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- W2905490272 endingPage "716" @default.
- W2905490272 startingPage "703" @default.
- W2905490272 abstract "Pulmonary arterial hypertension (PAH) is a severe condition characterised by remodelling of precapillary pulmonary arteries sometimes associated with mutations in the bone morphogenetic protein receptor type 2 (BMPR2) gene. Even in the absence of BMPR2 mutations, increased transforming growth factor (TGF)β receptor signalling and decreased BMPRII signalling have been shown to contribute to PAH pathogenesis. In this Keynote, we review the potential mechanisms by which the imbalance of BMP/TGFβ signalling contributes to endothelial dysfunction, vascular remodelling, inflammation and disordered angiogenesis in PAH. Additionally, we highlight how currently used drugs can influence BMP/TGFβ signalling. Finally, we browse the newly developed therapeutic approaches targeting BMPRII and TGFβ signalling pathways by focusing on preclinical studies and clinical trials and put them into perspectives." @default.
- W2905490272 created "2018-12-22" @default.
- W2905490272 creator A5037443668 @default.
- W2905490272 creator A5042615714 @default.
- W2905490272 creator A5058591852 @default.
- W2905490272 creator A5066741453 @default.
- W2905490272 date "2019-03-01" @default.
- W2905490272 modified "2023-10-14" @default.
- W2905490272 title "TGFβ and BMPRII signalling pathways in the pathogenesis of pulmonary arterial hypertension" @default.
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