FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905637226> ?p ?o ?g. }

• W2905637226 abstract "Abstract Activating mutations of fibroblast growth factor receptor 3 (FGFR3) are common in urothelial carcinoma of the bladder (UC). Silencing or inhibition of mutant FGFR3 in bladder cancer cell lines is associated with decreased malignant potential, confirming its important driver role in UC. However, understanding of how FGFR3 activation drives urothelial malignant transformation remains limited. We have previously shown that mutant FGFR3 alters the cell-cell and cell-matrix adhesion properties of urothelial cells, resulting in loss of contact-inhibition of proliferation. In this study, we investigate a transcription factor of the ETS-family, ETV5, as a putative effector of FGFR3 signalling in bladder cancer. We show that FGFR3 signalling induces a MAPK/ERK-mediated increase in ETV5 levels, and that this results in increased level of TAZ, a co-transcriptional regulator downstream of the Hippo signalling pathway involved in cell-contact inhibition. We also demonstrate that ETV5 is a key downstream mediator of the oncogenic effects of mutant FGFR3, as its knockdown in FGFR3-mutant bladder cancer cell lines is associated with reduced proliferation and anchorage-independent growth. Overall this study advances our understanding of the molecular alterations occurring during urothelial malignant transformation and indicates TAZ as a possible therapeutic target in FGFR3-dependent bladder tumours." @default.
• W2905637226 created "2019-01-01" @default.
• W2905637226 creator A5000489409 @default.
• W2905637226 creator A5020592939 @default.
• W2905637226 creator A5062994001 @default.
• W2905637226 creator A5064065033 @default.
• W2905637226 date "2019-04-05" @default.
• W2905637226 modified "2023-10-12" @default.
• W2905637226 title "ETV5 links the FGFR3 and Hippo signalling pathways in bladder cancer" @default.
• W2905637226 cites W1563019250 @default.
• W2905637226 cites W1845771548 @default.
• W2905637226 cites W1863585495 @default.
• W2905637226 cites W1972947623 @default.
• W2905637226 cites W1975001408 @default.
• W2905637226 cites W1977038560 @default.
• W2905637226 cites W1978572913 @default.
• W2905637226 cites W1984145333 @default.
• W2905637226 cites W1995082113 @default.
• W2905637226 cites W1996690536 @default.
• W2905637226 cites W2000808630 @default.
• W2905637226 cites W2038683568 @default.
• W2905637226 cites W2049903695 @default.
• W2905637226 cites W2051833845 @default.
• W2905637226 cites W2053073820 @default.
• W2905637226 cites W2053611609 @default.
• W2905637226 cites W2056102163 @default.
• W2905637226 cites W2059871392 @default.
• W2905637226 cites W2062085206 @default.
• W2905637226 cites W2063034913 @default.
• W2905637226 cites W2070378411 @default.
• W2905637226 cites W2070459941 @default.
• W2905637226 cites W2074214732 @default.
• W2905637226 cites W2076154729 @default.
• W2905637226 cites W2077850223 @default.
• W2905637226 cites W2088497968 @default.
• W2905637226 cites W2089415023 @default.
• W2905637226 cites W2089880928 @default.
• W2905637226 cites W2094770831 @default.
• W2905637226 cites W2099709490 @default.
• W2905637226 cites W2110714384 @default.
• W2905637226 cites W2113235293 @default.
• W2905637226 cites W2113727201 @default.
• W2905637226 cites W2122259704 @default.
• W2905637226 cites W2124614719 @default.
• W2905637226 cites W2126375034 @default.
• W2905637226 cites W2129480424 @default.
• W2905637226 cites W2135988274 @default.
• W2905637226 cites W2136054684 @default.
• W2905637226 cites W2136768150 @default.
• W2905637226 cites W2142902504 @default.
• W2905637226 cites W2143895308 @default.
• W2905637226 cites W2144747113 @default.
• W2905637226 cites W2146157729 @default.
• W2905637226 cites W2148682310 @default.
• W2905637226 cites W2166297759 @default.
• W2905637226 cites W2166903499 @default.
• W2905637226 cites W2169501865 @default.
• W2905637226 cites W2170608612 @default.
• W2905637226 cites W2261166893 @default.
• W2905637226 cites W2263837770 @default.
• W2905637226 cites W2291693837 @default.
• W2905637226 cites W2465367340 @default.
• W2905637226 cites W2513343950 @default.
• W2905637226 cites W2515649331 @default.
• W2905637226 cites W2595713273 @default.
• W2905637226 cites W2606683026 @default.
• W2905637226 cites W2763670669 @default.
• W2905637226 doi "https://doi.org/10.1038/s41598-018-36456-3" @default.
• W2905637226 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6450944" @default.
• W2905637226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30952872" @default.
• W2905637226 hasPublicationYear "2019" @default.
• W2905637226 type Work @default.
• W2905637226 sameAs 2905637226 @default.
• W2905637226 citedByCount "14" @default.
• W2905637226 countsByYear W29056372262020 @default.
• W2905637226 countsByYear W29056372262021 @default.
• W2905637226 countsByYear W29056372262022 @default.
• W2905637226 countsByYear W29056372262023 @default.
• W2905637226 crossrefType "journal-article" @default.
• W2905637226 hasAuthorship W2905637226A5000489409 @default.
• W2905637226 hasAuthorship W2905637226A5020592939 @default.
• W2905637226 hasAuthorship W2905637226A5062994001 @default.
• W2905637226 hasAuthorship W2905637226A5064065033 @default.
• W2905637226 hasBestOaLocation W29056372261 @default.
• W2905637226 hasConcept C104317684 @default.
• W2905637226 hasConcept C119056186 @default.
• W2905637226 hasConcept C121608353 @default.
• W2905637226 hasConcept C147708747 @default.
• W2905637226 hasConcept C170493617 @default.
• W2905637226 hasConcept C172512520 @default.
• W2905637226 hasConcept C173396325 @default.
• W2905637226 hasConcept C2780352672 @default.
• W2905637226 hasConcept C2910041100 @default.
• W2905637226 hasConcept C502942594 @default.
• W2905637226 hasConcept C54355233 @default.
• W2905637226 hasConcept C555283112 @default.
• W2905637226 hasConcept C57074206 @default.
• W2905637226 hasConcept C62112901 @default.
• W2905637226 hasConcept C62478195 @default.
• W2905637226 hasConcept C74373430 @default.

• next