FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905606541> ?p ?o ?g. }

• W2905606541 abstract "A wide range of biological activity of natural xanthines stimulated the search of biologically active compounds among their synthetic analogues, which led to the creation of a number of medicines (Nihexynum, Proxyphyllinum, Protheobrominum, etc.), which have been successfully applied till present time. It should be noted that the search of new biologically active compounds among xanthine derivatives does not stop. Previously, we had found that xanthine thioderivatives exhibits antioxidant, diuretic, hypoglycemic, antitumor, antimicrobial, anti-inflammatory, analgesic activity. The aim of the work is to elaborate simple laboratory methods of 7-ethyl-3-methylxanthine derivatives synthesis, unspecified in scientific papers earlier, – the basis for the creation of original antimicrobial and antifungal medicines. Materials and methods of research. The melting point has been determined with the help of an open capillary method with PTP-M device. Elemental analysis has been performed with the help of the instrument Elementar Vario L cube, NMR-spectra have been taken on a spectrometer Bruker SF-400 (operating frequency of 400 MHz, solvent DMSO, internal standard – TMS). Study of antimicrobial and antifungal activity of synthesized compounds has been performed by a two-fold serial dilution method. Standard test strains have been used for the study: Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Candida albicans ATCC 885-653. Dimethylsulfoxide was used as the solvent of the compounds. Results and their discussion. Under short-time heating up of 7-ethyl-3-methyl-8-thioxanthine with methyl chloroacetate in a water-ethanol solution of sodium hydroxide leads to the formation of the corresponding ester. 3-Methyl-7-ethylxanthinyl-8-thioacethydrazide was obtained by hydrazinolysis of methyl(3-methyl-7-ethylxanthinyl-8-)thioacetate. Corresponding 7-ethyl-3-methylxanthinyl-8-thioacetic acid benzylidene hydrazides were obtained by the reaction of hydrazide with aromatic aldehydes. Structure of synthesized compounds was definitely proved by NMR-spectroscopy. Conducting primary screening research of antimicrobial activity of 8-thioderivatives of 7-ethyl-3-methylxanthine, which revealed moderate and weak activity in concentrations 50–100 mcg/ml. 2-Methoxy-5-bromobenzylidenehydrazide showed a pronounced antifungal effect. Conclusions. The preparative method of synthesis of 7-ethyl-3-methylxanthinyl-8-thioacetic acid benzylidene hydrazides, unspecified in scientific papers earlier, was developed. The structure of the synthesized compounds and their existence in the form of a mixture of E- and Z-isomers in the ratio 2:1 was proved with the help of the NMR spectroscopy data. The antimicrobial and antifungal effects of the obtained compounds were studied. Priorities for further research of biologically active compounds have been outlined." @default.
• W2905606541 created "2019-01-01" @default.
• W2905606541 creator A5010252649 @default.
• W2905606541 creator A5013133403 @default.
• W2905606541 creator A5014112687 @default.
• W2905606541 creator A5026491085 @default.
• W2905606541 creator A5063610925 @default.
• W2905606541 date "2018-10-24" @default.
• W2905606541 modified "2023-10-18" @default.
• W2905606541 title "Synthesis, physical-chemical and biological properties of derivatives of 3-methyl-7-ethylxanthinyl-8-thioacetic acid hydrazide" @default.
• W2905606541 cites W1561421265 @default.
• W2905606541 cites W1968871273 @default.
• W2905606541 cites W2481162634 @default.
• W2905606541 cites W2739407160 @default.
• W2905606541 cites W2766850639 @default.
• W2905606541 cites W2807191966 @default.
• W2905606541 cites W2945373673 @default.
• W2905606541 cites W2184738039 @default.
• W2905606541 doi "https://doi.org/10.14739/2409-2932.2018.3.144586" @default.
• W2905606541 hasPublicationYear "2018" @default.
• W2905606541 type Work @default.
• W2905606541 sameAs 2905606541 @default.
• W2905606541 citedByCount "0" @default.
• W2905606541 crossrefType "journal-article" @default.
• W2905606541 hasAuthorship W2905606541A5010252649 @default.
• W2905606541 hasAuthorship W2905606541A5013133403 @default.
• W2905606541 hasAuthorship W2905606541A5014112687 @default.
• W2905606541 hasAuthorship W2905606541A5026491085 @default.
• W2905606541 hasAuthorship W2905606541A5063610925 @default.
• W2905606541 hasBestOaLocation W29056065411 @default.
• W2905606541 hasConcept C116073593 @default.
• W2905606541 hasConcept C13965031 @default.
• W2905606541 hasConcept C178790620 @default.
• W2905606541 hasConcept C185592680 @default.
• W2905606541 hasConcept C202751555 @default.
• W2905606541 hasConcept C21951064 @default.
• W2905606541 hasConcept C2775998212 @default.
• W2905606541 hasConcept C2779858419 @default.
• W2905606541 hasConcept C2780104969 @default.
• W2905606541 hasConcept C2780471494 @default.
• W2905606541 hasConcept C4937899 @default.
• W2905606541 hasConcept C523546767 @default.
• W2905606541 hasConcept C54355233 @default.
• W2905606541 hasConcept C55493867 @default.
• W2905606541 hasConcept C86803240 @default.
• W2905606541 hasConceptScore W2905606541C116073593 @default.
• W2905606541 hasConceptScore W2905606541C13965031 @default.
• W2905606541 hasConceptScore W2905606541C178790620 @default.
• W2905606541 hasConceptScore W2905606541C185592680 @default.
• W2905606541 hasConceptScore W2905606541C202751555 @default.
• W2905606541 hasConceptScore W2905606541C21951064 @default.
• W2905606541 hasConceptScore W2905606541C2775998212 @default.
• W2905606541 hasConceptScore W2905606541C2779858419 @default.
• W2905606541 hasConceptScore W2905606541C2780104969 @default.
• W2905606541 hasConceptScore W2905606541C2780471494 @default.
• W2905606541 hasConceptScore W2905606541C4937899 @default.
• W2905606541 hasConceptScore W2905606541C523546767 @default.
• W2905606541 hasConceptScore W2905606541C54355233 @default.
• W2905606541 hasConceptScore W2905606541C55493867 @default.
• W2905606541 hasConceptScore W2905606541C86803240 @default.
• W2905606541 hasLocation W29056065411 @default.
• W2905606541 hasOpenAccess W2905606541 @default.
• W2905606541 hasPrimaryLocation W29056065411 @default.
• W2905606541 hasRelatedWork W2017866658 @default.
• W2905606541 hasRelatedWork W2022134027 @default.
• W2905606541 hasRelatedWork W2043683447 @default.
• W2905606541 hasRelatedWork W2108968417 @default.
• W2905606541 hasRelatedWork W2150008892 @default.
• W2905606541 hasRelatedWork W2802085199 @default.
• W2905606541 hasRelatedWork W3089130160 @default.
• W2905606541 hasRelatedWork W4289704924 @default.
• W2905606541 hasRelatedWork W2002374332 @default.
• W2905606541 hasRelatedWork W2944496369 @default.
• W2905606541 isParatext "false" @default.
• W2905606541 isRetracted "false" @default.
• W2905606541 magId "2905606541" @default.
• W2905606541 workType "article" @default.