapy (nCT) followed by radical low anterior resection for locally advanced rectal cancer were recruited from the FOWARC randomized controlled trial. Low anterior resection syndrome (LARS) score and European Organisation for Research and Treatment of Cancer (EORTC) C30/CR29 questionnaires were used to assess bowel function and QOL, respectively. Overall, 220 patients responded after a median follow-up of 40.2 months, of whom 119 (54.1%) reported major LARS, 74 (33.6%) reported minor LARS, and 27 (12.3%) reported no LARS. Compared with the nCT group, the nCRT group reported more major LARS (64.4% vs. 38.6%, p < 0.001) and worse QOL. Long-course neoadjuvant radiation (OR 2.20, 95% CI 1.24–3.91; p = 0.007), height of anastomosis (OR 0.74, 95% CI 0.63–0.88; p < 0.001), and diverting ileostomy (OR 2.59, 95% CI 1.27–5.30; p = 0.009) were independent risk factors for major LARS. Long-course neoadjuvant radiation, along with low anastomosis, are likely independent risk factors for postoperative bowel function and QOL. Our findings might have implications for alleviating LARS and improving QOL by informing selection of neoadjuvant treatment." @default.
• W2905383846 created "2018-12-22" @default.
• W2905383846 creator A5001240684 @default.
• W2905383846 creator A5008548693 @default.
• W2905383846 creator A5012853410 @default.
• W2905383846 creator A5014215331 @default.
• W2905383846 creator A5024807610 @default.
• W2905383846 creator A5026194818 @default.
• W2905383846 creator A5050773664 @default.
• W2905383846 creator A5062701102 @default.
• W2905383846 creator A5073216396 @default.
• W2905383846 creator A5088141052 @default.
• W2905383846 creator A5089642545 @default.
• W2905383846 date "2018-12-07" @default.
• W2905383846 modified "2023-10-15" @default.
• W2905383846 title "Impact of Long-Course Neoadjuvant Radiation on Postoperative Low Anterior Resection Syndrome and Quality of Life in Rectal Cancer: Post Hoc Analysis of a Randomized Controlled Trial" @default.
• W2905383846 cites W1587782074 @default.
• W2905383846 cites W1944391634 @default.
• W2905383846 cites W1947168884 @default.
• W2905383846 cites W1975172590 @default.
• W2905383846 cites W1988071238 @default.
• W2905383846 cites W1989342190 @default.
• W2905383846 cites W2014869963 @default.
• W2905383846 cites W2019004989 @default.
• W2905383846 cites W2019275335 @default.
• W2905383846 cites W2026172966 @default.
• W2905383846 cites W2028246254 @default.
• W2905383846 cites W2036776638 @default.
• W2905383846 cites W2043407642 @default.
• W2905383846 cites W2043447853 @default.
• W2905383846 cites W2062201085 @default.
• W2905383846 cites W2077188080 @default.
• W2905383846 cites W2080300726 @default.
• W2905383846 cites W2084689669 @default.
• W2905383846 cites W2095090106 @default.
• W2905383846 cites W2095439981 @default.
• W2905383846 cites W2101491513 @default.
• W2905383846 cites W2106014206 @default.
• W2905383846 cites W2116127833 @default.
• W2905383846 cites W2125452425 @default.
• W2905383846 cites W2138728054 @default.
• W2905383846 cites W2140158308 @default.
• W2905383846 cites W2159691094 @default.
• W2905383846 cites W2167571044 @default.
• W2905383846 cites W2171071416 @default.
• W2905383846 cites W2333027942 @default.
• W2905383846 cites W2343980766 @default.
• W2905383846 cites W2480199919 @default.
• W2905383846 cites W2492618519 @default.
• W2905383846 cites W2582069969 @default.
• W2905383846 cites W2627012193 @default.
• W2905383846 cites W2731352076 @default.
• W2905383846 cites W4239081737 @default.
• W2905383846 doi "https://doi.org/10.1245/s10434-018-07096-8" @default.
• W2905383846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30536129" @default.
• W2905383846 hasPublicationYear "2018" @default.
• W2905383846 type Work @default.
• W2905383846 sameAs 2905383846 @default.
• W2905383846 citedByCount "71" @default.
• W2905383846 countsByYear W29053838462019 @default.
• W2905383846 countsByYear W29053838462020 @default.
• W2905383846 countsByYear W29053838462021 @default.
• W2905383846 countsByYear W29053838462022 @default.
• W2905383846 countsByYear W29053838462023 @default.
• W2905383846 crossrefType "journal-article" @default.
• W2905383846 hasAuthorship W2905383846A5001240684 @default.
• W2905383846 hasAuthorship W2905383846A5008548693 @default.
• W2905383846 hasAuthorship W2905383846A5012853410 @default.
• W2905383846 hasAuthorship W2905383846A5014215331 @default.
• W2905383846 hasAuthorship W2905383846A5024807610 @default.
• W2905383846 hasAuthorship W2905383846A5026194818 @default.
• W2905383846 hasAuthorship W2905383846A5050773664 @default.
• W2905383846 hasAuthorship W2905383846A5062701102 @default.
• W2905383846 hasAuthorship W2905383846A5073216396 @default.
• W2905383846 hasAuthorship W2905383846A5088141052 @default.
• W2905383846 hasAuthorship W2905383846A5089642545 @default.
• W2905383846 hasBestOaLocation W29053838461 @default.
• W2905383846 hasConcept C121608353 @default.
• W2905383846 hasConcept C126322002 @default.
• W2905383846 hasConcept C141071460 @default.
• W2905383846 hasConcept C159110408 @default.
• W2905383846 hasConcept C168563851 @default.
• W2905383846 hasConcept C2778292576 @default.
• W2905383846 hasConcept C2778424827 @default.
• W2905383846 hasConcept C2779951463 @default.
• W2905383846 hasConcept C2780140570 @default.
• W2905383846 hasConcept C509974204 @default.
• W2905383846 hasConcept C526805850 @default.
• W2905383846 hasConcept C530470458 @default.
• W2905383846 hasConcept C71924100 @default.
• W2905383846 hasConceptScore W2905383846C121608353 @default.
• W2905383846 hasConceptScore W2905383846C126322002 @default.
• W2905383846 hasConceptScore W2905383846C141071460 @default.
• W2905383846 hasConceptScore W2905383846C159110408 @default.
• W2905383846 hasConceptScore W2905383846C168563851 @default.
• W2905383846 hasConceptScore W2905383846C2778292576 @default.
• W2905383846 hasConceptScore W2905383846C2778424827 @default.
• W2905383846 hasConceptScore W2905383846C2779951463 @default.

• next