Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905528088> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2905528088 endingPage "36835" @default.
- W2905528088 startingPage "36833" @default.
- W2905528088 abstract "// Natalay Kouprina 1 , Yves Pommier 1 and Vladimir Larionov 1 1 Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA Correspondence to: Natalay Kouprina, email: kouprinn@mail.nih.gov Yves Pommier, email: pommier@nih.gov Vladimir Larionov, email: larionov@mail.nih.gov Keywords: chromosome instability; CIN; human artificial chromosome; HAC; anti-cancer drugs Received: November 07, 2018 Accepted: November 16, 2018 Published: December 07, 2018 ABSTRACT Human artificial chromosomes (HACs) bearing functional kinetochores have been exploited as promising systems for gene delivery and expression and in studies of different epigenetic modifications on kinetochore structure and function. The HAC-based technology has been also used to develop drug screening and assessment strategies to manipulate the CIN (chromosome instability) phenotype in cancer cells. More recently, we designed a new protocol for systematic analysis of compounds specifically targeting telomeres and telomerase. This approach used two isogenic cell lines containing a circular HAC (lacking telomeres) and a linear HAC (containing telomeres): compounds that target telomerase or telomeres should preferentially induce loss of the linear HAC but not the circular HAC. This platform enables identification and ranking of compounds that greatly increase chromosome mis-segregation rates as a result of telomere dysfunction and may expedite the development of new therapeutic strategies for cancer treatment." @default.
- W2905528088 created "2018-12-22" @default.
- W2905528088 creator A5042114293 @default.
- W2905528088 creator A5060435628 @default.
- W2905528088 creator A5084764847 @default.
- W2905528088 date "2018-12-07" @default.
- W2905528088 modified "2023-10-18" @default.
- W2905528088 title "Novel screen for anti-cancer drugs that elevate chromosome instability (CIN) using human artificial chromosome (HAC)" @default.
- W2905528088 cites W1992836740 @default.
- W2905528088 cites W2097867892 @default.
- W2905528088 cites W2100215079 @default.
- W2905528088 cites W2111168474 @default.
- W2905528088 cites W2112784018 @default.
- W2905528088 cites W2131052472 @default.
- W2905528088 cites W2270468128 @default.
- W2905528088 cites W2309072796 @default.
- W2905528088 cites W2885100656 @default.
- W2905528088 cites W2888871749 @default.
- W2905528088 doi "https://doi.org/10.18632/oncotarget.26406" @default.
- W2905528088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6305142" @default.
- W2905528088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30627324" @default.
- W2905528088 hasPublicationYear "2018" @default.
- W2905528088 type Work @default.
- W2905528088 sameAs 2905528088 @default.
- W2905528088 citedByCount "2" @default.
- W2905528088 countsByYear W29055280882020 @default.
- W2905528088 countsByYear W29055280882022 @default.
- W2905528088 crossrefType "journal-article" @default.
- W2905528088 hasAuthorship W2905528088A5042114293 @default.
- W2905528088 hasAuthorship W2905528088A5060435628 @default.
- W2905528088 hasAuthorship W2905528088A5084764847 @default.
- W2905528088 hasBestOaLocation W29055280881 @default.
- W2905528088 hasConcept C104317684 @default.
- W2905528088 hasConcept C121608353 @default.
- W2905528088 hasConcept C125593758 @default.
- W2905528088 hasConcept C140752955 @default.
- W2905528088 hasConcept C153911025 @default.
- W2905528088 hasConcept C177336024 @default.
- W2905528088 hasConcept C30481170 @default.
- W2905528088 hasConcept C41091548 @default.
- W2905528088 hasConcept C502942594 @default.
- W2905528088 hasConcept C54355233 @default.
- W2905528088 hasConcept C70721500 @default.
- W2905528088 hasConcept C86803240 @default.
- W2905528088 hasConcept C94581717 @default.
- W2905528088 hasConcept C96232424 @default.
- W2905528088 hasConceptScore W2905528088C104317684 @default.
- W2905528088 hasConceptScore W2905528088C121608353 @default.
- W2905528088 hasConceptScore W2905528088C125593758 @default.
- W2905528088 hasConceptScore W2905528088C140752955 @default.
- W2905528088 hasConceptScore W2905528088C153911025 @default.
- W2905528088 hasConceptScore W2905528088C177336024 @default.
- W2905528088 hasConceptScore W2905528088C30481170 @default.
- W2905528088 hasConceptScore W2905528088C41091548 @default.
- W2905528088 hasConceptScore W2905528088C502942594 @default.
- W2905528088 hasConceptScore W2905528088C54355233 @default.
- W2905528088 hasConceptScore W2905528088C70721500 @default.
- W2905528088 hasConceptScore W2905528088C86803240 @default.
- W2905528088 hasConceptScore W2905528088C94581717 @default.
- W2905528088 hasConceptScore W2905528088C96232424 @default.
- W2905528088 hasIssue "96" @default.
- W2905528088 hasLocation W29055280881 @default.
- W2905528088 hasLocation W29055280882 @default.
- W2905528088 hasLocation W29055280883 @default.
- W2905528088 hasLocation W29055280884 @default.
- W2905528088 hasOpenAccess W2905528088 @default.
- W2905528088 hasPrimaryLocation W29055280881 @default.
- W2905528088 hasRelatedWork W1514142349 @default.
- W2905528088 hasRelatedWork W2003057078 @default.
- W2905528088 hasRelatedWork W2005146652 @default.
- W2905528088 hasRelatedWork W2055434593 @default.
- W2905528088 hasRelatedWork W2100702324 @default.
- W2905528088 hasRelatedWork W2244718408 @default.
- W2905528088 hasRelatedWork W2373738424 @default.
- W2905528088 hasRelatedWork W2614778886 @default.
- W2905528088 hasRelatedWork W2906719431 @default.
- W2905528088 hasRelatedWork W3122261276 @default.
- W2905528088 hasVolume "9" @default.
- W2905528088 isParatext "false" @default.
- W2905528088 isRetracted "false" @default.
- W2905528088 magId "2905528088" @default.
- W2905528088 workType "article" @default.