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- W2905518333 abstract "It is crucial to overcome the skull-based contrast loss of cerebral structures in the development of high-resolution X-ray phase-contrast transcranial brain imaging. The present study aimed to determine the consequence of microporous skull-based scattering and its correlation with the contrast loss in a dark-field imaging-computed tomography transcranial brain imaging setup and to suggest methods for visualizing interior structures in analyzer-based X-ray transcranial brain CT imaging. Virtual-skull brain phantoms that mimic the microporous structure of the skull and internal structures including gray/white matter, glioma edema, and the central necrosis of glioma were prepared for wave-propagation simulation of dark-field computed tomography imaging. Reconstruction of refraction angle images and sinogram analysis of angle deviation showed microporous skull-mediated increases in the right-left angle mismatch and out-of-range values in curve fitting with a rocking curve, which was correlated with the contrast loss for internal structures. Correcting the angle mismatch and artificially widening the rocking curve both restored contrast to the internal structures in the reconstructed images. In conclusion, the contrast loss in analyzer-based X-ray diffraction for transcranial brain imaging was related to increases in microporous skull-mediated angle mismatches and out-of-range values when calculating refraction angles using the analyzer rocking curve. This contrast loss may be resolved by using refraction angle measurements from an analyzer crystal with a wider rocking curve or by using an algorithm such as a neural network that can distinguish the left/right refraction angle for a given intensity in a rocking curve." @default.
- W2905518333 created "2018-12-22" @default.
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- W2905518333 date "2018-12-18" @default.
- W2905518333 modified "2023-09-23" @default.
- W2905518333 title "Wave-propagation simulation and dark-field computed tomography imaging study to elucidate the contrast-loss problem in X-ray diffraction-based transcranial brain imaging" @default.
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- W2905518333 doi "https://doi.org/10.1063/1.5063360" @default.
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