FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905437176> ?p ?o ?g. }

• W2905437176 endingPage "44367" @default.
• W2905437176 startingPage "44354" @default.
• W2905437176 abstract "Microfluidics technology is emerging as a promising strategy in improving the oral delivery of proteins and peptides. Herein, a multistage drug delivery system is proposed as a step forward in the development of noninvasive therapies. Undecylenic acid-modified thermally hydrocarbonized porous silicon (UnPSi) nanoparticles (NPs) were functionalized with the Fc fragment of immunoglobulin G for targeting purposes. Glucagon-like peptide-1 (GLP-1) was loaded into the NPs as a model antidiabetic drug. Fc-UnPSi NPs were coated with mucoadhesive chitosan and ultimately entrapped into a polymeric matrix with pH-responsive properties by microfluidic nanoprecipitation. The final formulation showed a controlled and narrow size distribution. The pH-responsive matrix remained intact in acidic conditions, dissolving only in intestinal pH, resulting in a sustained release of the payload. The NPs presented high cytocompatibility and increased levels of interaction with intestinal cells when functionalized with the Fc fragment, which was supported by the validation of the Fc-fragment integrity after conjugation to the NPs. Finally, the Fc-conjugated NPs showed augmented GLP-1 permeability in an intestinal in vitro model. These results highlight the potential of microfluidics as an advanced technique for the preparation of multistage platforms for oral administration. Moreover, this study provides new insights on the potential of the Fc receptor transcytotic capacity for the development of targeted therapies." @default.
• W2905437176 created "2018-12-22" @default.
• W2905437176 creator A5002156892 @default.
• W2905437176 creator A5004912857 @default.
• W2905437176 creator A5024426748 @default.
• W2905437176 creator A5025104298 @default.
• W2905437176 creator A5035901179 @default.
• W2905437176 creator A5041458969 @default.
• W2905437176 creator A5052205388 @default.
• W2905437176 creator A5054957157 @default.
• W2905437176 creator A5070401823 @default.
• W2905437176 creator A5071356523 @default.
• W2905437176 creator A5072925575 @default.
• W2905437176 creator A5075882111 @default.
• W2905437176 creator A5084426844 @default.
• W2905437176 date "2018-12-07" @default.
• W2905437176 modified "2023-10-14" @default.
• W2905437176 title "Microfluidic Nanoassembly of Bioengineered Chitosan-Modified FcRn-Targeted Porous Silicon Nanoparticles @ Hypromellose Acetate Succinate for Oral Delivery of Antidiabetic Peptides" @default.
• W2905437176 cites W1630018437 @default.
• W2905437176 cites W1965884363 @default.
• W2905437176 cites W1970424480 @default.
• W2905437176 cites W1970956141 @default.
• W2905437176 cites W1971938094 @default.
• W2905437176 cites W1974737102 @default.
• W2905437176 cites W1984335567 @default.
• W2905437176 cites W1996246992 @default.
• W2905437176 cites W1998624966 @default.
• W2905437176 cites W2003276331 @default.
• W2905437176 cites W2003741425 @default.
• W2905437176 cites W2013630538 @default.
• W2905437176 cites W2016602599 @default.
• W2905437176 cites W2020451302 @default.
• W2905437176 cites W2021693796 @default.
• W2905437176 cites W2022234371 @default.
• W2905437176 cites W2039018178 @default.
• W2905437176 cites W2041517295 @default.
• W2905437176 cites W2041852539 @default.
• W2905437176 cites W2044265633 @default.
• W2905437176 cites W2046420363 @default.
• W2905437176 cites W2060268772 @default.
• W2905437176 cites W2060544357 @default.
• W2905437176 cites W2068835038 @default.
• W2905437176 cites W2075689961 @default.
• W2905437176 cites W2077372959 @default.
• W2905437176 cites W2078593198 @default.
• W2905437176 cites W2079261830 @default.
• W2905437176 cites W2080181678 @default.
• W2905437176 cites W2081676858 @default.
• W2905437176 cites W2086187432 @default.
• W2905437176 cites W2087240044 @default.
• W2905437176 cites W2091369121 @default.
• W2905437176 cites W2105865453 @default.
• W2905437176 cites W2112686652 @default.
• W2905437176 cites W2113413385 @default.
• W2905437176 cites W2128127404 @default.
• W2905437176 cites W2128958387 @default.
• W2905437176 cites W2129666943 @default.
• W2905437176 cites W2136916366 @default.
• W2905437176 cites W2145756312 @default.
• W2905437176 cites W2154555351 @default.
• W2905437176 cites W2157877216 @default.
• W2905437176 cites W2167279371 @default.
• W2905437176 cites W2226848016 @default.
• W2905437176 cites W2307281814 @default.
• W2905437176 cites W2520108054 @default.
• W2905437176 cites W2564012089 @default.
• W2905437176 cites W2619669967 @default.
• W2905437176 cites W2622584765 @default.
• W2905437176 cites W2784085811 @default.
• W2905437176 cites W2789728104 @default.
• W2905437176 cites W2807260064 @default.
• W2905437176 cites W939982907 @default.
• W2905437176 doi "https://doi.org/10.1021/acsami.8b20821" @default.
• W2905437176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30525379" @default.
• W2905437176 hasPublicationYear "2018" @default.
• W2905437176 type Work @default.
• W2905437176 sameAs 2905437176 @default.
• W2905437176 citedByCount "43" @default.
• W2905437176 countsByYear W29054371762019 @default.
• W2905437176 countsByYear W29054371762020 @default.
• W2905437176 countsByYear W29054371762021 @default.
• W2905437176 countsByYear W29054371762022 @default.
• W2905437176 countsByYear W29054371762023 @default.
• W2905437176 crossrefType "journal-article" @default.
• W2905437176 hasAuthorship W2905437176A5002156892 @default.
• W2905437176 hasAuthorship W2905437176A5004912857 @default.
• W2905437176 hasAuthorship W2905437176A5024426748 @default.
• W2905437176 hasAuthorship W2905437176A5025104298 @default.
• W2905437176 hasAuthorship W2905437176A5035901179 @default.
• W2905437176 hasAuthorship W2905437176A5041458969 @default.
• W2905437176 hasAuthorship W2905437176A5052205388 @default.
• W2905437176 hasAuthorship W2905437176A5054957157 @default.
• W2905437176 hasAuthorship W2905437176A5070401823 @default.
• W2905437176 hasAuthorship W2905437176A5071356523 @default.
• W2905437176 hasAuthorship W2905437176A5072925575 @default.
• W2905437176 hasAuthorship W2905437176A5075882111 @default.
• W2905437176 hasAuthorship W2905437176A5084426844 @default.
• W2905437176 hasConcept C155672457 @default.

• next